Reposted by Dino LuethiAlex Kwan @alexkwan.bsky.social · 08/09/2026A great day at Basel catching up with the neuropharmacologists🇨🇭 @drfriid.bsky.social @dinoluethi.bsky.social 161
Dino Luethi @dinoluethi.bsky.social · 05/11/202550 years ago, Alexander Shulgin showed that 4-alkylated 2,5-dimethoxyamphetamines peak in potency with 2–3 carbon chains. We suggest longer chains reduce psychedelic-like effects mainly due to poor brain penetration, not reduced receptor activity. doi.org/10.1038/s413... #psychedelicsdoi.orgThe 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects - Molecular PsychiatryMolecular Psychiatry - The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects 030
Dino Luethi @dinoluethi.bsky.social · 01/03/2025A recent study suggests that no dose adjustment of #LSD is necessary in the presence of an SSRI that inhibits CYP2D6. #psychedelics ascpt.onlinelibrary.wiley.com/doi/10.1002/...ascpt.onlinelibrary.wiley.comAcute Effects and Pharmacokinetics of LSD after Paroxetine or Placebo Pre‐Administration in a Randomized, Double‐Blind, Cross‐Over Phase I TrialPsychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive and anxiety disorders, for which concomitant treatment with selective ser... 031
Dino Luethi @dinoluethi.bsky.social · 19/12/2024Acute dose-dependent effects and self-guided titration of continuous #DMT infusions. www.nature.com/articles/s41...nature.comAcute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants - NeuropsychopharmacologyNeuropsychopharmacology - Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants 051
Dino Luethi @dinoluethi.bsky.social · 17/11/2024Nice to meet you all here! 1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics 2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies 3) Arrested Development is my favorite TV show—I should watch it once again soon 1110
Reposted by Dino LuethiRich Haridy @richharidy.bsky.social · 12/11/2024Here is a starter pack I put together featuring all the psychedelic science researchers and journalists I could find on here. Let me know who I'm missing. It'd be great to get the conversation going on this platform go.bsky.app/NPvFX41 21509
Reposted by Dino LuethiGrant Glatfelter @gcglatfelter.bsky.social · 08/01/2024Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎. Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below: pubs.acs.org/doi/10.1021/... 051
Dino Luethi @dinoluethi.bsky.social · 17/11/2023Very nice early Christmas gift from our research group. Some insights into Albert Hofmann's work at Sandoz from the Novartis archives. A very nice read while waiting for the mass spec to measure our latest LSD plasma samples. #psychedelics #neuroskyence 161