- Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis. A new letter reply, in press this week at Clinical Infectious Diseases (18 April 2026), from our long-time friends and colleagues Eric Senneville and Benjamin Lipsky — two of the most thoughtful voices in diabetic foot infection — is worth a careful read. It is their (likely final) rejoinder in an ongoing conversation sparked by Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis. - -

- The Diabetic Foot was the recent feature of an interview given to KNST Radio's Healthwise Program, hosted by the Tucson Osteopathic Medical Association. The Diabetic Foot was the recent feature of an interview given to KNST Radio's Healthwise Program, hosted by the Tucson Osteopathic Medical Association. The Diabetic Foot was the recent feature of an interview given to KNST Radio's Healthwise Program, hosted by the Tucson Osteopathic Medical Association. - -

- * Please note, the sender's email address has not been verified. Wounds effect at least 5-7 million people per annum in the USA according to the Agency for Healthcare Quality (AHRQ), costing at least $20 Billion. Click the following to access the sent link: * Please note, the sender's email address has not been verified. Wounds effect at least 5-7 million people per annum in the USA according to the Agency for Healthcare Quality (AHRQ), costing at least $20 Billion. Click the following to access the sent link: * Please note, the sender's email address has not been verified. Wounds effect at least 5-7 million people per annum in the USA according to the Agency for Healthcare Quality (AHRQ), costing at least $20 Billion. Click the following to access the sent link: - -

- Diabetic Foot - Health News Story - WSOC CharlotteThe link:http://www.wsoctv.com/health/18448223/detail.html?taf=char Diabetic Foot - Health News Story - WSOC CharlotteThe link:http://www.wsoctv.com/health/18448223/detail.html?taf=char Diabetic Foot - Health News Story - WSOC CharlotteThe link:http://www.wsoctv.com/health/18448223/detail.html?taf=char - -

- Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia - -

- http://insciences.org/article.php?article_id=1348Dosing activity like we dose a drugThe late Paul Brand, the now legendary medical director of theHansen's Disease center in Carville, Louisiana, was quoted as saying"a wound will heat up before it breaks down". He was, of course,correct in this assertion. This led many (including me) to assumesomething of a linear conceptual relationship between steps,inflammation, http://insciences.org/article.php?article_id=1348Dosing activity like we dose a drugThe late Paul Brand, the now legendary medical director of theHansen's Disease center in Carville, Louisiana, was quoted as saying"a wound will heat up before it breaks down". He was, of course,correct in this assertion. This led many (including me) to assumesomething of a linear conceptual relationship between steps,inflammation, http://insciences.org/article.php?article_id=1348Dosing activity like we dose a drugThe late Paul Brand, the now legendary medical director of theHansen's Disease center in Carville, Louisiana, was quoted as saying"a wound will heat up before it breaks down". He was, of course,correct in this assertion. This led many (including me) to assumesomething of a linear conceptual relationship between steps,inflammation, - -

- Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia - -

- A Stanford team demonstrates that a smartphone app measuring vibration perception thresholds can detect large-fiber sensory deficits in patients with diabetes — a potential advance for accessible, patient-operated neuropathy screening. We spend a lot of time in this space talking about the devices we strap on, implant in, and wrap around the diabetic foot. But what about the device already in your pocket? A team from Stanford — led by Rachel Adenekan from Mechanical Engineering, with collaborators in Neurology and Endocrinology — just published a A Stanford team demonstrates that a smartphone app measuring vibration perception thresholds can detect large-fiber sensory deficits in patients with diabetes — a potential advance for accessible, patient-operated neuropathy screening. - -

- //www.youtube.com/get_playerClinical care and research were featured in this news story about the diabetic foot, amputation prevention, the team approach, and SALSA. //www.youtube.com/get_playerClinical care and research were featured in this news story about the diabetic foot, amputation prevention, the team approach, and SALSA. //www.youtube.com/get_playerClinical care and research were featured in this news story about the diabetic foot, amputation prevention, the team approach, and SALSA. - -

- This series from the Guardian and BMJ reviews practical best practices for care of people with diabetes, including care of the feet.-------To see this story with its related links on the guardian.co.uk site, go to http://www.guardian.co.uk/lifeandstyle/besttreatments/diabetes-type-1-nerve-damage-in-diabetesNerve damage in diabetesWednesday January 7 2009BMJ GroupOver time, high levels of glucose (sugar) in your blood can stop your This series from the Guardian and BMJ reviews practical best practices for care of people with diabetes, including care of the feet.-------To see this story with its related links on the guardian.co.uk site, go to http://www.guardian.co.uk/lifeandstyle/besttreatments/diabetes-type-1-nerve-damage-in-diabetesNerve damage in diabetesWednesday January 7 2009BMJ GroupOver time, high levels of glucose (sugar) in your blood can stop your This series from the Guardian and BMJ reviews practical best practices for care of people with diabetes, including care of the feet.-------To see this story with its related links on the guardian.co.uk site, go to http://www.guardian.co.uk/lifeandstyle/besttreatments/diabetes-type-1-nerve-damage-in-diabetesNerve damage in diabetesWednesday January 7 2009BMJ GroupOver time, high levels of glucose (sugar) in your blood can stop your - -

- A new accelerometer-based study from Michigan and Oxford shows that moderate-to-vigorous physical activity is associated with significantly lower odds of diabetic peripheral neuropathy — with vigorous activity cutting the odds by 60%. We tell our patients to stay active. We tell them it matters. But how much activity, exactly? And what kind? A new study from our colleagues at Michigan and Oxford starts to put hard numbers behind the advice. Reynolds and colleagues published a cross-sectional analysis of 2,878 people with diabetes in the Journal of Neurology, A new accelerometer-based study from Michigan and Oxford shows that moderate-to-vigorous physical activity is associated with significantly lower odds of diabetic peripheral neuropathy — with vigorous activity cutting the odds by 60%. - -

- A new Cell paper shows nerve hyperinnervation suppresses skin regeneration -- and botulinum toxin A removes the brake. For diabetic foot ulcers, this could be the breakthrough we've been waiting 30 years for. I read a paper in Cell yesterday morning that stopped me mid-coffee. Before lunchtime I was texting a my buddy, Prof. Jon Russin, a neurosurgeon (now Chief in Vermont) about resurrecting a grant from a few years ago. The paper is from Ya-Chieh Hsu's lab at Harvard: Hyperinnervation Inhibits Organ-Level Regeneration in Mammalian Skin (Tam A new Cell paper shows nerve hyperinnervation suppresses skin regeneration -- and botulinum toxin A removes the brake. For diabetic foot ulcers, this could be the breakthrough we've been waiting 30 years for. - -

A new Cleveland Clinic Perspective gives dedicated inpatient podiatry a practical framework: dependable toe-and-flow coordination, timely decisions, and a safer bridge from hospital to home.

- Diabetes-related foot disease (DFD) affects an estimated 200 million people globally, surpassing the disease burden of conditions like stroke and breast cancer. In their comprehensive article, Best Practice Offloading Treatments for Diabetic Foot Ulcer Healing, Remission, and Better Plans for the Healing-Remission Transition (Seminars in Vascular Surgery, 2025), Dr. Peter Lazzarini and Dr. Jaap J. van Netten examine the current state Diabetes-related foot disease (DFD) affects an estimated 200 million people globally, surpassing the disease burden of conditions like stroke and breast cancer. In their comprehensive article, Best Practice Offloading Treatments for Diabetic Foot Ulcer Healing, Remission, and Better Plans for the Healing-Remission Transition (Seminars in Vascular Surgery, 2025), Dr. Peter Lazzarini and Dr. Jaap J. van Netten examine the current state Diabetes-related foot disease (DFD) affects an estimated 200 million people globally, surpassing the disease burden of conditions like stroke and breast cancer. In their comprehensive article, Best Practice Offloading Treatments for Diabetic Foot Ulcer Healing, Remission, and Better Plans for the Healing-Remission Transition (Seminars in Vascular Surgery, 2025), Dr. Peter Lazzarini and Dr. Jaap J. van Netten examine the current state - -

- Thanks to Jake Wood, gifted vascular surgeon/artist at University of North Carolina Thanks to Jake Wood, gifted vascular surgeon/artist at University of North Carolina Thanks to Jake Wood, gifted vascular surgeon/artist at University of North Carolina - -

- Team, we often talk about the "endgame" of limb salvage—the complex surgeries, the revascularization, the high-tech grafts. But the truth? The war against amputation is usually won or lost long before a patient ever sees a surgeon. It’s won in the primary care office. Our latest paper, just out in the Journal of Diabetes and Team, we often talk about the "endgame" of limb salvage—the complex surgeries, the revascularization, the high-tech grafts. But the truth? The war against amputation is usually won or lost long before a patient ever sees a surgeon. It’s won in the primary care office. Our latest paper, just out in the Journal of Diabetes and Team, we often talk about the "endgame" of limb salvage—the complex surgeries, the revascularization, the high-tech grafts. But the truth? The war against amputation is usually won or lost long before a patient ever sees a surgeon. It’s won in the primary care office. Our latest paper, just out in the Journal of Diabetes and - -

- Opportunities for diabetes and peripheral artery disease-related lower limb amputation prevention in an Appalachian state: A longitudinal analysis Great work from West Virginia's Sam Minc and coworkers with a little help from us here at USC. SamanthaDanielle MincabStevanBudicDylanThibaultaRanjitaMisradDavid GArmstrongeGordonStephen SmithfLukeMaronea Lower extremity amputation due to peripheral artery disease (PAD) and diabetes (DM) is a life-altering event that identifies disparities in Opportunities for diabetes and peripheral artery disease-related lower limb amputation prevention in an Appalachian state: A longitudinal analysis Great work from West Virginia's Sam Minc and coworkers with a little help from us here at USC. SamanthaDanielle MincabStevanBudicDylanThibaultaRanjitaMisradDavid GArmstrongeGordonStephen SmithfLukeMaronea Lower extremity amputation due to peripheral artery disease (PAD) and diabetes (DM) is a life-altering event that identifies disparities in Opportunities for diabetes and peripheral artery disease-related lower limb amputation prevention in an Appalachian state: A longitudinal analysis Great work from West Virginia's Sam Minc and coworkers with a little help from us here at USC. SamanthaDanielle MincabStevanBudicDylanThibaultaRanjitaMisradDavid GArmstrongeGordonStephen SmithfLukeMaronea Lower extremity amputation due to peripheral artery disease (PAD) and diabetes (DM) is a life-altering event that identifies disparities in - -