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drwillwatson.bsky.social

@drwillwatson.bsky.social
85 followers 105 following 25 posts
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drwillwatson.bsky.social @drwillwatson.bsky.social · 01/04/2025
www.nature.com/articles/s41... FRESH-UP study. Fluid restriction to 1.5L vs liberal intake in HF. NO difference in QoL over 3 months. NO increase in HF hospitalisation, diuretic doses, BNP or weight. BUT median NYHA II, mean EF 40%, median fruse 40mg.
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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/03/2025
www.jacc.org/doi/abs/10.1... I think the take home message here is "give more diuretics" but good to recap the different modalities, and I wonder if I under use tolvaptan?
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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/03/2025
www.ahajournals.org/doi/10.1161/... XBP1 and EDEM2 identified as protective against myocardial lipid accumulation and downstream hypertrophy, fibrosis and myocardial stiffness in a rodent model of HFpEF. Metabolic answers for metabolic conditions!
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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/02/2025
And check this out - the capacity of these hearts to take up more energetic substrate - their mitochondrial flexibility - correlated with how much these hearts remodelled after 6 months of cardiac resynchronisation therapy.
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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/02/2025
For patients on an insulin-glucose infusion, switching on CRT shifted these patients to a greater proportion of lipid metabolism (the patients on a fat infusion presumably already maxed out!) [NEFA = non-esterified fatty acids]
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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/02/2025
We performed paired arteriovenous sampling on CRT implant patients while monitoring pressure volume loops and coronary artery flow
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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/02/2025
Delighted to be joint first author on this work published in @ESC_Journals EHJ academic.oup.com/eurheartj/ad...
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drwillwatson.bsky.social @drwillwatson.bsky.social · 24/02/2025
In mice, Cannabidiol prevented heart failure via various linked means (preserved contractility, preserved calcium dynamics, preserved mitochondrial function), apparently facilitated by PPAR-gamma receptor www.jacc.org/doi/10.1016/...
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drwillwatson.bsky.social @drwillwatson.bsky.social · 24/02/2025
We're slowly unpicking immune mechanisms of heart failure. A remarkable finding here that patients with higher levels of chemokine-receptor-type-5 expression on circulating lymphocytes were less likely to respond to cardiac resynchronisation therapy www.jacc.org/doi/10.1016/...
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drwillwatson.bsky.social @drwillwatson.bsky.social · 23/02/2025
Interesting article - Critical Care Cardiology, its models of care delivery and training structures. www.ahajournals.org/doi/full/10....
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drwillwatson.bsky.social @drwillwatson.bsky.social · 18/02/2025
www.nature.com/articles/s41... the heart is a metabolic omnivore... some evidence that supplementing ketone into cardiac metabolism leads to it being metabolised and increasing cardiac contractility - a novel approach using carbon-13 labelling technology
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drwillwatson.bsky.social @drwillwatson.bsky.social · 09/01/2025
www.nejm.org/doi/full/10.... @nejm.org update on HFpEF from Theresa McDonagh incorporating an integrated approach to diagnosis and review of the treatments (check out those hazard ratios!)
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drwillwatson.bsky.social @drwillwatson.bsky.social · 08/12/2024
doi.org/10.1001/jama... great editorial poking holes in our belief in Aspirin. Primary prevention evidence doesn't exist and secondary prevention evidence, as we see here, is very flimsy.
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drwillwatson.bsky.social @drwillwatson.bsky.social · 07/12/2024
www.ahajournals.org/doi/10.1161/... Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy I'm not bright enough to be an immunologist but there is an interesting story developing about certain myocarditis being driven by T-cells and zoning in on Th17 cells.
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drwillwatson.bsky.social @drwillwatson.bsky.social · 07/12/2024
Lots to think about in new directions for cardiomyopathy. In particular, how can we test better, and how can we personalise treatment for cardiomyopathies? academic.oup.com/eurheartj/ar...
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