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Ellenberg Lab @ellenberglab.bsky.social · 10/09/2025

Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫. Thanks, Wanlu and all the collaborators!

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Ellenberg Lab @ellenberglab.bsky.social · 21/07/2025

Thanks Aleksander, also for your paper link!

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Reposted by Ellenberg Lab

Anders Sejr Hansen @andersshansen.bsky.social · 20/07/2025

This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C): www.nature.com/articles/s41...

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Ellenberg Lab @ellenberglab.bsky.social · 24/03/2025

Check out Andi's #Bluetorial for a summary of our findings 🙌

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Reposted by Ellenberg Lab

EMBL @embl.org · 24/03/2025

Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪 New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation. @ellenberglab.bsky.social @andibrunner.bsky.social www.embl.org/news/science...

embl.org

How chromosomes shape up for cell division | EMBL

EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped chromosomes

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Ellenberg Lab @ellenberglab.bsky.social · 19/03/2025

We are #hiring! We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes! 1) experimental biologist shorturl.at/LjGEM 2) data scientist shorturl.at/nDdhQ Please share! 🙌 We look forward to your application! 🤩

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Ellenberg Lab @ellenberglab.bsky.social · 09/01/2025

Congratulations to @andibrunner.bsky.social and the team, and many thanks to the lab of Jan-Michael Peters for support! We found that the interphase and mitotic chromatin loop organization have more in common than previously thought: In both stages big loops are built first, small ones second

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Reposted by Ellenberg Lab

Andi Brunner @andibrunner.bsky.social · 09/01/2025

My first own project is published: Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar A new data resource and new insights into human chromatin biology! 🧬🥳

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Ellenberg Lab @ellenberglab.bsky.social · 16/12/2024

Our excellent postdoc Wanlu Zhang is at #CellBio24 and will talk about her unpublished NPC biogensis work tomorrow! Check it out and say hello 🙌🏼

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Ellenberg Lab @ellenberglab.bsky.social · 25/11/2024

We are now on Bluesky! Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku

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