Yao D Cai @drummonk.bsky.social · 25/09/2025We started out asking how mealtime regulates genome-wide rhythmic gene expression. We knew several nutrient-sensitive pathways are involved. We knew O-GlcNAcylation, a nutrient-sensitive protein modification, modulates CLOCK, BMAL1 and PER2. 120
Yao D Cai @drummonk.bsky.social · 25/09/2025These led us to explore whether proteome-wide O-GlcNAcylation mediates the effect of mealtime in rhythmic liver gene expression. We found: 130
Yao D Cai @drummonk.bsky.social · 25/09/20251. Nuclear protein O-GlcNAcylation shows daily rhythms in mouse liver. 120
