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Yao D Cai

@drummonk.bsky.social
19 followers 24 following 10 posts

Biologist, Drummer

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Reposted by Yao D Cai
Joanna Chiu @joanna-chiu.bsky.social · 24/06/2026
Happy World Circadian Day! Rise and Shine ☀️☀️
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Reposted by Yao D Cai
Joanna Chiu @joanna-chiu.bsky.social · 17/04/2026
@drummonk.bsky.social and I wrote a @plosbiology.org Primer to highlight a fantastic study by Aalim Weljie’s and Amita Sehgal’s groups that reveals time-of-day dependent activities of glucose metabolic pathways. journals.plos.org/plosbiology/...
journals.plos.org
Circadian clock gates diurnal glucose utilization
The circadian clock and cellular metabolism are tightly coupled. This primer discusses a recent PLOS study that elucidates how glucose metabolism changes over the course of the day in Drosophila and h...
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Yao D Cai @drummonk.bsky.social · 23/03/2026
Adaptation to daily environmental changes shaped self-sustained circadian oscillators. We wrote a dispatch on Current Biology to highlight the new papers from Carl Johnson and Michael Rust group. They found seasonal environmental changes select for self-sustained oscillators. Read their works!!
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Reposted by Yao D Cai
Sergio Hidalgo Sotelo @sergiohidalgo.bsky.social · 09/11/2025
Thrilled to share our new work! In this study, we have expanded on the role of the circadian clock in integrating seasonal environmental cues through splicing. Thanks to @joanna-chiu.bsky.social for the continuous mentorship and to all co-authors! www.biorxiv.org/content/10.1...
biorxiv.org
Splicing of a core clock gene regulates seasonal adaptations by a winter gating mechanism
Seasons bring changes to the environment. Many organisms adjust their physiology and behavior in response to seasonal changes in order to survive. Although the molecular mechanisms mediating the integ...
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Yao D Cai @drummonk.bsky.social · 07/10/2025
Thank you Fred! We have been influenced by many of your works.
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Yao D Cai @drummonk.bsky.social · 25/09/2025
4. O-GlcNAcylation also interacts with phosphorylation. (They both modify serine, threonine and tyrosine.)
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Yao D Cai @drummonk.bsky.social · 25/09/2025
3. Rhythmic O-GlcNAcylation directly modulates proteins involved in gene expression.
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Yao D Cai @drummonk.bsky.social · 25/09/2025
2. This rhythm is responsive to changes in mealtime. (So glad that TMT proteomics worked out for this PTM!)
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Yao D Cai @drummonk.bsky.social · 25/09/2025
1. Nuclear protein O-GlcNAcylation shows daily rhythms in mouse liver.
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Yao D Cai @drummonk.bsky.social · 25/09/2025
These led us to explore whether proteome-wide O-GlcNAcylation mediates the effect of mealtime in rhythmic liver gene expression. We found:
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Yao D Cai @drummonk.bsky.social · 25/09/2025
We started out asking how mealtime regulates genome-wide rhythmic gene expression. We knew several nutrient-sensitive pathways are involved. We knew O-GlcNAcylation, a nutrient-sensitive protein modification, modulates CLOCK, BMAL1 and PER2.
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Yao D Cai @drummonk.bsky.social · 25/09/2025
Our paper is published in PLOS Biology! journals.plos.org/plosbiology/.... What a long and rewarding journey with @joanna-chiu.bsky.social and many who are not on Bluesky.
journals.plos.org
O-GlcNAcylation of nuclear proteins in the mouse liver exhibit daily oscillations that are influenced by meal timing
The liver transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein O-GlcNAcylation in the mouse liver over the course of the day and in response to altered meal timing, t...
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Yao D Cai @drummonk.bsky.social · 16/06/2025
Hi everyone! Finally joined BlueSky and found everyone is here!! Starting my journey here with a clip of my drumming🤘Foot technique is challenging!!
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