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Eterna

@eternagame.org
123 followers 51 following 38 posts

Eterna empowers citizen scientists to help advance medicine through molecular design. Solve puzzles using RNAs, the tiny molecules at the heart of every cell. Website: eternagame.org

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Eterna @eternagame.org · 07/08/2026
Our Replicase pilot results found that the catalytic activity and copyability of the 71-89 polymerase ribozyme can be improved! We have launched a new puzzle for finding a version that excels at both properties simultaneously. Comp methods are encouraged to submit designs!
Puzzle interface displaying the secondary and tertiary structure of the ribozyme.
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Eterna @eternagame.org · 23/07/2026
OpenKnot Round 9 features secondary structures designed by players to create compact, pseudoknotted RNA using 240 bases. GenAI teams also will be testing whether their methods can perform as well as the expert players at a longer length. Check out the puzzle at: eternagame.org/labs/14343053
Screenshot of the Eterna puzzle interface
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Eterna @eternagame.org · 17/07/2026
Eternacon 12 will be Sunday, July 26, 9am to 2pm PT featuring talks on player pseudoknot design techniques, the Montparnasse algorithm solving the Eterna100, an RNA scaffold for cryo-EM, and results for our pilot Replicase puzzle. #RNAsky Free to register at eternagame.org/eternacon/2026
Logo for eternacon 12
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Eterna @eternagame.org · 07/07/2026
Eterna's newest puzzle challenges players to design 240-base RNA strands that will fold into compact pseudoknots. The puzzle provides a metric for counting the number of pairs that cross to form large, synthetic pseudoknots. #RNAsky #citsci Check out the puzzle at eternagame.org/labs/14333719
Screenshot of a complex pseudoknot designed by Eterna player Father Z that demonstrates the puzzle interface.
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Eterna @eternagame.org · 25/05/2026
First AI-generated RNA with novel atomically ordered 3D fold! 🧬 The pseudoknotted secondary structure 'Kissing Multiloops' was designed by an Eterna player then solved by 3 GenAI models as confirmed by cryo-EM. ❄️🔬 #RNASky www.biorxiv.org/content/10.6...
Two dimensional and three dimensional views of three compact RNA molecules designed by generative AI methods.
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Eterna @eternagame.org · 10/03/2026
Town Hall - Saturday, March 14, 9am PT eternagame.org/news/14267278 A University of Delaware researcher will be discussing how he applied #RNA switches Eterna reported in a 2022 PNAS paper to a #CRISPR system for conditional gene activation. #citsci Screenshot of the winning switch design:
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Eterna @eternagame.org · 24/11/2025
A new 3-state Replicase challenge has been launched on Eterna and will only be open for two weeks before sequences are collected for experimental testing at the Das Lab. Will Eterna players be able to improve the catalytic activity of the RNA polymerase? eternagame.org/labs/14183416
The Eterna puzzle interface displaying the three states of the RNA polymerase ribozyme using RibonanzaNet in state 1 and Eternafold in states 2 and 3.
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Eterna @eternagame.org · 29/09/2025
In addition to the RibonanzaNet server hosted by @rdaslab.bsky.social, RNA structure fans can try the new pseudoknotted prediction model in Eterna's RNet Study collection. The 108 puzzles are a mix of experimentally-validated structures and synthetic fabrications. eternagame.org/collections/...
Example eight puzzles in the collection including 8ZMH 1TN1 and PKB 398
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Eterna @eternagame.org · 23/07/2025
Coming up this weekend, Eternacon will feature presentations about fellow #citsci platform @zooniverse.bsky.social and how participants of both Zooniverse and Eterna have created #machinelearning tools for projects. @noirlabastro.bsky.social Register for free at eternagame.org/eternacon/2025
Blue image of ROOL nanocage made of RNA with text on top noting Eternacon dates as July 26 and 27.
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Eterna @eternagame.org · 16/07/2025
Registration for Eterna's annual online conference July 26-27 is open! Come hear from both researchers and players about new approaches to structure-based RNA design and understanding RNA structure. #citsci Full program and free registration at eternagame.org/eternacon/2025
Logo is an RNA nanocage.
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Eterna @eternagame.org · 25/04/2025
National DNA Day celebrates the completion of the human genome project in 2003 and the discovery of the double helix in 1953. The continuing work of dedicated scientists to learn more about the functioning of genes and RNA in the human body is leading to important advances in medicine.
National DNA Day banner
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Eterna @eternagame.org · 24/03/2025
Our 2024 online conference featured two talks on how innovative Eterna players helped RNA structure researchers improve the preparation of RNA sequences for chemical mapping, particularly formatting the padding and barcodes to reduce primer misfolds and smooth read counts. (Link below⬇️)
Screenshot of the conference presentation on barcode composition.
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