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Dmitriy

@dmitriy.bsky.social
757 followers 778 following 275 posts

Researcher at the Institute for Clinical and Economic Review (ICER), an independent nonprofit that analyzes the cost-effectiveness of drugs Creator of Demography feed: tinyurl.com/bskydemo

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Dmitriy @dmitriy.bsky.social · 03/09/2025
🧪Cytisinicline reduces symptoms of nicotine craving and withdrawal. If approved in June 2026, it will be the first new approved pharmacotherapy for smoking cessation in 20 years.
psychiatrictimes.com
FDA Accepts New Drug Application for Cytisinicline for Smoking Cessation
Achieve Life Sciences gains FDA acceptance for cytisinicline, a promising new drug for smoking cessation, showing significant abstinence rates in trials.
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Dmitriy @dmitriy.bsky.social · 04/08/2025
🧪Once a Death Sentence, This Heart Condition Is Finally Treatable A quiet revolution in care is helping patients with cardiac amyloidosis, a form of heart failure that long stumped doctors. www.nytimes.com/2025/08/04/w...
nytimes.com
Once a Death Sentence, This Heart Condition Is Finally Treatable
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Dmitriy @dmitriy.bsky.social · 02/04/2025
Some uplifting 🧪news from the latest Cure SMA annual report: The mortality rate of SMA in 2024 has dropped nearly 80% since 2014. Why? Newborn screening = earlier treatment & 3 FDA-approved therapies. ICER is currently reviewing a fourth therapy: icer.org/assessment/s...
Figure showing that the mortality rate of SMA in 2024 has dropped nearly 80% since 2014, having decreased from 1.84 per 100 individuals to 0.42 per 100 individuals with SMA.
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Dan Ollendorf @dano-hta.bsky.social · 22/01/2025
So pleased to be able to join Mike DiStefano and Wija Oortwijn to discuss #HTA activities in the context of serious affordability challenges. You should join us too!
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Dmitriy @dmitriy.bsky.social · 06/01/2025
🧪This morning, ICER announces a new review of 4 spinal muscular atrophy (SMA) therapies. With widespread US newborn screening & improved patient longevity, we're eager to assess progress in this rapidly advancing field since our 2019 report. #healthpolicy Draft scope below: icer.org/wp-content/u...
icer.org
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PharmacyChecker @pharmacychecker.bsky.social · 12/12/2024
The Institute for Clinical and Economic Review has identified 5 drugs with price increases not supported by new clinical evidence: Biktarvy Darzalex Entresto Cabometyx Xeljanz www.managedhealthcareexecutive.com/view/icer-id...
managedhealthcareexecutive.com
ICER Identifies 5 Drugs with Unsupported Price Increases
The Institute for Clinical and Economic Review has identified five drugs — Biktarvy, Darzalex, Entresto, Cabometyx, and Xeljanz — with prices increases that are not supported by new clinical evidence,...
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Dmitriy @dmitriy.bsky.social · 23/11/2024
🧪 Less than a month after four towering dams on the Klamath River were demolished, hundreds of salmon made it into waters they have been cut off from for decades to spawn in cool creeks
buff.ly
Salmon return to lay eggs in historic habitat after largest dam removal project in US history
Less than a month after four towering dams on the Klamath River were demolished, hundreds of salmon made it into waters they have been cut off from for decades to spawn in cool creeks.
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Dmitriy @dmitriy.bsky.social · 23/11/2024
🧪A second drug for transthyretin amyloid cardiomyopathy just got approved a week early. At $225K/year, it's more accessible than Pfizer's $268K Vyndaqel but still far exceeds ICER's recommended $13.6K-$39K range. Big news for the 50,000+ patients in US, but pricing debate continues.
statnews.com
BridgeBio wins FDA approval for heart disease drug
The FDA approved a new medicine from BridgeBio for patients with ATTR-CM, a progressive heart disease
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Dmitriy @dmitriy.bsky.social · 21/11/2024
🧪A survey of 879 U.S. healthcare professionals found: Popular media (69.5%psilocybin, 61.8% MDMA) and academic literature (65.6%, 47.9%) were respondents’ main current sources of knowledge Only 5.5% answered all 3 knowledge check questions correctly for psilocybin compared to just 1.1% for MDMA.
nature.com
Knowledge, attitudes, and concerns about psilocybin and MDMA as novel therapies among U.S. healthcare professionals - Scientific Reports
Scientific Reports - Knowledge, attitudes, and concerns about psilocybin and MDMA as novel therapies among U.S. healthcare professionals
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Dmitriy @dmitriy.bsky.social · 20/11/2024
🧪 People with MS often stop taking disease-modifying therapy as they transition from relapsing-remitting MS to secondary progressive MS. This study shows that people who stop stop therapy have higher hospitalization rates and more visits to the emergency room.
buff.ly
The Takeaway From Study of Midlife MS Patients: Don't Stop Disease-Modifying Therapy
People with multiple sclerosis (MS) often stop taking disease-modifying therapy as they transition from relapsing-remitting MS to secondary progressive MS. This study shows that people who stop stop…
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Dmitriy @dmitriy.bsky.social · 20/11/2024
🧪Today is the 20 year anniversary of Google Scholar! To celebrate the occasion, its two founders put together some fun facts related to the tool. blog.google/outreach-ini...
blog.google
20 things you didn’t know about Google Scholar
Google Scholar celebrates two decades of breaking down barriers to academic research and making it accessible to everyone, everywhere.
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Dmitriy @dmitriy.bsky.social · 20/11/2024
🧪 Experts found the Texas DFW area to be the third most dangerous for migrating birds. To help, the Lights Out team convinced downtown businesses to dim their lights, reducing confusion for birds. By Oct. 31, bird deaths dropped to 42, down from 110 last fall.
buff.ly
This city's businesses 'went dark' to reduce bird deaths — and it worked
A hotspot for bird migration, this region has now found success in reducing avian deaths, simply by turning off the lights.
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Dmitriy @dmitriy.bsky.social · 19/11/2024
🧪In 1980, Mount St. Helens erupted in Washington, destroying everything nearby. Gophers helped restore the soil by spreading microbes. Their digging resulted in 40,000 new plants in six years, leading to a thriving forest today.
buff.ly
Gophers were given one day to revive Mount St. Helens — and their impact on its ecosystem has lasted decades
By unearthing microbes and fungi, these rodents helped save an ecosystem almost decimated by the eruption of Mount St. Helens.
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Dmitriy @dmitriy.bsky.social · 18/11/2024
🧪 Washington state's voters upheld the Climate Commitment Act, a cap-and-trade law, by rejecting a repeal. This law has raised over $2 billion for clean transportation, clean energy, and climate adaptation efforts, with 62% voting to maintain it.
buff.ly
An attempt to repeal Washington's landmark climate law failed massively
"Every state legislator can now look to Washington and say, ‘This is a winning issue,’” Governor Jay Inslee told Grist.
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Dmitriy @dmitriy.bsky.social · 17/11/2024
🧪 Breakthrough brings hope: 3 patients who were losing their sight can see again, thanks to innovative stem cell transplants. Vision improvements lasted over a year, with no severe side effects.
buff.ly
World-first stem-cell treatment restores vision in people
The treatment, given to four people with damaged corneas, seems safe but needs to be tested in larger trials.
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Dmitriy @dmitriy.bsky.social · 17/11/2024
🧪Now that the Twitter exodus is in full force, I thought I'd create a curated list of researchers, journalists, and organizations working to strengthen scientific integrity and expose misconduct. Please reach out for any additions/removals from the pack! go.bsky.app/LC81roH
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Dmitriy @dmitriy.bsky.social · 16/11/2024
🧪 Rwanda contained Marburg outbreak with 22.7% fatality - far lower than typical 90%. Key: high-quality healthcare, rapid tracing/testing, experimental treatments, infection control. Rwanda also increased life expectancy by 20 years, from 47.5 in 2000 to 67.5 in 2021.
buff.ly
An 'unprecedented' good news story about a deadly viral outbreak
The death rate for Marburg virus can be as high as 90%. There are no approved vaccines and treatments. So how did Rwanda achieve what one doctor calls an "unprecedented" success in controlling its…
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Dmitriy @dmitriy.bsky.social · 15/11/2024
🧪 Millets are making a comeback in India after declining in the 1960s. They are drought-resistant, nutritious, and help reduce emissions and water use compared to other crops. The Indian gov is promoting cultivation/consumption to address climate change and food security.
buff.ly
Millets Are Making a Comeback in India
These hardy, drought-resistant and nutritious grains disappeared from fields in the 1960s. Now, the country is working to revive them.
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Dmitriy @dmitriy.bsky.social · 15/11/2024
🧪Female doctors had 2-3x higher survival rates for heart patients vs male docs. Up to 32K lives could be saved if male docs learned to treat women better. Cardiologist Marianne Legato and patient advocate Carolyn Thomas are working to fix this disparity. buff.ly/4g7FVm3
reasonstobecheerful.world
The Slow, Powerful Work of Bridging the Women's Health Gap
Women are still underrepresented in medical research. But thanks to trailblazers like cardiologist Marianne Legato and patient advocate Carolyn Thomas, that's starting to change.
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Dmitriy @dmitriy.bsky.social · 10/11/2024
🧪Antonia, a cloned black-footed ferret at the Smithsonian’s National Zoo and Conservation Biology Institute, has produced two healthy offspring that will help build genetic diversity in their recovering population www.smithsonianmag.com/smart-news/a...
smithsonianmag.com
A Cloned Ferret Has Given Birth for the First Time in History, Marking a Win for Her Endangered Species
Antonia, a cloned black-footed ferret at the Smithsonian's National Zoo and Conservation Biology Institute, has produced two healthy offspring that will help build genetic diversity in their recoverin...
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Dmitriy @dmitriy.bsky.social · 06/10/2024
The Eviction Lab at Princeton is seeking a Postdoctoral Research Assistant. Apply here: puwebp.princeton.edu/AcadHire/app... #AcademicSky🧪
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Dmitriy @dmitriy.bsky.social · 27/09/2024
🧪A new drug for schizophrenia was approved today! KarXT was reviewed by ICER earlier this year: icer.org/wp-content/u...
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The Washington Post @washingtonpost.com · 05/09/2024
A new study adds to a growing body of evidence that Parkinson’s disease, long believed to have its origins in the brain, may begin in the gut.
washingtonpost.com
Parkinson’s may begin in the gut, study says, adding to growing evidence
Mucosal damage — an erosion, break or sore in the mucous lining of the GI tract — was associated with a 76 percent greater risk of developing Parkinson’s.
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Dmitriy @dmitriy.bsky.social · 02/05/2024
🧪Congressional leaders unveil $275M bipartisan bill to boost menopause research, training & awareness. Led by Sen. Patty Murray & backed by Halle Berry, the bill funds NIH grants, public campaign, clinician training & diagnosis/treatment for midlife women's health issues.
washingtonpost.com
Senators, Halle Berry unveil $275 million bill to boost menopause care
Many physicians say they receive little training about menopause, which all women experience around mid-life.
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Dmitriy @dmitriy.bsky.social · 26/04/2024
🧪New dual-insecticide nets deployed through The Global Fund project prevented an estimated 13 million malaria cases and 24,600 deaths in sub-Saharan Africa by addressing growing mosquito resistance. 56 million next-gen nets reached people in 17 countries.
theglobalfund.org
New Nets Prevent 13 Million Malaria Cases in Sub-Saharan Africa
The New Nets Project, an initiative funded by Unitaid and the Global Fund and led by the Innovative Vector Control Consortium (IVCC), piloted the use of dual-insecticide in malaria-endemic countries b...
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Dmitriy @dmitriy.bsky.social · 26/04/2024
🧪Médecins Sans Frontières has released details of their spending on a major clinical trial for a drug-resistant TB treatment, and they are calling for greater transparency in clinical trial costs to expose the true costs of medical innovation.
theguardian.com
Cost of developing new drugs may be far lower than industry claims, trial reveals
Exclusive: MSF calls for transparency after its bill for a trial of TB treatment came to a fraction of the billions claimed by pharmaceutical companies
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Dmitriy @dmitriy.bsky.social · 22/04/2024
🧪Indigenous territories tend to have lower deforestation rates and higher forest regrowth when indigenous peoples have secure land rights. Research shows forests are often healthier under indigenous stewardship.
theverge.com
Want to restore a forest? Give it back to Indigenous peoples who call it home
These women are fighting to take back their land.
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Dmitriy @dmitriy.bsky.social · 06/04/2024
🧪NIST researchers developed a technique using a smartphone compass to measure tiny concentrations of biomarkers like glucose, enabling potential at-home diagnosis of diseases and detection of environmental toxins through low-cost magnetized hydrogels.
nist.gov
NIST Researchers Use Cellphone Compass to Measure Tiny Concentrations of Compounds Important for Human Health
Nearly every modern cellphone has a built-in compass, or magnetometer, that detects the direction of Earth’s magnetic field, providing critical information f
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Dmitriy @dmitriy.bsky.social · 06/04/2024
🧪The Gates Foundation will require grant holders to publish research as preprints from 2024. It will also stop paying article-processing charges, moving away from the open access model where publishers charge fees to make articles freely available online.
nature.com
Will the Gates Foundation’s preprint-centric policy help open access?
Revised policy says grant recipients must share manuscripts as preprints — and removes support for article-processing charges. Revised policy says grant recipients must share manuscripts as preprints ...
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Dmitriy @dmitriy.bsky.social · 04/04/2024
🧪Amylyx Pharma to withdraw its only ALS drug Relyvrio from US/Canada markets after late-stage trial fails to confirm earlier reported benefit. Company also cutting 70% of workforce and advancing other pipeline programs. #ALS #biopharma
reuters.com
Amylyx Pharma to remove ALS drug from US, Canada markets
Amylyx Pharmaceuticals will withdraw its amyotrophic lateral sclerosis (ALS) drug - its only product in the market - from the U.S. and Canada after the treatment failed in a key late-stage trial.
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Dmitriy @dmitriy.bsky.social · 04/04/2024
🧪Composting allows bodies to naturally decompose into soil, accelerating nutrient cycling by harnessing microbial heat to safely breakdown tissues in just 30-40 days, mitigating emissions from traditional funerary methods and saving more than a metric ton of carbon compared to alternatives.
npr.org
The ultimate green burial? Human composting lets you replenish the earth after death
Only seven states have legalized human composting as a burial practice. That's why 29 percent of the bodies brought to Recompose, a composting facility in Seattle, come from out of state.
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Dmitriy @dmitriy.bsky.social · 02/04/2024
🧪In 2023, the U.S. organ donation and transplant community continued a record-breaking trend that started eleven years ago. 10,660 liver transplants were performed last year, more than ever recorded in a single year, and more than 10,000 for the first time ever.
unos.org
A decade of record increases in liver transplant - UNOS
10,660 liver transplants, the most ever in a year.
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Dmitriy @dmitriy.bsky.social · 31/03/2024
🧪One of the silver linings of the pandemic was that the restrictions eliminated the Yamagata lineage of type B influenza—a viral source of death and disease, especially among children. Scientists now say it might be possible to eliminate a second strain, leading to the end of influenza B worldwide.
bloomberg.com
As Covid Spread, a Strain of Flu Disappeared. Now Scientists Say a Second Could Go Too
Stay-at-home orders, border closures, mask-wearing and other measures aimed at stemming Covid-19’s spread led to the global disappearance of a notorious winter germ. Now, scientists say it might be fe...
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Dmitriy @dmitriy.bsky.social · 08/03/2024
🧪Breast cancer mortality rate in US women fell 58% from 1975-2019 per JAMA study, with nearly half the reduction from earlier treatment of Stage 1-3 cancer and about 25% from improved mammography screening and 29% from better treatment of metastatic breast cancer.
washingtonpost.com
Breast cancer death rate dropped 58 percent over 44 years in U.S.
Despite the “overall progress in reducing breast cancer mortality, reductions have not been equally distributed across all patient populations,” a journal editorial noted.
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Dmitriy @dmitriy.bsky.social · 08/03/2024
🧪A child born with Cystic fibrosis in the ’50s could expect to live until age 5. In the early 2000s, age 35. With Trikafta, those who begin taking the drug in early adolescence, a recent study projected, can expect to survive to age 82.5—an essentially normal life span.
theatlantic.com
The Cystic-Fibrosis Breakthrough That Changed Everything
The disease once guaranteed an early death—but a new treatment has given many patients a chance to live decades longer than expected. What do they do now?
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Dmitriy @dmitriy.bsky.social · 05/03/2024
🧪The U.S. is failing to curb the opioid epidemic by not adequately expanding access to effective addiction medications like methadone and buprenorphine. They cut overdose deaths by 50-80%, yet due to barriers like stigma, only a small percentage of opioid addicted individuals receive them
statnews.com
How the U.S. is sabotaging its best tools to prevent deaths in the opioid epidemic
A yearlong STAT investigation shows that virtually every sector of American society is obstructing the use of medications that could prevent tens of thousands of overdose deaths.
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Dmitriy @dmitriy.bsky.social · 24/02/2024
🧪 A Pew survey found that only 57 per cent of Americans think science has had a “mostly positive effect on society,” down from 73 per cent in 2019. Now, more than ever, we need trustworthy science that is grounded in rigorous methods, and science communication that is balanced and accurate.
hilltimes.com
Needed: less science hype!
Now, more than ever, we need trustworthy science that is grounded in rigorous methods, and science communication that is balanced and accurate.
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Dmitriy @dmitriy.bsky.social · 20/02/2024
🧪A new NIH study found reducing lead levels in American Indian adults lowered blood pressure by up to 7 mm Hg, equivalent to the effect of blood pressure drugs.
nih.gov
Reduced blood lead levels linked to lower blood pressure in American
Reductions correlated with long-term cardiovascular health improvements in NIH-funded study.
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Dmitriy @dmitriy.bsky.social · 16/02/2024
🧪The CDC reported a 69% increase in Lyme disease cases in the US in 2022 compared to previous years. However, this increase is likely due to a change in how Lyme disease surveillance is conducted, not an actual explosion in cases.
statnews.com
Lyme disease cases rise, but largely due to a change in data collection
A new CDC report shows Lyme disease cases rose by 69% in 2022 over previous years. It's likely due to a new way of doing surveillance.
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Dmitriy @dmitriy.bsky.social · 15/02/2024
🧪Endometriosis affects around 1 in 10 women during their lifetime. It has been an overlooked disorder plagued by lack of awareness and research funding. A clinical trial of the first non-hormonal, non-surgical treatment for endometriosis, started in 2023 in Scotland, is showing promising results.
web.archive.org
The first endometriosis drug in four decades is on the horizon
At last, progress is being made on a condition that affects one woman in ten
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Dmitriy @dmitriy.bsky.social · 15/02/2024
🧪The American Heart Association just released its new report showing that the country has cut heart disease death rates by 70% since 1950 and stroke death rates by nearly a third since 1998.
ahajournals.org
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
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Dmitriy @dmitriy.bsky.social · 15/02/2024
🧪Microbes that rapidly convert CO2 to rock could lock away the greenhouse gas in deep underground storage sites, such as depleted oil and gas reservoirs
newscientist.com
Bacteria could help turn CO2 to rock under extreme conditions
Microbes that rapidly convert CO2 to rock could lock away the greenhouse gas in deep underground storage sites, such as depleted oil and gas reservoirs
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Dmitriy @dmitriy.bsky.social · 06/02/2024
🧪Scientists have developed a way to recycle single-use plastics using enzymes found in laundry detergents. The chemical recycling process can break down the plastic within 24 hours (84 times faster than industrial methods) and even allows for the production of high-quality reusable materials.
phys.org
An enzyme used in laundry detergent can recycle single-use plastics within 24 hours
Scientists at King's College London have developed an innovative solution for recycling single-use bioplastics commonly used in disposable items such as coffee cups and food containers.
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Dmitriy @dmitriy.bsky.social · 06/02/2024
🧪The New Zealand Environmental Protection Agency (EPA) will ban the use of per- and polyfluoroalkyl substances (PFAS) in cosmetic products starting in 2027. This will make the country one of the first in the world to take this step on PFAS to protect people and the environment.
chemistryworld.com
New Zealand set to be first country to ban PFAS in cosmetic products
Environment agency says it is taking a 'precautionary approach' to PFAS in nail polish, shaving cream, foundation, lipstick and mascara
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Dmitriy @dmitriy.bsky.social · 05/02/2024
🧪While ketamine clinics have proliferated as a rapid treatment for depression, dosing protocols & safety measures vary widely between the 500-750 US clinics as this off-label use faces little regulation. www.npr.org/sections/hea...
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Dmitriy @dmitriy.bsky.social · 02/02/2024
🧪The American Ornithological Society plans to change the names of all American birds named after people, affecting between 70 and 80 species predominantly found in the U.S. and Canada.
slate.com
American Birds Are Getting New Names. Now Comes the Hard Part.
Birds like the Cooper’s Hawk, Wilson’s Snipe, and Lincoln’s Sparrow are up for renaming.
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Dmitriy @dmitriy.bsky.social · 02/02/2024
🧪Loyal has launched a large clinical trial of over 1,000 dogs to test if its daily pill drug LOY-002 can extend healthy aging by delaying diseases. The 4-year study involves 50+ vet clinics and aims to prove metabolism targeting improves quality of life for senior dogs aged 10+.
longevity.technology
Loyal launches pivotal dog lifespan extension trial
First dog dosed in clinical study designed to demonstrate healthspan and lifespan extension in 1,000 senior dogs
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Dmitriy @dmitriy.bsky.social · 02/02/2024
🧪Nicole Shanahan has donated $100M to fund research slowing ovarian aging. She established research centers to study topics like how genes, metabolism & the brain impact ovarian aging over time. The goal is to help women have more fertility & career control.
ft.com
Ovaries are an enigma that could unlock human lifespan
Philanthropist Nicole Shanahan is spending $100mn to find answers to fundamental questions about ovaries
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Dmitriy @dmitriy.bsky.social · 02/02/2024
🧪600,000 people in the United States die suddenly each year. Genetic autopsies help uncover the mystery of sudden deaths in 30% of cases by detecting mutations that can cause hereditary heart conditions and arrhythmias, potentially preventing future deaths in at-risk families.
english.elpais.com
Genetic autopsies to unravel the mystery of sudden deaths
Post-mortem molecular analysis can reveal hereditary cardiac pathologies that explain a sudden death without apparent cause and help prevent others
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Dmitriy @dmitriy.bsky.social · 29/01/2024
🧪 A new report from the WHO indicates that 150 countries are reducing tobacco use, around 1 in 5 adults worldwide now consume tobacco compared to 1 in 3 in 2000, and there are 19 million fewer smokers than there were just two years ago.
paho.org
Tobacco use declines despite tobacco industry efforts to jeopardize progress
Geneva, 16 January 2024 — Globally there are 1.25 billion adult tobacco users, according to the latest estimates in the World Health Organization (WHO) tobacco trends report out today. Trends in 202...
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