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drwillwatson.bsky.social @drwillwatson.bsky.social · 01/04/2025

www.nature.com/articles/s41... FRESH-UP study. Fluid restriction to 1.5L vs liberal intake in HF. NO difference in QoL over 3 months. NO increase in HF hospitalisation, diuretic doses, BNP or weight. BUT median NYHA II, mean EF 40%, median fruse 40mg.

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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/03/2025

www.jacc.org/doi/abs/10.1... I think the take home message here is "give more diuretics" but good to recap the different modalities, and I wonder if I under use tolvaptan?

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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/03/2025

www.ahajournals.org/doi/10.1161/... XBP1 and EDEM2 identified as protective against myocardial lipid accumulation and downstream hypertrophy, fibrosis and myocardial stiffness in a rodent model of HFpEF. Metabolic answers for metabolic conditions!

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drwillwatson.bsky.social @drwillwatson.bsky.social · 27/02/2025

Delighted to be joint first author on this work published in @ESC_Journals EHJ academic.oup.com/eurheartj/ad...

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drwillwatson.bsky.social @drwillwatson.bsky.social · 25/02/2025

Learning is contextual. Think about this when wondering how you teach the next generation of clinicians…

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drwillwatson.bsky.social @drwillwatson.bsky.social · 24/02/2025

In mice, Cannabidiol prevented heart failure via various linked means (preserved contractility, preserved calcium dynamics, preserved mitochondrial function), apparently facilitated by PPAR-gamma receptor www.jacc.org/doi/10.1016/...

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drwillwatson.bsky.social @drwillwatson.bsky.social · 24/02/2025

We're slowly unpicking immune mechanisms of heart failure. A remarkable finding here that patients with higher levels of chemokine-receptor-type-5 expression on circulating lymphocytes were less likely to respond to cardiac resynchronisation therapy www.jacc.org/doi/10.1016/...

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drwillwatson.bsky.social @drwillwatson.bsky.social · 23/02/2025

Interesting article - Critical Care Cardiology, its models of care delivery and training structures. www.ahajournals.org/doi/full/10....

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drwillwatson.bsky.social @drwillwatson.bsky.social · 18/02/2025

www.nature.com/articles/s41... the heart is a metabolic omnivore... some evidence that supplementing ketone into cardiac metabolism leads to it being metabolised and increasing cardiac contractility - a novel approach using carbon-13 labelling technology

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drwillwatson.bsky.social @drwillwatson.bsky.social · 04/02/2025

Anyone have any advice? Like a lot of cardiology trainees I have accumulated a breadth of skills and interests and can’t decide between them for the rest of my career. How have others managed this?

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drwillwatson.bsky.social @drwillwatson.bsky.social · 09/01/2025

www.nejm.org/doi/full/10.... @nejm.org update on HFpEF from Theresa McDonagh incorporating an integrated approach to diagnosis and review of the treatments (check out those hazard ratios!)

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drwillwatson.bsky.social @drwillwatson.bsky.social · 15/12/2024

Slightly interesting - myocyte calcium overload is responsible for arrhythmogenesis and declining cardiac function basically across cardiac diseases - these data links an insulin signalling pathway to this state www.ahajournals.org/doi/full/10....

ahajournals.org

American Heart Association Journals

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drwillwatson.bsky.social @drwillwatson.bsky.social · 08/12/2024

doi.org/10.1001/jama... great editorial poking holes in our belief in Aspirin. Primary prevention evidence doesn't exist and secondary prevention evidence, as we see here, is very flimsy.

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Reposted by @drwillwatson.bsky.social

Stephen Pettit @drstephenpettit.bsky.social · 07/12/2024

Predicted heart mass is the optimal metric for donor-recipient size matching in heart transplantation. But the maths is tough at 3am. Download our simple Heart Transplant Sizing App for free from the Apple Store. apps.apple.com/gb/app/heart...

apps.apple.com

‎Heart Transplant Sizing App

‎Size matching is an important consideration in heart transplantation. It is important to avoid implanting an under-sized heart. Size matching has historically been performed using donor and recipient...

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drwillwatson.bsky.social @drwillwatson.bsky.social · 07/12/2024

www.ahajournals.org/doi/10.1161/... Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy I'm not bright enough to be an immunologist but there is an interesting story developing about certain myocarditis being driven by T-cells and zoning in on Th17 cells.

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drwillwatson.bsky.social @drwillwatson.bsky.social · 07/12/2024

www.nature.com/articles/s41... immune checkpoint inhibitor myocarditis is becomming very well studied - the relationship with T-cells and their outcomes perhaps helps us understand myocarditis and cardiac inflammation.

nature.com

Immune responses in checkpoint myocarditis across heart, blood and tumour - Nature

The molecular characteristics of myocarditis associated with immune checkpoint inhibitors are described and potential biomarkers of onset and severity are identified.

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drwillwatson.bsky.social @drwillwatson.bsky.social · 07/12/2024

Lots to think about in new directions for cardiomyopathy. In particular, how can we test better, and how can we personalise treatment for cardiomyopathies? academic.oup.com/eurheartj/ar...

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