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Yvon Woappi

@drwoappi.bsky.social
25 followers 7 following 11 posts

Proud member of the #SyntheticRegeneration & Systems Physiology Laboratory woappilab.com

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Yvon Woappi @drwoappi.bsky.social · 22/08/2026
Excited to return to Barcelona to present our latest work on organ-scale wound regeneration at the 2026 GRC focused on Multi-Organ Communication. Equally thrilled at the opportunity to co-lead the New Technologies session! #SyntheticRegeneration
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Reposted by Yvon Woappi
Jaeseung Hahn @jaeseunghahn.bsky.social · 21/01/2026
Check out this beautiful work on mammalian wound healing! 🤯
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Yvon Woappi @drwoappi.bsky.social · 20/01/2026
Access the full preprint: www.biorxiv.org/content/10.6...
biorxiv.org
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Yvon Woappi @drwoappi.bsky.social · 20/01/2026
Mammals have repaired tissues for millions of years, yet the instruction manual for organ-scale coordination remained a mystery. We present he Organ Scale Wound Healing Atlas (OWHA)
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Irving Institute for Cancer Dynamics @cancerdynamics.bsky.social · 27/10/2025
Today we celebrate #NationalMentoringDay! Thank you to IICD researchers and mentors everywhere who dedicate their time to mentoring and inspiring the next generation of scientists.
Photo collage of scientists in the lab for National Mentoring Day
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Reposted by Yvon Woappi
Frankie D Heyward @frankiedheyward.bsky.social · 08/10/2025
I’m excited to share our new preprint! We built a single-nucleus multiomic (snRNA-seq+snATAC-seq) atlas of leptin receptor-expressing hypothalamic neurons (LepRᴴʸᵖᵒ) and identified conserved cis-regulatory elements overlapping human obesity-linked variants and eQTLs🧠🧬 www.biorxiv.org/content/10.1...
biorxiv.org
Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity
Leptin receptor-expressing hypothalamic neurons (LepRHypo) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We pr...
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
Immensely grateful to the @SynRegLab for this work! Congratulations to all authors!
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
TL;DR: Temporal control = cleaner, more accurate screens👍. 🔴CRISPR screens can hide true biology 🟢We introduce RESTRICT-seq, which activate Cas9 editing in precise time windows 🔵This revealed a hidden cancer resistance gene, PAK1, missed by standard CRISPR screening methods
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
Notably, PAK1 was upregulated EXCLUSIVELY in FGFR-negative patient tumors, and PAK1 inhibitors re-sensitized human + mouse metastatic SCC cells to anti-FGFR therapy; a strong therapeutic synergy.
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
Most importantly, RESTRICT-seq UNIQUELY flagged PAK1 as a key resistance driver — completely invisible by standard CRISPR screens, buried under the noise of non-specific gene dropouts. This is the power of #PrecisionGenomics: drug-synergistic vulnerabilities clearly revealed.
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
When compared to conventional wtCas9 screens, the difference was striking! RESTRICT-seq reduced clonal drift, ensuring gRNA counts reflect true biology; less artifacts!
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
To achieve this we engineered arCas9-SPARK, a live-cell biosensor that lets us track Cas9 movements in and out of the nucleus in real-time. It's fast⚡️: In and Out within 15 min!
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Yvon Woappi @drwoappi.bsky.social · 23/09/2025
Excited to share the latest preprint from my lab! We present RESTRICT-seq, a novel method for precision CRISPR screen! www.biorxiv.org/content/10.1...
biorxiv.org
RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance
Cancer cell evasion of therapy is a highly adaptive process that undermines the efficacy of many treatment strategies. A significant milestone in the study of these mechanisms has been the advent of p...
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Reposted by Yvon Woappi
Whitney Gibbs @whitgibbs.bsky.social · 30/04/2025
My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Yvon Woappi @drwoappi.bsky.social · 22/04/2025
it is my distinguished honor to be this year's Spring Commencement Speaker at @PittBradford! To the Class of 2025: I’m thrilled to celebrate your journey, resilience, and the boundless potential ahead. Let’s honor this incredible milestone together! 🎓 www.pittwire.pitt.edu/accolades-ho...
pittwire.pitt.edu
Alumnus Yvon Woappi will speak at Pitt-Bradford’s commencement on May 4
The Columbia University professor researching wound healing and regeneration will also receive an Alumni Award of Distinction.
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