iiinova — where your digital self keeps evolving

Reposted by Eric Chow

Ardem Patapoutian @ardemp.bskyverified.social · 09/04/2025

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

cnn.com

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

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Reposted by Eric Chow

Emily Goldberg @dremilygoldberg.bsky.social · 26/03/2025

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵 www.nature.com/articles/s41...

nature.com

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

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Eric Chow @eric-chow.bsky.social · 08/03/2025

Awesome turnout @standupforscience.bsky.social SF today! The Oregon Trail inspired sign was one of my favorite!

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Reposted by Eric Chow

Stand Up for Science! @standupforscience.net · 12/02/2025

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

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Reposted by Eric Chow

Max Kennerly @maxkennerly.bsky.social · 22/02/2025

Just look at these paragraphs from the AP story. Hegseth called Brown unqualified solely because he's Black. Then they fired him... and replaced him with a white guy so indisputably unqualified that he requires a Presidential waiver. This is what "merit" means to them. apnews.com/article/trum...

Hegseth had previously taken aim at Brown. “First of all, you gotta fire, you know, you gotta fire the chairman of Joint Chiefs,” he said flatly in a podcast in November. And in one of his books, he questioned whether Brown got the job because he was Black.

“Was it because of his skin color? Or his skill? We’ll never know, but always doubt — which on its face seems unfair to CQ. But since he has made the race card one of his biggest calling cards, it doesn’t really much matter,” Hegseth wrote.

Caine’s military service includes combat roles in Iraq, special operations postings and positions inside some of the Pentagon’s most classified special access programs. However, it does not include key assignments that were identified in law as prerequisites for the job, with an exemption for the president to waive them if necessary in times of national interest.

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Reposted by Eric Chow

John Streicher @johnstreicher.bsky.social · 08/02/2025

Can I give some unsolicited advice? When communicating on this catastrophe, don’t lead with “I know the NIH is inefficient and needs serious reform, but…”. You are undercutting the entire message and buying into the frame of the arsonists. This is not a scientist audience. No “to be fair” points

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Eric Chow @eric-chow.bsky.social · 08/02/2025

I’m reaching out to my vendors to push them to use their lobbying infrastructure to point out the devastating effects the NIH change will have on the USA’s R&D engine.

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Reposted by Eric Chow

Drug Monkey @drugmonkey.bsky.social · 07/02/2025

all y'all academics who have been naively convinced IDC only goes to useless sub deans are about to find out. they are going to claw the real costs of research out of your unchanged direct costs.

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Reposted by Eric Chow

Jeremy Berg @jeremymberg.bsky.social · 08/02/2025

Indirect rates are not determined by NIH. Instead, they are the product of elaborate negotiations between each institution and the “cognizant federal agency” according to an Office of Management and Budget document, Circular A-21. 1/n

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Eric Chow @eric-chow.bsky.social · 23/12/2024

We just upgraded one of our Illumina NovaSeqX’s to enable the new 25B 100 and 200 cycle kits. New software is supposed to slightly raise PF% and we are seeing that. 10X GEX libraries previously generated 32B reads per flow cell. We seeing over 33B, almost 67B reads in 24 hours for a dual FC run!

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Eric Chow @eric-chow.bsky.social · 18/12/2024

We just got our n6 Tec iconPCR installed. The system monitors NGS library amp with real time functions but each of the 96 wells is independently temperature-controlled and monitored. This is super helpful when you have varying inputs. www.n6tec.com

n6tec.com

Introducing iconPCR

Discover simplicity and innovation combined in our groundbreaking icon PCRTM technology. Stay tuned as we usher in a next paradigm in genomics solutions.

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Eric Chow @eric-chow.bsky.social · 16/12/2024

The new MiSeq i100 should be good to check pooling for the NovaSeqX. Catherine's group is seeing good consistency between the two platforms, but from first glance, it does appear the MiSeq i100 is more consistent with the older iSeq (blue and orange lines).

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Eric Chow @eric-chow.bsky.social · 03/12/2024

The #illumina #NovaSeqX 25B 100 cycle kits should be released sometime this month. These further reduce the cost of applications like single-cell sequencing by ~20%. Besides a cost reduction, the runs will take ~24 vs 48 hours, increasing the throughput of our machines.

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Eric Chow @eric-chow.bsky.social · 28/11/2024

Hello World! I direct the UCSF Center for Advanced Technology (CAT), an on campus genomics center that does a lot of development work in the NGS space. We offer Illumina and PacBio sequencing to groups on and off campus. Other interests in molecular biology and lab automation. cat.ucsf.edu

cat.ucsf.edu

Home

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Reposted by Eric Chow

Armin Töpfer @armintoepfer.com · 14/11/2024

Remember when @pacbio.bsky.social introduced Kinnex and customers suddenly got >40M HiFi transcripts per run? I was tasked to solve scaling up Iso-Seq reference-free clustering and had less than a month. There were a lot of #bioinformatics challenges to be solved More info on isoseq.how or read on🧵

isoseq.how

Iso-Seq Home

Scalable De Novo Isoform Discovery from PacBio HiFi Reads.

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Reposted by Eric Chow

Amy Maxmen, PhD @amymaxmen.bsky.social · 14/11/2024

After many dozens of children died preventable deaths of measles in Samoa, a vaccination campaign was successful. Families hung signs saying "Help!" "I want to live!" RFK Jr fueled the anti-vaxx mvt there & now he's in a much more powerful position here. www.nytimes.com/2019/12/19/w...

nytimes.com

‘Why My Baby?’: How Measles Robbed Samoa of Its Young (Published 2019)

When the virus arrived on its shores, the Pacific island nation was grievously unprepared. It had left the door to contagion wide open, and thousands of children have suffered.

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