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Dynamic42

@dynamic42.bsky.social
75 followers 51 following 219 posts

Recreating human physiology in vitro for better therapies and disease research without animal experiments. Posting about news and insights from the organ-on-chip world. Learn more about us here --> dynamic42.com

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Dynamic42 @dynamic42.bsky.social · 29/09/2026
UK is calling 🇬🇧 Join our Organ-on-Chip workshops in Sheffield (12 Oct) or Nottingham (13 Oct) to get hands-on experience with our platform or meet us at ELRIG Drug Discovery 2026 in London, 14–15 Oct, booth C04 to learn how organ-on-chip can improve drug development pipelines.
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Dynamic42 @dynamic42.bsky.social · 28/09/2026
Last week, Marty had the opportunity to showcase our Organ-on-Chip technology at the Organ-on-Chip MasterClass by AZAR Innovations in Utrecht. Our commercial demonstration with hands-on session was filled with plenty of discussion and new opportunities. Thank you for hosting us!
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Dynamic42 @dynamic42.bsky.social · 24/09/2026
Part 12 of Minds Behind Organ-on-Chip season 2 features Dr. Fatina Siwczak, who shares insights into her work on establishing a sebum-producing skin-on-chip model to better understand the functionality of the sebaceous gland. Watch here: zurl.co/zczrs
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Minds Behind Organ-on-Chip - Dr. Fatina Siwczak (Leipzig University, Germany)
We had the opportunity to speak to Fatina a Postdoc at the Institute for Veterinary Physiology at Leipzig University in Germany. Her working group is focussi...
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Dynamic42 @dynamic42.bsky.social · 17/09/2026
Next stop: Graz!  At Myk2026, join us at Booth 6 and learn about our latest work on fungal infection models and antifungal therapies and discover our newest additions to the DynamicOrgan® product series. #organonchip #infection #MYK2026
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Dynamic42 @dynamic42.bsky.social · 16/09/2026
Final day at #EUROTOX2026! Working in toxicology, drug safety or pharmacokinetics and excited about animal-free approaches? Today is the last day to visit us at booth 84. Come by, say hello to our team and find out how our organ-on-chip solutions can support toxicology research.
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Dynamic42 @dynamic42.bsky.social · 15/09/2026
This video of Minds Behind Organ-on-Chip season 2 features Adrian Feile, who shares insights into his work on DPO-dependent quorum sensing modulation of biofilms of Vibrio cholerae in an intestine-on-chip-model. Watch here: zurl.co/dNpsv
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Minds Behind Organ-on-Chip - Adrian Feile (University Hospital Jena)
We had the opportunity to speak Adrian Feile from the Moist Group at University Hospital Jena in Germany. He has shown that DPO (3,5-dimethylpyrazin-2-ol)-de...
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Dynamic42 @dynamic42.bsky.social · 11/09/2026
We’re heading to EUROTOX 2026 in Vienna! Meet us at Booth 84 and join Tim’s poster presentation on drug-induced #hepatoxicity in human liver-on-chip models. See our DynamicOrgan® systems plus live TEER & oxygen monitoring demos.  #EUROTOX2026 #toxicity #drugsafety #organonchip
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Dynamic42 @dynamic42.bsky.social · 09/09/2026
When your cells are precious or time-critical, preparation should be predictable. That’s why we are introducing a new version of our classic 2-Channel biochip: sterile and pre-coated with Collagen I, ready for cell seeding directly after arrival.
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Dynamic42 @dynamic42.bsky.social · 08/09/2026
We are delighted to welcome Corinna Schwarz to Dynamic42! Corinna has joined our Production team, bringing valuable hands-on experience in production, quality control and structured operational processes within regulated environments. More here: zurl.co/RoHW5
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Dynamic42 @dynamic42.bsky.social · 03/09/2026
Austria, here we come 🇦🇹  In September, you can meet us at EUROTOX 2026 in Vienna (Booth 84) and Myk2026 in Graz (Booth 6).  Learn more about our #organonchip solutions for #toxicology, #infection modeling #antifungal therapy. #EUROTOX2026 #MYK2026
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Dynamic42 @dynamic42.bsky.social · 01/09/2026
Part 10 of Minds Behind Organ-on-Chip season 2 features Puja Pandey, who shares insights into her work on establishing a system mimicking intestinal morphology and function to understand epithelial regeneration after infection and treatment. Watch here: zurl.co/2ea91
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Minds Behind Organ-on-Chip - Dr. Puja Pandey (Hannover Medical School, Germany)
We had the opportunity to speak to Puja a Postdoc from the Büttner Group at Hannover Medical School in Germany. She is working on different animal alternativ...
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Dynamic42 @dynamic42.bsky.social · 26/08/2026
Part 9 of Minds Behind Organ-on-Chip season 2 features Simranpreet Kaur, who shares insights into her work on developing a lung-on-chip model for the analysis of infection dynamics and host-pathogen interaction in invasive mucormycosis. Watch here: zurl.co/35lwn
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Minds Behind Organ-on-Chip – Simranpreet Kaur (Hans Knöll Institute (Leibniz-HKI), Germany)
We had the opportunity to speak to Simranpreet, PhD student at Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute) in...
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Dynamic42 @dynamic42.bsky.social · 25/08/2026
Last week we took a well-deserved break for some team building. We explored a slackline course, cooked over open fire, tried archery & made energy balls. The retreat reminded us how much stronger our work becomes when we communicate clearly & tackle challenges together.
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Dynamic42 @dynamic42.bsky.social · 24/08/2026
Last chance! Our summer sale is ending on 31 August! ☀️ Get our DynamicOrgan® Starter Kits for under €500, including free 2-month Online Academy access. Terms & Conditions apply Learn more here: zurl.co/L3iPU
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Dynamic42 @dynamic42.bsky.social · 19/08/2026
Ready-to-seed - Introducing our new sterile 2-Channel biochips pre-coated with Collagen I. Instead of preparing the biochip yourself, you can start with a sterile, Collagen I-coated chip and focus on what matters most: building your organ model.
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Dynamic42 @dynamic42.bsky.social · 18/08/2026
Part 8 of Minds Behind Organ-on-Chip season 2 features Sara Matos, who shares insights into her work on developing a gut-on-chip model to study the factors driving the transition of Bilophila wadsworthia from commensal to pathogen. Watch here: zurl.co/jmp6n
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Minds Behind Organ-on-Chip – Sara Matos (ITQB Nova, Portugal)
We had the opportunity to speak to Sara, PhD student at ITQB NOVA in Portugal. She is working on developing a gut-on-chip model to study the factors that dri...
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Dynamic42 @dynamic42.bsky.social · 13/08/2026
Our new webshop is live 🚀 Shop our DynamicOrgan® products with product info, specs and order tracking in one place. Registration is available for customers in the EU, except of the regions covered by our distributors. Want to get started? 👉 Simply sign up and start exploring.
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Dynamic42 @dynamic42.bsky.social · 11/08/2026
Part 7 of Minds Behind Organ-on-Chip season 2 features Alexandra, who talks about her work on evaluating a drug delivery system for post-surgical treatment of glaucoma by mimicking the aqueous humor flow in the eye inside a microfluidic chip. Watch here: zurl.co/DcYSc
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Minds Behind Organ-on-Chip – Alexandra Oliveira (NOVA Medical School, Portugal)
We had the opportunity to speak to Alexandra, PhD student at NOVA Medical School in Lisbon, Portugal. She is working on developing a drug delivery system for...
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Dynamic42 @dynamic42.bsky.social · 04/08/2026
Part 6 of Minds Behind Organ-on-Chip season 2 features Hristina Koceva, who shares insights into her work on establishing a human iPSC-based alveolus-on-chip model to study immunometabolic modulation during Influenza A infection. Watch here: zurl.co/iJIZ4
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Minds Behind Organ-on-Chip – Hristina Koceva (Mosig Lab, University Hospital Jena, Germany)
We had the opportunity to speak to Hristina, PhD at the Mosig Lab at University Hospital Jena in Germany. She is working on establishing a human iPSC-based a...
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Dynamic42 @dynamic42.bsky.social · 30/07/2026
Summer heat? High. Starter Kit price? Low. ❄️ Get started with DynamicOrgan® Starter Kits for under €500 and receive free 2-month Online Academy access. Valid until 31 Aug 2026. Terms & Conditions apply Learn more here: zurl.co/hcuZ1
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Dynamic42 @dynamic42.bsky.social · 28/07/2026
Part 5 of Minds Behind Organ-on-Chip season 2 features Christian Maass, lead of MPSlabs at ESQlabs. Chris shares insights into our joint project on predicting drug safety during pregnancy by combining MPS in vitro data with digital twinning. Watch here: zurl.co/w6fat
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Minds Behind Organ-on-Chip - Christian Maass (MPSlabs, BU of ESQlabs GmbH, Germany)
We had the opportunity to speak to Christian Maass, Lead of MPSlabs, a business unit of ESQlabs GmbH in Germany. Chris talks about our joint project on predi...
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Dynamic42 @dynamic42.bsky.social · 21/07/2026
Part 4 of Minds Behind Organ-on-Chip season 2 features Dr. Nanci dos Santos Ferreira from KU Leuven in Belgium, who shares insights into Hepatitis E Virus (HEV) replication and dissemination in a human enteroid-derived gut-on-chip model. Watch here: zurl.co/laM1I
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Minds Behind Organ-on-Chip - Dr. Nanci dos Santos Ferreira (Porto Lab, KU Leuven, Belgium)
We had the opportunity to speak to Nanci, PostDoc at the Porto Lab at KU Leuven in Belgium. She is working on the development of an human intestinal enteroi...
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Dynamic42 @dynamic42.bsky.social · 17/07/2026
We are at the JSMC Retreat 2026 in Jena! Meet our colleague Franzi to learn how organ-on-chip technology can support microbiology and infection biology research with human-relevant in vitro models. We’re excited to connect with the JSMC community! #organonchip #infection #jsmc
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Dynamic42 @dynamic42.bsky.social · 16/07/2026
No need to let organ-on-chip adoption make you sweat. ☀️ Our DynamicOrgan® Starter Kits are available for under €500 this summer, including free 2-month Online Academy access. Terms & Conditions apply Learn more here: zurl.co/UsxRX
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Dynamic42 @dynamic42.bsky.social · 14/07/2026
Part 3 of Minds Behind Organ-on-Chip season 2 features Markus Gresnikt, who shares insights into host pathogen interactions during the infection with the yeast Candida albicans in gut- and vaginal mucosa-on-chip models. Watch here: zurl.co/OQ5D0
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Minds Behind Organ-on-Chip - Dr. Mark Gresnigt (Hans Knöll Institute (Leibniz-HKI), Germany)
We had the opportunity to speak to Mark the Junior Research Group Leader of the Adaptive Pathogenicity Strategies group at the Leibniz Institute for Natural ...
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Dynamic42 @dynamic42.bsky.social · 09/07/2026
Choosing the right biochip format is an important step when building an organ model. Different research questions require different microenvironments from compartmentalized co-cultures & 3D spheroid models to integrated sensor readouts for barrier integrity or oxygen monitoring.
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Dynamic42 @dynamic42.bsky.social · 07/07/2026
Part 2 of Minds Behind Organ-on-Chip season 2 features Nicole Engert, who shares insights into a stem cell-derived gut-on-chip technology to elucidate human norovirus infections. Watch here: zurl.co/zjR9k
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Minds Behind Organ-on-Chip - Dr. Nicole Engert (University Hospital Jena, Germany)
We had the opportunity to speak to Nicole a PostDoc in the research group, AG Inspire at the University Hospital Jena in Germany. She is working on a stem ce...
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Dynamic42 @dynamic42.bsky.social · 02/07/2026
Minds Behind Organ-on-Chip is back for season 2! In part 1, Maria Warschinke shares her work on an immunocompetent intestine-on-chip model for Clostridioides difficile infection in a hypoxic microenvironment. Watch here: zurl.co/2sli0
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Minds Behind Organ-on-Chip - Maria Warschinke (University Hospital Jena, Germany)
We had the opportunity to speak to Maria a PhD student in the research group, AG Inspire at the University Hospital Jena in Germany. She is working on an imm...
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Dynamic42 @dynamic42.bsky.social · 30/06/2026
We’re excited to welcome Darlin Lantigua as Dynamic42’s new Field Application Specialist in the United States. We’re strengthening local support for researchers implementing advanced organ-on-chip applications with our DynamicOrgan® platform. More here: zurl.co/p5UHu
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Dynamic42 @dynamic42.bsky.social · 24/06/2026
It’s hot outside — but your lab budget doesn’t have to sweat. ☀️ DynamicOrgan® Starter Kits are available this summer for under €500, including free 2-month Online Academy access. Terms & Conditions apply Learn more here: zurl.co/j3v0G
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Dynamic42 @dynamic42.bsky.social · 18/06/2026
Few days until #EUROoCS2026. Where to find us: 1️⃣ Poster T-126: PDAC-on-chip with T cell modulation 2️⃣ Talk: Real-time O2 + TEER measurement in a gut-on-chip model 3️⃣ Live demo with PyroScience: Come to booth #G3 to see our O₂ sensor system in action.   #organonchip
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Dynamic42 @dynamic42.bsky.social · 17/06/2026
Last call - tomorrow 4 PM CET! Don’t miss “Advanced BBB on Chip Models for Brain Cancer Research” - June 18, 2026 (4 PM CET). Talks + panel on tumor–BBB interactions and drug transport & efficacy testing. Register: zurl.co/FkL3f
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Dynamic42 @dynamic42.bsky.social · 16/06/2026
Some researchers hesitate because they think #OrganOnChip is too complicated. However, as with any new technology, with a step-by-step approach and well-thought-out experimental design, this can soon become a staple method in your lab. Or as Joanna says : "You will be just fine"!
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Dynamic42 @dynamic42.bsky.social · 11/06/2026
1 week left! June 18, 4 PM CET: Advanced BBB on Chip Models for Brain Cancer Research. 🎯 Highlights: • BBB on Chip model setup & optimization • Tumor–BBB interactions (glioma & beyond) • Drug transport & efficacy testing across the BBB Register: zurl.co/cQKad
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Dynamic42 @dynamic42.bsky.social · 10/06/2026
Based in Berlin or nearby? Join us at the Networking Event on Human 3D Organ Models organized by Charité 3R and Einstein Center 3R. Discover our organ-on-chip platform and meet Marty to discuss applications for human-relevant research and 3R-aligned innovation.
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Dynamic42 @dynamic42.bsky.social · 09/06/2026
How do we achieve reproducible TEER measurements? 1️⃣ fixed, planar electrodes for consistent positioning 2️⃣ measurements inside the incubator to minimize temperature variations
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Dynamic42 @dynamic42.bsky.social · 04/06/2026
Oxygen inside chips used to be a black box. Now, integrated optical sensors allow continuous, non-invasive O₂ monitoring under flow. This reveals real time metabolism, drug effects & true physiological conditions. A core biological parameter for in vitro models.
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Dynamic42 @dynamic42.bsky.social · 02/06/2026
[New AppNote] Immunocompetent Gut-on-Chip for toxin testing This AppNote describes an Intestine-on-Chip (i-IoC) model as a testing platform for toxic substances, including bacterial toxins and their protective correlates. Download here: zurl.co/ItUX3
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AppNote-intestine-Clostridioides-Toxin.pdf
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Dynamic42 @dynamic42.bsky.social · 27/05/2026
How can we build more predictive, human-relevant in vitro models for disease & cancer research? Visit our posters at #MPS2026 today: #Poster 336: Non-invasive #TEER monitoring in a 3D intestine-on-chip model #Poster 369: Micro-vascularized PDAC-on-chip with T cell modulation
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Dynamic42 @dynamic42.bsky.social · 26/05/2026
How much oxygen are cells exposed to inside organ-on-chip models?  Together with PyroScience, we developed the first integrated organ-on-chip platform with non-invasive real-time O₂ sensing. See it live at #MPS2026 📍 Booth 515/517 ☕ Demo schedule: zurl.co/ojj6T
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Dynamic42 @dynamic42.bsky.social · 26/05/2026
We’ve arrived in Washington, DC and can’t wait to see you at #MPS2026! Today: #TEER & #oxygen measurement live with Tom & Amélie Tomorrow: Posters on integrated TEER + PDAC-on-chip Daily: Live oxygen sensor demos at Booth 515/517 with PyroScience Excited to exchange ideas!
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Dynamic42 @dynamic42.bsky.social · 22/05/2026
Beyond endpoint assays: how do you track real tissue dynamics in organ-on-chip systems? Join our educational workshop at #MPS2026 to explore real-time TEER and O₂ monitoring — with hands-on training in biochip handling, seeding, perfusion setup, and live readouts. #TEER #Oxygen
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Dynamic42 @dynamic42.bsky.social · 21/05/2026
Join us June 18, 2026 (4 PM CET) for “Advanced BBB on Chip Models for Brain Cancer Research” with EPO Berlin Buch. Talks + expert panel on tumor, BBB interactions & drug transport/efficacy testing. Register: zurl.co/J6064 #BloodBrainBarrier #OrganOnChip
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Dynamic42 @dynamic42.bsky.social · 19/05/2026
In IBD, loss of butyrate during dysbiosis may weaken mucosal defense against C. albicans. With a Colitis-on-Chip the authors showed butyrate strengthens barrier integrity & boosts macrophage antifungal defense while limiting inflammatory damage. Summary: zurl.co/5F0IS
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Dynamic42 @dynamic42.bsky.social · 13/05/2026
Two weeks until #MPS2026. What you shouldn’t miss: 1️⃣ Educational Workshop: Perform TEER/O₂ live readouts in Dynamic42 biochips 2️⃣ Live demo with PyroScience: Come to booth #515 to see our O₂ sensor system in action. 3️⃣ Posters: TEER for gut-on-chip + PDAC-on-chip
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Dynamic42 @dynamic42.bsky.social · 12/05/2026
What makes the DynamicOrgan® TEER-Sensor Kit different to existing solutions? 👉 Learn more about the DynamicOrgan® TEER-Sensor Kit here: zurl.co/WXXNw #MPS #NAMs #OrganOnChip #DrugDiscovery #NextGenModels #lungonchip #gutonchip #TEER
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Dynamic42 @dynamic42.bsky.social · 11/05/2026
[New Paper] A microbiota-derived metabolite, a human colitis-on-chip, and a new angle on IBD barrier repair. Congratulations to Tim Kaden et al. on this recent publication in Frontiers in Immunology. Read the article here: zurl.co/zSo6m
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Dynamic42 @dynamic42.bsky.social · 07/05/2026
[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Beyond endpoints - Real-time insights into barrier dynamics with TEER in organ-on-chip Read it here: zurl.co/eROQU
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Real-time insights into barrier dynamics with TEER
This blog compares different methods for assessing barrier permeability in in vitro models addressing limitations of traditional endpoint assays.
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Dynamic42 @dynamic42.bsky.social · 29/04/2026
Connect with us at #BioEquity Europe in Prague.  As organ-on-chip technology continues to advance, it is reshaping how complex biological systems are studied. Meet Wolfgang and Knut to discuss how our solutions can improve pre-clinical decision making and accelerate workflows.
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Dynamic42 @dynamic42.bsky.social · 28/04/2026
What equipment is needed to measure TEER inside our organ models? If you are new to organ-on-chip all you need is the DynamicOrgan® TEER-Sensor System Beginner containing: / DynamicOrgan® TEER-Sensor Kit / Peristaltic pump / tighTEER T-31 readout unit + a Computer
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