Children with chronic liver disease are at increased risk of acute kidney injury (AKI), which could be non-hepatorenal syndrome AKI (non-HRS-AKI) or hepatorenal syndrome AKI (HRS-AKI). Approximately 5...

BackgroundEffective and cost-effective treatments are not always optimally implemented. The benefit forgone due to sub-optimal implementation is often not co...

Objective To develop and validate a machine learning framework for predicting optimal extubation timing in paediatric intensive care units (PICUs), addressing the clinical need for continuous monitori...

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Emergency endotracheal intubation of children is one of the most high-risk procedures in paediatrics. The most common complication is hypoxaemia, with an incidence of up to 50%,1 although haemodynamic...

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By Emma Alexander As a doctor who works in children’s intensive care, I have always been interested in research, especially in research that matters to parents and young children

By Emma Alexander As a doctor who works in children’s intensive care, I have always been interested in research, especially in research that matters to parents and young children

This study provides novel data showing that adverse kidney and blood pressure outcomes remain highly prevalent 10 years after critical illness in childhood. The association with AKI wanes over time.

Background Paediatric acute liver failure (PALF) is a rare condition with high morbidity and mortality. The liver transplant era, and improvements in medical management, have transformed outcomes. How...

Paediatric acute liver failure is a devastating condition with high morbidity and mortality, which is challenging to manage for the hepatologist, inte…