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Mario Emilio Ernesto Franco

@ernestofranco.bsky.social
47 followers 129 following 8 posts

🧬🧉⚡ Research Fellow at the University of Bari Aldo Moro

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Reposted by Mario Emilio Ernesto Franco
Team Thomma @teamthomma.bsky.social · 30/10/2025
📣 Now announcing the journal publication 📄 of our work in @newphyt.bsky.social on how Verticillium undermines the plant's 🌱 "cry for help": terrific work by @antonkraege.bsky.social & @wolki95.bsky.social doi.org/10.1111/nph....
doi.org
Undermining the cry for help: the phytopathogenic fungus Verticillium dahliae secretes an antimicrobial effector protein to undermine host recruitment of antagonistic Pseudomonas bacteria
During pathogen attack, plants recruit beneficial microbes in a ‘cry for help’ to mitigate disease development. Simultaneously, pathogens secrete effectors to promote host colonisation through vario...
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Reposted by Mario Emilio Ernesto Franco
Jana U'Ren @you-wren.bsky.social · 20/08/2025
I'm super excited that our photo of Xylaria was selected for the cover of the August issue of #mSystems! journals.asm.org/toc/msystems... This complements our recent article on the secondary metabolism of xylarialean fungi (Franco et al., 2025 vol. 10, e00468-25). @ernestofranco.bsky.social
Zoomed-in photograph of fungus growing on solid media
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Reposted by Mario Emilio Ernesto Franco
Jana U'Ren @you-wren.bsky.social · 09/06/2025
Excited to have our paper out in #mSystems. Pairwise co-cultures of only 7 xylarialean strains yielded >6k unique metabolites vs. 2k from monocultures. High richness reflects an abundance of interaction-specific metabolites. Work led by @ernestofranco.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi | mSystems
Saprotrophic and endophytic xylarialean fungi are among the most prolific producers of bioactive secondary metabolites, with numerous industrial uses as antibiotics, pharmaceuticals, and insecticidal ...
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Mario Emilio Ernesto Franco @ernestofranco.bsky.social · 14/01/2025
Our new preprint is out! A genomic and metagenomic dive into the diversity of microbial carbonic anhydrases. Huge thanks to the amazing team who made this possible! @you-wren.bsky.social @laurameredith.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Genomic and metagenomic survey of microbial carbonic anhydrase genes reveals novel clades, high diversity, and biome-specificity
Carbonic anhydrase (CA) enzymes catalyze the interconversion of carbon dioxide and bicarbonate with an efficiency exceeded only by superoxide dismutase. CA enzymes have convergently evolved multiple t...
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Reposted by Mario Emilio Ernesto Franco
Anna Dewar @annadewar.bsky.social · 08/01/2025
Our review is out in Nature Reviews Genetics! rdcu.be/d5AY2 We show how phylogeny-based methods can resolve the problem of non-independence in genomic datasets. These methods must be considered an essential part of the comparative genomics toolkit. @lauriebelch.bsky.social @stuwest.bsky.social
rdcu.be
A phylogenetic approach to comparative genomics
Nature Reviews Genetics - Controlling for phylogeny is essential in comparative genomics studies, because species, genomes and genes are not independent data points within statistical tests. The...
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Mario Emilio Ernesto Franco @ernestofranco.bsky.social · 07/01/2025
Excited to share our latest preprint! 'Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi'. Deeply grateful to the U'Ren Lab @you-wren.bsky.social and JGI team. tinyurl.com/u32xdpx9
tinyurl.com
Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi
Xylariales is one of the largest and most ecologically diverse fungal orders. Xylarialean fungi are well-known for their chemical diversity, reflecting a hyperdiversity of biosynthetic gene clusters (...
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