The European Genome-phenome Archive (EGA) is a service for permanent archiving and sharing of all types of personally identifiable genetic and phenotypic data resulting from biomedical research projec...

Epigenetic biallelic inactivation in prostate cancer remains to be explored. Here, the authors develop a computational method Epi2Hit that integrates the hemizygous genomic disruptions with patterns o...

Tissue-anchored cell-free DNA methylation signatures enable minimally invasive detection, cancer-type distinction, and estrogen receptor classification in metastatic breast cancer, offering an interpr...

Signal Transduction and Targeted Therapy - IFNAR1-dependent metabolic circuit drives pathogenic neutrophil activation in chronic mucosal inflammation

Signal Transduction and Targeted Therapy - Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer

Analysis of cell samples from pneumonia patients may indicate specific phenotypes associated with disease. Here the authors use a multi-omics approach to analyse transcriptional pneumotypes in severe ...

Mutually exclusive SMAD4 and TGFBR2 alterations distinguish metastatic and localized evolutionary paths in pancreatic ductal adenocarcinoma, while radiated tumors show greater genomic heterogeneity, s...

This paper presents a sizeable single-cell multi-omic analysis of meningiomas comprising more than seven million cells. The results highlight tumor-intrinsic heterogeneity within both malignant and st...

Signal Transduction and Targeted Therapy - Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis

Microglia cellular changes underlie divergent resilience-associated mechanisms in human aging.

The Federated EGA (FEGA) Metadata Working Group (MWG) has designed a new, process-oriented metadata model intended to replace the EGA v1 model, used by Central EGA (CEGA) and FEGA nodes using Local EG...

This documentaion will provide information on how to use the cBioPortal during the submission process and data access.

Knowledge base for onboarding to the Federated EGA network.

YouTube video by European Genome-phenome Archive (EGA)

The ELIXIR All Hands meeting is an annual event that brings together members of the ELIXIR community. The goal of the event is to review ELIXIR’s achievements and activities so far, and discuss...

Federated EGA Affiliates: What are they and why create one? Date: Wednesday 10 June, 11am CEST Room, capacity: Rhone 1 (tables of 10, 60 people) Chair: Teresa D'Altri Link to joint...

Bridging gaps: from ELIXIR Science Tier to User Value Date: Monday, 8 June 2026 Time: 14:00-15:30 Room: Auditorium Pasteur Chairs: Mark Ibberson, ELIXIR Switzerland and Magda Chegkazi, ELIXIR Hub A...

30 million people in Europe live with a rare disease. Yet most still lack a diagnosis or treatment. So what is ERDERA doing about it?

The European Genome-phenome Archive (EGA) is a service for permanent archiving and sharing of all types of personally identifiable genetic and phenotypic data resulting from biomedical research projec...

Mitochondrial DNA mutations shape human phenotypes, yet mapping mutational landscapes in single cells remains challenging. Here, Hsieh et al. quantify mutational load and mosaicism, revealing constrai...

Intrahepatic cholangiocarcinoma has poor survival due to frequent recurrence and limited prognostic markers. Here, the authors identify two prognostic proteomic tumor clusters, validate a classifier a...

Desmoplastic small round cell tumor (DSRCT), a very rare and understudied sarcoma, presents serious challenges for both diagnosis and treatment. Here, the authors employ multi-omics profiling on 30 re...

Biomarker Research - The murine C1498 cell line is one of the most widely used syngeneic models to investigate acute myeloid leukemia (AML) pathogenesis, tumor-host interactions and therapeutic...