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Dave Weisman

@dweisman.bsky.social
746 followers 635 following 524 posts

Amylysis. Skeptical doesn’t mean cynical.

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Dave Weisman @dweisman.bsky.social · 16/04/2026
The methods betray a motivation to dilute positive studies with negative ones. We've seen this in the past as a pathetic attempt to dismiss the efficacy of these drugs. www.nytimes.com/2026/04/15/h...
nytimes.com
Analysis of Alzheimer’s Drugs Stirs Debate About Their Effectiveness
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Dave Weisman @dweisman.bsky.social · 05/03/2026
Lithium in MCI, regardless of amyloid status, failed. I'm sure this will live on because including those with AB- keeps the door open to the (unlikely) idea it could work in AB+. jamanetwork.com/journals/jam...
jamanetwork.com
Low-Dose Lithium for Mild Cognitive Impairment
This pilot randomized clinical trial evaluates the feasibility, safety, and methodological considerations of low-dose lithium treatment in older adults with mild cognitive impairment.
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Reposted by Dave Weisman
The New Yorker @newyorker.com · 19/02/2026
Short sleepers, who make up less than one per cent of the population, spend significantly less than eight hours snoozing without any apparent health consequences. What can these rare individuals teach us about our relationship with rest? newyorkermag.visitlink.me/WQhwQk
newyorkermag.visitlink.me
Why Some People Thrive on Four Hours of Sleep
Short sleepers, who make up less than one per cent of the population, spend significantly less time snoozing without any apparent health consequences.
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Dave Weisman @dweisman.bsky.social · 11/01/2026
Read this if you are into Alzheimer's disease. It will help reframe your mind.
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Dave Weisman @dweisman.bsky.social · 08/01/2026
"Function says it is not a medical provider." So what IS it? www.nytimes.com/2026/01/08/w...
nytimes.com
The Rise of the Self-Serve Blood Test
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Dave Weisman @dweisman.bsky.social · 22/12/2025
Onwards!
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Dave Weisman @dweisman.bsky.social · 04/12/2025
Punk rock girl came on Pandora. How in the world had I not uploaded that song before? I’m questioning other decisions I’ve made.
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Dave Weisman @dweisman.bsky.social · 25/11/2025
Two AD failures in one day. Novo's semaglutide and the anti-tau mab posdinemab. Sad day for the field.
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Dave Weisman @dweisman.bsky.social · 24/11/2025
The Novo GLP trial failed in AD. Beware lack of mechanism and loss for repurposed drugs. www.neurologylive.com/view/glp-1-s...
neurologylive.com
GLP-1 Semaglutide Fails to Outperform Placebo in Phase 3 EVOKE Trial of Alzheimer Disease | NeurologyLive - Clinical Neurology News and Neurology Expert Insights
Results from the EVOKE and EVOKE+ phase 3 studies reported that oral semaglutide did not significantly reduce clinical progression in patients with early symptomatic Alzheimer disease.
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Dave Weisman @dweisman.bsky.social · 26/10/2025
Earned that poutine.
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Dave Weisman @dweisman.bsky.social · 25/10/2025
I love Canada. Got to speak at the CAGP-CCSMH 2025 Annual Scientific Meeting.
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Dave Weisman @dweisman.bsky.social · 03/10/2025
Weird case of Oxytocin helping with agitation. journals.sagepub.com/doi/10.1177/...
journals.sagepub.com
Intranasal Oxytocin for Managing Agitation in a Patient of Mixed Dementia With Multiple Pathologies, Particularly With a History of Repetitive Head Injuries - Naresh Jadav, Sümeyye Kuş, James Ellison,...
Background Agitation is common in persons living with dementia (major neurocognitive disorder) and worsens with disease progression. Brexpiprazole is the sole F...
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Dave Weisman @dweisman.bsky.social · 25/09/2025
Wrapping up Vermont riding.
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Dave Weisman @dweisman.bsky.social · 11/08/2025
Another mouseheimer's paper blown up beyond all reason. Please, do not take Lithium for memory or Alzheimer's disease. wapo.st/47uJMrU
wapo.st
How lithium went from 7Up to treatment for mental illness — and maybe Alzheimer’s
A new study suggests lithium may play a crucial role in developing Alzheimer’s treatments, but the substance has long been used to treat mood disorders like bipolar disorder.
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Dave Weisman @dweisman.bsky.social · 21/07/2025
Check this conversation out on Neurology Live. www.neurologylive.com/peers-perspe...
neurologylive.com
Approaches and Considerations in Mild Cognitive Impairment Due to Alzheimer
Experts discuss the importance of early diagnosis in Alzheimer disease, and discuss the safety and efficacy of newer treatment options for mild cognitive impairment.
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Dave Weisman @dweisman.bsky.social · 15/07/2025
The basis of informed consent is falsifying medical records?
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Dave Weisman @dweisman.bsky.social · 11/07/2025
How to implement anti-amyloid therapies lecanemab or donanemab: practicalneurology.com/diseases-dia...
practicalneurology.com
Building an Infrastructure to Administer Amyloid-Targeting Treatments
With the introduction of amyloid-targeting therapies, clinicians face a paradigm shift, requiring new clinical systems, interdisciplinary teams, and exper…
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Dave Weisman @dweisman.bsky.social · 11/07/2025
New titration of donanemab is approved. Not aware of anyone who use the previous titration, but good to see this. www.biospace.com/policy/lilly...
biospace.com
Lilly Gets FDA Label Update for Alzheimer’s Drug To Mitigate Safety Concerns
The FDA will allow a new dosing schedule for Eli Lilly’s Alzheimer’s drug Kisunla that could lessen a known side effect of the monoclonal antibody drug class that has led to several deaths.
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Dave Weisman @dweisman.bsky.social · 04/07/2025
This entire Sage story added nothing to patient care or to the economy. Just wasted efforts to rearrange the deck chairs. Then set all the staff adrift. www.biospace.com/business/sag...
biospace.com
Sage’s Search for Lifeline Ran Into Defiant Biogen CEO
After the FDA rejection of Zurzuvae in one type of depression and the triple failure of neuro asset dalzanemdor, Sage was searching for a path forward at the end of December 2024. Biogen CEO Chris Vie...
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Dave Weisman @dweisman.bsky.social · 28/06/2025
I did a thing for Medscape. Very good patient-physician interactions, and the structure and thinking behind those conversations. www.medscape.org/sites/pwr/ad...
medscape.org
Life in the Dementia Clinic: Contextualizing Treatment Options for Early Stages of Alzheimer's Disease
Unlock Better Conversations: Guiding Patients Through Benefits and Risks of Anti-Amyloid Alzheimer's Therapy
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Dave Weisman @dweisman.bsky.social · 25/06/2025
How many humans will die as a result of this? Pathogens don't respect borders. www.nytimes.com/2025/06/25/h...
nytimes.com
Kennedy Withdraws Funding Pledge to International Vaccine Agency
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Dave Weisman @dweisman.bsky.social · 25/06/2025
Can the UK legislate itself to biotech greatness? At least they're trying. www.fiercepharma.com/pharma/uk-la...
fiercepharma.com
UK lays out strategy to become a top 3 life sciences economy by 2035
With a goal of boosting its life sciences economy into the top three of the global rankings by 2035, the U.K. | With a goal of boosting its life sciences economy into the top three of the global ranki...
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Dave Weisman @dweisman.bsky.social · 05/06/2025
Incrementalism works. This is great news. www.nytimes.com/2025/06/03/h...
nytimes.com
From No Hope to a Potential Cure for a Deadly Blood Cancer
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Dave Weisman @dweisman.bsky.social · 29/05/2025
This comes up all the time. Great idea, I hope this is implemented widely.
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Dave Weisman @dweisman.bsky.social · 29/05/2025
"Unless these journals change dramatically, we are going to stop NIH scientists from publishing there, and we're going to create our own journals... They're going to become the pre-eminent journals, because if you get NIH funding, it is anointing you as a good, legitimate scientist." -K Jr. What?
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Dave Weisman @dweisman.bsky.social · 22/05/2025
Excellent takedown of an Alzheimer’s quack. My only critique of the piece is that we need more photos of that cat. Great job @nytimes.com - almost making up for the APOE article. www.nytimes.com/2025/05/21/w...
nytimes.com
An Expensive Alzheimer’s Lifestyle Plan Offers False Hope, Experts Say
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Dave Weisman @dweisman.bsky.social · 19/05/2025
A pediatrician at Feinberg Northwestern just denied an amyloid PET scan on the phone with me. Does this world even make sense anymore?
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Dave Weisman @dweisman.bsky.social · 14/05/2025
The Wash U lecanemab paper is a hard act to follow. But here’s a combo experience with a private clinic and U Wash. link.springer.com/article/10.1...
link.springer.com
Monoclonal antibody administration in an academic institution and private neurological practice: a tale of two clinics - Journal of Neurology
The emergence of monoclonal antibody (MABs) drugs since the FDA approval of lecanemab has resulted in dramatic changes in the clinical approach and management of early-stage Alzheimer’s disease (AD). ...
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Dave Weisman @dweisman.bsky.social · 12/05/2025
Probably the best data since lecanamab RCT and OLE on patient safety. @suzanneeschindler.bsky.social et al did RCT level trial work on every patient getting leqembi with HUGE n, kept things boring, with many lessons learned here. jamanetwork.com/journals/jam...
jamanetwork.com
Lecanemab Treatment in a Specialty Memory Clinic
This study examines the feasibility and safety of treating patients in specialty memory clinics with lecanemab.
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Dave Weisman @dweisman.bsky.social · 04/05/2025
The slow twitch muscles let me down. But I’m proud of this epic ride. strava.app.link/z8ZsTQqi6Sb
strava.app.link
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Dave Weisman @dweisman.bsky.social · 03/05/2025
I’m up in the mountains of Denver. Trails going up need oxygen.
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Dave Weisman @dweisman.bsky.social · 27/04/2025
WIth 94 sequential patients on lecanemab, what did we learn? www.vumedi.com/video/real-w...
vumedi.com
Real-World Experience With Long-Term Lecanemab Treatment: A Retrospective Chart Review in Early Alzheimer's Disease
A video from David Weisman, posted on Apr 17, 2025.
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Dave Weisman @dweisman.bsky.social · 26/04/2025
New point when doing insurance “peer to peers.”
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Dave Weisman @dweisman.bsky.social · 26/04/2025
The poisons we should worry about more than sugar. www.washingtonpost.com/nation/2025/...
washingtonpost.com
USDA rolls back plans to limit salmonella levels in raw chicken, turkey
The agency said the Biden-era proposal would have been a burden on businesses. Food-safety experts criticized the decision as an unwillingness to protect the public.
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Dave Weisman @dweisman.bsky.social · 24/04/2025
Amazing work. Dissociate amyloid from tau, could be huge effect.
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Dave Weisman @dweisman.bsky.social · 24/04/2025
Check this out, two learned doctors talking anti-amyloid therapies, lecanemab and donanemab, some lessons learned, hopefully some nuggets of wisdom. www.neurologylive.com/peers-perspe...
neurologylive.com
Approaches and Considerations in Mild Cognitive Impairment Due to Alzheimer
Experts discuss the importance of early diagnosis in Alzheimer disease, and discuss the safety and efficacy of newer treatment options for mild cognitive impairment.
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Dave Weisman @dweisman.bsky.social · 22/04/2025
Tell it to the face of a kid with cystic fibrosis, “you are not patriotic.” www.latintimes.com/dr-oz-ridicu...
latintimes.com
Dr Oz Ridiculed for Advising Americans to Use Less Drugs to Reduce Drug Spending: 'Tell That to a Diabetic'
As Dr. Mehmet Oz was sworn in as head of Medicare and Medicaid, he encouraged Americans to reduce drug spending by simply staying healthy.
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Dave Weisman @dweisman.bsky.social · 21/04/2025
IBX will not cover lecanemab unless the person has Medicare? So people with early Alzheimer's, the same disease, suffer age discrimination. How is this legal?
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Dave Weisman @dweisman.bsky.social · 19/04/2025
I was expecting this question to be answered in the negative. Is my brain broken by expecting internet contrarians? www.sciencedirect.com/science/arti...
sciencedirect.com
Are Appropriate Use Recommendations useful in clinical practice?
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Dave Weisman @dweisman.bsky.social · 18/04/2025
Makary recently learned industry employed experts sit on ad coms, so perhaps he doesn't know they are non-voting members? Dismissing insight and expertise is never wise. www.statnews.com/2025/04/17/f... via @statnews.com
statnews.com
Makary says FDA will remove pharma representatives from advisory panels
Representatives from pharma and other industries already play a more limited role in advising the FDA.
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Dave Weisman @dweisman.bsky.social · 18/04/2025
Great thread on ARIA. Thanks!
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Dave Weisman @dweisman.bsky.social · 15/04/2025
Patient, "I called the guy on call last week, wow, he sounded stressed out. I said, 'hey, don't worry about me, I'll call back later.'" It is so weird and rare to have compassion flowing from patients towards doctors.
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Dave Weisman @dweisman.bsky.social · 15/04/2025
Great news today. Lecanemab approved in Europe. I quibble with the fact that genetic discrimination is permitted, but this probably won’t last long.
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Reposted by Dave Weisman
Nicolas Villain @nvillain-alz.bsky.social · 15/04/2025
Oh! It was finally approved today! 🍾🍾 ec.europa.eu/newsroom/san...
ec.europa.eu
HEALTH AND FOOD SAFETY - Commission authorises medicine for treatment of early Alzheimer’s disease
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Dave Weisman @dweisman.bsky.social · 11/04/2025
‘The Pitt’ does capture the overcrowding, but the ER docs do not use resources wisely, handingly palliative care and brain death instead of calling for consults. I'm only 3 episodes in though. Does it get better? www.nytimes.com/2025/04/10/h...
nytimes.com
‘The Pitt’ Captures the Real Overcrowding Crisis in Emergency Rooms
From the “chairs” to the hallway medicine, the show’s depiction of an emergency medicine system that is beyond capacity rings true for medical experts.
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Dave Weisman @dweisman.bsky.social · 08/04/2025
Not a man of action. More of an idea man. Not good ideas, but they are ideas.
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Dave Weisman @dweisman.bsky.social · 08/04/2025
Asians may not have as much ARIA. Really no clue why but I’m open to ideas. Limitations are present, but if this is seen in donanemab, would be more signal than noise.
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Dave Weisman @dweisman.bsky.social · 08/04/2025
He does the same in hallways! @renegadesynapse.bsky.social great bumping into you.
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Reposted by Dave Weisman
Stacey L. Clardy @staceylclardy.bsky.social · 05/04/2025
Dr. Trey Bateman @renegadesynapse.bsky.social of Wake Forest University School of Medicine giving a fast-paced, info-packed “Updates in Cognitive and Behavioral Neurology” at C10: Neurology Update at the @aanmember.bsky.social Annual Meeting. #AANAM
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Dave Weisman @dweisman.bsky.social · 02/04/2025
Big loss today. Alzheon overall trial was negative. But there were provocative findings. www.neurologylive.com/view/valiltr...
neurologylive.com
Valiltramiprosate Demonstrates Greater Promise in Milder Forms of Alzheimer Disease, Phase 3 APOLLOE4 Study Shows
Although valiltramiprosate failed to distinguish itself from placebo on the primary end point, the drug performed significantly better among mild MCI participants vs those with mild Alzheimer disease.
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