Doksani Lab @doksanilab.bsky.social · 21/05/2026www.cell.com/molecular-ce...cell.comDamage-induced i-loops generate eccDNA from repetitive elementsZanella et al. reveal a mechanism of eccDNA formation. Nicks or gaps at repetitive sequences promote i-loop formation that can be excised as eccDNA. Given the abundance of repetitive elements and the ... 000
Doksani Lab @doksanilab.bsky.social · 21/05/2026Thrilled to see our work featured on the cover of Molecular Cell. The image is an electron micrograph of an i-loop, the DNA structure we propose as a source of eccDNA formation. Almost like catching circular DNA formation in the act. #eccDNA #CancerResearch #GenomeInstability #DNARepair 141
Doksani Lab @doksanilab.bsky.social · 30/04/2026Huge congratulations to @ezeta.bsky.social for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM Facility for his contribution to the structural analysis authors.elsevier.com/a/1n0wG3vVUP...authors.elsevier.comPlease wait whilst we redirect youAll content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. 020
Doksani Lab @doksanilab.bsky.social · 30/04/2026How do cancer-associated eccDNAs arise? Our work shows that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer. 1/2 165
Doksani Lab @doksanilab.bsky.social · 09/04/2026Aiutateci a fare la differenza: sostenete la ricerca e correte con noi. #Maratona #AIRC #Ricerca #Oncologica www.retedeldono.it/iniziativa/y...retedeldono.itGYFT-4-CancerResearch | Rete del DonoSiamo Tiziana, Francesco, Gioacchino e Ylli, quattro ricercatori di IFOM, IEO e IIT.Con il team GYFT-4-CancerResearch partecipiamo alla staffetta della maratona di Milano... 000
Reposted by Doksani LabZha Lab @zhalab.bsky.social · 11/03/2026This week Dr. Doksani will join Social DNAing to discuss telomere biology! Please note the US is now in summer saving time. Check you local time! www.cancer.columbia.edu/research/pro... 052
Reposted by Doksani LabGIIN @genomeiinetwork.bsky.social · 29/01/2026Another great science appointment is coming up with @nitikataneja.bsky.social and @doksanilab.bsky.social! Join us live on Tuesday, February 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F... 064
Doksani Lab @doksanilab.bsky.social · 20/03/2025Telomere Community 🧬 Can't wait for the new CSHL Monograph? Our review on unusual structure at Telomeric repeats is now live on Cold Spring Harbor Perspectives! Grab a few free PDFs here: cshperspectives.cshlp.org/cgi/reprint/... #CHSL #AcademicSky #Science @ezeta.bsky.social @cshlnews.bsky.social 1113
