With so much attention on NIH lately, can’t help but bring up lack of research focus of #myalgicencephalomyelitis #MECFS by NIH over the years. It’s so low make you wonder if intentional content.iospress.com/articles/wor...
Dr Kevin Lee
@dr-kevinlee.com
1.7K followers 1.5K following 214 posts
Physician-Imager: endocrinology & nuclear medicine #AusMedSky www.linkedin.com/in/kevinleefracp
![Graphic abstract.
Results
Protocol #1: Standing heart rate was reduced (105 [99-116] beats/min vs 119 [105-130] beats/min; P < 0.001) and symptoms improved (P < 0.001), during AM-ON vs AM-OFF. Standing heart rate (P = 0.04) and symptoms (P = 0.004) increased when compression was removed after several hours. Protocol #2: Standing heart rate was reduced (84 [77-90] beats/min vs 89 [84-100] beats/min; P < 0.001), and symptoms improved (P = 0.03), during AM-ON vs AM-OFF. Standing heart rate (P = 0.02) and symptoms (P < 0.001) increased when compression was removed after several hours.
Conclusions
Commercially available compression tights reduced heart rate and symptoms both acutely and after several hours of use. This additional benefit persisted whether concomitant medications were used. (Compression Garments in the Community With POTS [COM-COM-POTS]; NCT04881318)](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:tqck4ssn7iz5xhs6quytnrwg/bafkreicum74qc4p5nwnocumetqydb2djijxfvw6iglqurgdqqqfo7q73zi)
![Methods: A comprehensive search was conducted on the Scopus, Medline, ClinicalTrials.gov, and Cochrane Library databases up until May 20th, 2024. This review incorporates RCTs that examine the comparison between LDN and placebo in fibromyalgia patients. We employed random-effect models to analyze the odds ratio and mean difference (MD) for presentation of the outcomes.
Results: A total of 4 RCTs with 222 fibromyalgia patients were incorporated. The results of our meta-analysis showed a significant reduction in pain scores (MD: –0.86, 95% confidence interval [CI]: –1.20, –0.51, P < 0.001, I2 = 33%) and higher increment in pressure pain threshold (MD: 0.17, 95% CI: 0.08, 0.25, P < 0.001, I2 = 0%) among fibromyalgia patients who received LDN than those who only received a placebo. The fibromyalgia impact questionnaire revised and pain catastrophizing scale did not differ significantly between the two groups. LDN was also associated with higher incidence of vivid dreams and nausea, but showed no significant difference with the placebo in terms of serious adverse events, headache, diarrhea, and dizziness.
Conclusions: This study suggests the efficacy of LDN in mitigating pain symptoms for fibromyalgia patients with a relatively good safety profile.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:tqck4ssn7iz5xhs6quytnrwg/bafkreid3d277qmsowk2jxzrnfcyvfjq5tkjvqhsozrvryluexqt4htqouy)
![Table 12. Examples of treatment methods without sufficient scientific evidence or without a medical or scientific basis in environmental medicine [5, 73, 160, 384, 512, 762].
Treatment methods without sufficient scientific evidence
Antifungal treatment not in line with guidelines
Detoxification therapy, e.g., with cholestyramine (CSM therapy)
Dietary changes
Homeopathic treatments
Symbiosis control
Treatment methods without a medical or scientific basis
Bioresonance therapy (Moratherapy)
Autologous blood and urine treatment
Holistic intestinal cleansing
Salt therapy
Clinical ecology procedures (e.g., provocation and neutralization test (PN test))](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:tqck4ssn7iz5xhs6quytnrwg/bafkreidqrxjoq7izwi3mranb7ey2zzopjikmbsk34kbs2ihg3fcsimysgq)
