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Christophe Dessimoz

@dessimoz.bsky.social
732 followers 214 following 28 posts

Executive Director of SIB Swiss Institute of Bioinformatics @sib.swiss and Professor at the University of Lausanne (UNIL), Switzerland. @cdessimoz and @dessimoz@mstdn.science elsewhere. Comparative Genomics, Phylogenetics, Evolution, Computational Biology.

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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
And an EMBO meeting report led by Athina Gavriilidou entitled “Advances and challenges in understanding evolution through genome comparison.” doi.org/10.1093/bioa...
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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
Correspondence in Nature: to make FAIR a reality, fund the data resources and expertise—not just data-management plans. A call to action co-signed with @francesarnold.bsky.social, Rich Roberts, and Tim Hubbard. doi.org/10.1038/d415...
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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
Gene annotations matter for downstream analyses: different structural gene-annotation pipelines yield markedly different orthology calls. We compare four strategies across species and argue for standards & QC before inference. Work led by @silviaprietob.bsky.social. Paper: doi.org/10.1093/bioi...
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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
EdgeHOG reconstructs ancestral gene order at Tree-of-Life scale in linear time. 2,845 genomes → 1,133 ancestors. Vontigs for LECA (~1.8 Ga). Also dates gene adjacencies & rearrangements. Sexual chroms stand out! Led by Charles Bernard (research.pasteur.fr/fr/member/ch...) doi.org/10.1038/s415...
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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
Testing the "least-diverged ortholog” conjecture on >1M structs + expression across 16 animals & 20 plants, the LDO tends to retain ancestral function while the other copy specialises. Work led by @irenejulca.bsky.social. Paper: doi.org/10.1101/gr.2... Free preprint: www.biorxiv.org/content/10.1...
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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
Structure-informed phylogenetic inference with FoldTree outperforms sequence-only trees on divergent proteins, and untangles RRNPPA quorum-sensing receptors across Gram-positive bacteria & phages. Work led by David Moi (www.linkedin.com/in/david-moi) Paper: doi.org/10.1038/s415...
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Christophe Dessimoz @dessimoz.bsky.social · 24/07/2025
Really important points by @alexbateman1.bsky.social on the importance of curation, addressing some of the myths out there. Deeply resonates with the commentary Paul Thomas and I wrote last year www.nature.com/articles/s41...
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Christophe Dessimoz @dessimoz.bsky.social · 22/07/2025
Fantastic keynote by @marcrr.bsky.social at the joint EvolCompGen-Function session of #ISMBECCB2025 on the power of (curated & FAIR) gene expression data from @bgee.org to study functional retention and innovation across animals, summarising 15+ yrs of work Paper: www.unil.ch/dee/en/home/...
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Christophe Dessimoz @dessimoz.bsky.social · 22/05/2025
🧬 Pandemics. AI. Digital sovereignty. In life sciences, these are no longer separate topics – they are converging challenges that demand one thing above all: *trusted data infrastructure*. The new SIB Profile 2025 is out. Thread!
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Christophe Dessimoz @dessimoz.bsky.social · 04/03/2025
When the @sib.swiss Roadshow Initiative works out, everyone wins: optimized travel, more scientific exchange, and a chance to catch top speakers across Switzerland—this time with Prof. Piyanun Harnpicharnchai on fungal communities & water quality. @saramitri.bsky.social @cbank.bsky.social
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Christophe Dessimoz @dessimoz.bsky.social · 08/02/2025
SIB has stopped posting on X and joined BlueSky. Follow here @sib.swiss. We will continue posting on Mastodon mstdn.science/@SIB and LinkedIn too. Quite a few SIB colleagues are already on BlueSky. Follow them here: go.bsky.app/TcDfZrs
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Christophe Dessimoz @dessimoz.bsky.social · 09/12/2024
Our dear colleague @firefoxx66.bsky.social is indeed one to watch in 2025! 💯https://www.nature.com/immersive/d41586-024-03890-5/index.html
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