Remodeling of the extracellular matrix (ECM), a complex structural and signaling network of the nervous system, is essential for CNS development, plasticity, and injury responses, yet how individual n...

Wnt signaling is activated in more than half of gastric cancers through a ligand-dependent manner. Here the authors show with mouse models that tumor-derived Wnt ligands activate liver stromal fibrobl...

CD44 function is not solely determined by its protein sequence, it is dynamically encoded by its glycosylation state. Glycan remodeling generates distinct functional receptor states that regulate lig...

Abstract. Nanoparticle (NP)-based drug delivery has been explored to improve the therapeutic index of anticancer agents by enhancing tumor accumulation and

Abstract The effect of the vasopressin V2 receptor agonist desmopressin (dDAVP), and diclofenac-induced blockade of prostaglandin (PG) synthesis on the state of the interstitial matrix in the renal in...

Wnt signaling is activated in more than half of gastric cancers through a ligand-dependent manner. Here the authors show with mouse models that tumor-derived Wnt ligands activate liver stromal fibroblasts to facilitate hyaluronan accumulation in the microenvironment, promoting gastric cancer liver metastasis.

Chronic pain is frequently accompanied by anxiety and other affective disturbances, but the molecular and cellular changes linking peripheral injury to persistent alterations in brain function remain ...

Scientific Reports - 4-Methylumbelliferone triggers early oxidative stress, bioenergetic rewiring, and remodeling of cell-surface N-glycosylation in glioblastoma cells

Respiratory syncytial virus (RSV) infection induces significant structural remodeling of the pulmonary extracellular matrix (ECM). While in vivo models demonstrate increased tissue synthesis of pre-a...

Hyaluronan (HA) is a principal component of the tumor glycocalyx in colorectal cancer (CRC). However, how the disease progression is linked to HA abundance and its nanoscale organization remains uncle...

Stiffening of the extracellular matrix, declining microvascular perfusion, and mitochondrial dysfunction reinforce one another to drive tissue aging. This perspective outlines a unifying matrix-vascular-metabolic axis and highlights potential entry points to preserve tissue resilience and function with age.

Multicellularity necessitated the evolution of cellular diversity and specialization, yet across organisms, the retention of cellular plasticity within defined physiological contexts is a recurring pr...

In the mature brain, the extracellular matrix (ECM) molecules derived from neurons and glia accumulate in spatially distinct extracellular compartments, incl...

PDF | The molecular weight (Mw) of hyaluronic acid (HA) polysaccharide essentially determines its roles from embryonic development to tumor... | Find, read and cite all the research you need on Resear...

The naked mole rat is a rodent, but it is “nothing like a mouse,” says biologist Vera Gorbunova from the University of Rochester Aging Research Center. The

Neuronal heterogeneity is a defining feature of complex neural circuits, where local differences in firing patterns, activity levels, and temporal dynamics shape information processing and emergent ne...

BackgroundApproximately one in three adults aged 65–74 years reports hearing difficulty, including age-related hearing loss (AHL, presbycusis). The C57BL/6 m...

BackgroundApproximately one in three adults aged 65–74 years reports hearing difficulty, including age-related hearing loss (AHL, presbycusis). The C57BL/6 m...

Aging is accompanied by arterial dysfunction, defined by impaired endothelial function and increased large artery stiffness, yet the contribution of the endothelial glycocalyx (eGC) and its constituen...

Aging is accompanied by arterial dysfunction, defined by impaired endothelial function and increased large artery stiffness, yet the contribution of the endothelial glycocalyx (eGC) and its constituen...

Loss-of-function mutations in the smpd1 gene cause acid sphingomyelinase deficiency (ASMD). Early neurodegeneration and lethality characterize its infantile neurovisceral form (type A). While neuronal...

Spatial proteomics technologies now profile cells and the extracellular matrix (ECM) together in situ. Yet analysis tools remain cell-centric, despite the ECM playing an essential role in health and d...

Hyaluronan-dependent EGFR–CD44 regulatory pathways are inhibited by EGFR, HA synthase (HAS), and hyaluronidase (HYAL) inhibitors in those tumors with low LMW HA production. In others, HA accumulation...

The classical approach to autism spectrum disorders (ASD) is often limited to considering their neuro-functional aspects. However, recent scientific literature has shown that ASDs also affect many bod...

npj Aging - Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

Cell Death & Disease - MASP1‑METTL3‑HAS2 axis aggravates liver fibrosis through HMW‑HA‑mediated senescence inhibition and LMW‑HA‑induced activation of...

Hyaluronan (HA) is a major glycosaminoglycan of the extracellular matrix that regulates cell migration, signaling, and tissue homeostasis. Its turnover is co...

Background Early identification of patients at risk of developing severe coronavirus disease 2019 (COVID-19) remains a major clinical challenge. Hyaluronic acid (HA), a key component of the extracel...

Glioblastoma (GBM) is defined by infiltration of tumor cells throughout the brain, which drives resistance, recurrence and mortality. Although cell-derived hyaluronidases (HYALs) have been collectivel...

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Piezo1 is a mechanically activated cation channel whose N-linked glycans support protein maturation and plasma membrane trafficking, but their contribution to mechanical gating is unknown. We asked wh...

Vocal fold scarring (VFS) is a debilitating fibrotic disorder lacking molecular biomarkers for early detection or for monitoring toxicant-induced injury. Cigarette smoke toxicity (CST), a major enviro...

Hyaluronic acid (HA), a natural polysaccharide polymer, can positively regulate pear tree growth. In this study, exogenous HA was applied to fruiting-stage ’Xin

Journal of Perinatology - Temporal changes in hyaluronan concentrations in preterm human milk

Sarcopenia in alcohol-related liver disease (ALD) is of high clinical significance, but there are no effective treatments. Hyaluronan 35 kDa (HA35), a glycosaminoglycan polymer, modulates responses to...

Perineuronal nets (PNNs) are widely reported to close developmental critical periods and restrict experience-dependent plasticity. Here we tested this model by selectively eliminating gene expression ...

Aging is characterized by a progressive decline in cellular and tissue function, shaped in part by disruptions in communication between the extracellular matrix (ECM) and intracellular signaling netwo...

Primary sclerosing cholangitis (PSC) is a rare, progressive liver disease characterized by biliary inflammation and bile duct strictures and no approved medical therapy. Despite its clinical severity,...

Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid-β-(1-3)-N-acetylglucosamine polymerized by β(1-4) bonds, with no obvious active site for biological activity...