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Epithelial Cell Biology in ENT Research Group UCL

@epicentr.bsky.social
697 followers 72 following 11 posts

🔬Stem cell biology and cancer research team at the UCL Institute of Child Health 🥼Led by @robhynds.bsky.social and Colin Butler 📍Great Ormond Street Hospital and University College London www.epicentrlab.org

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Reposted by Epithelial Cell Biology in ENT Research Group UCL
Dr Claire Smith @drclairesmith.bsky.social · 13/07/2026
Huge congratulations to first authors #MachaelaPalor and #TerezaMasonou and to the whole team @uclchildhealth.bsky.social @epicentr.bsky.social and our collaborators. Thank you to families who took part, and to funders #AnimalFreeResearchUK and UKRI/BBSRC
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Reposted by Epithelial Cell Biology in ENT Research Group UCL
British Association for Lung Research @balrcommunity.bsky.social · 25/06/2026
Dr Drew Farr from @epicentr.bsky.social @ucl.ac.uk is talking about how p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells, at #BALR26
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Reposted by Epithelial Cell Biology in ENT Research Group UCL
Rob Hynds @robhynds.bsky.social · 17/06/2026
We've launched a new @epicentr.bsky.social lab website! You'll find information about our research, team, publications, and educational resources on airway epithelial biology and regenerative medicine. www.epicentrlab.org
epicentrlab.org
EpiCENTR Lab | Airway epithelial stem cells, regeneration, cell and gene therapy
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 11/11/2025
Lizzie Maughan @uclchildhealth.bsky.social led this collaboration with Wenhui Song's lab to develop a bespoke airway stent for use in a 5-month-old with near-complete laryngeal stenosis. The novel 3D-printed stent enabled safe airway reconstruction. 📄 doi.org/10.1002/adfm...
doi.org
A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction
A programmable interpenetrating double-network architecture, created via 3D-TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural....
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 16/09/2025
🙏🏻 Thank you to all of our collaborators and funders. We'd love to try this compound out in other primary epithelial cell types, so please get in touch if you have any questions or would like the protocol.
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 16/09/2025
🫁 Human airway basal cells cultured in this medium are also able to engraft and differentiate following transplantation into mouse tracheas suggesting potential for regenerative medicine l
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 16/09/2025
🥼 We generated disease models that recapitulate the disease phenotype for two gene mutations for primary ciliary dyskinesia, including the most commonly mutated gene, DNAH5.
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 16/09/2025
Our latest work is available on BioRxiv! WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity. www.biorxiv.org/content/10.1...
biorxiv.org
WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells
Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...
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Reposted by Epithelial Cell Biology in ENT Research Group UCL
Jess Orr @jess0rr.bsky.social · 24/06/2025
Had a wonderful time at the @bsgct.bsky.social annual conference! I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
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Journal of Cell Science @jcellsci.bsky.social · 17/04/2025
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...
Graphs and micrographs investigating Wnt pathway activating compounds as promoters of airway basal cell proliferation.
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 14/04/2025
Thanks to the UKRMP Engineered Cell Environment Hub and @longfonds.bsky.social BREATH consortia for supporting this work and to the Rosetrees Trust for @jess0rr.bsky.social PhD Plus award.
Immunofluorescence staining of airway organoids cultured in the presence of Wnt activating compounds.
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 14/04/2025
If you are interested in hearing more about our experience in this project and publishing in the Journal of Cell Science, check out Yuki and @jess0rr.bsky.social’s First Person interview doi.org/10.1242/jcs....
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First person – Yuki Ishii and Jessica Orr
ABSTRACT. First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Yu...
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 14/04/2025
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo. doi.org/10.1242/jcs....
doi.org
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 23/12/2024
Happy holidays from everyone in the EpiCENTR group! Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁 (h/t scholargoggler.com)
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Reposted by Epithelial Cell Biology in ENT Research Group UCL
Rob Hynds @robhynds.bsky.social · 17/11/2024
Here's a starter pack that focusses on lung biology, regeneration and cancer. Let me know who I'm missing! go.bsky.app/VC83FZm
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 14/11/2024
Can we join please?
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Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 14/11/2024
Can we join please?
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