Cyclin-dependent kinase 9 (CDK9) inhibition represents a promising therapeutic strategy in cancers that disrupts RNA polymerase II pause release and collapses oncogenic transcripts. Here, we show that...

Uncovering the Immunogenic Landscape of Transposon-Driven Transcripts in Paediatric Acute Myeloid Leukaemia Primary supervisor: Özgen Deniz, Queen Mary University of London Secondary supervisor: Ri...

Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...

Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...

Join us in celebrating becoming an official Centre for Epigenetics at QMUL!

Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis

Join us in celebrating becoming an official Centre for Epigenetics at QMUL!

Abstract. LINE-1 (L1) is a parasitic retrotransposable DNA element, active in primates for the last 80–120 Myr. L1 has generated nearly one-third of the hu

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Karttunen et al. identify the contribution of transposable elements to gene regulatory function in colorectal and liver cancer cell lines.