iiinova — where your digital self keeps evolving

Decoding Longevity @decodinglongevity.bsky.social · 3h

What if your health could be understood through your own biology—not population averages? In Ep. 35, Raghav Sehgal & Macsue Jacques talk with Prof. Nathan Price of the Buck Institute about AI, digital twins & personalized health. Spotify open.spotify.com/episode/1pv6... YouTube youtu.be/qLfrqR5RFho

000

Decoding Longevity @decodinglongevity.bsky.social · 24/09/2026

Rapamycin is one of the most studied interventions in longevity research—but there are still plenty of misconceptions surrounding it. Our latest Facts & Myths breaks down 3 common claims about rapamycin, mTOR, biological aging, and healthspan.

100

Decoding Longevity @decodinglongevity.bsky.social · 16/09/2026

Can we actually slow biological aging? Episode 34 of Decoding Longevity is now live with Professor Matt Kaeberlein, in conversation with Dr. Raghav Sehgal and Dr. Macsue Jacques. We explore mTOR, rapamycin, the Dog Aging Project, TRIAD, Aura Biomedical, WormBot, and the future of longevity research

100

Decoding Longevity @decodinglongevity.bsky.social · 07/09/2026

What does a shingles vaccine have to do with dementia? Our latest Decoding Longevity episode with Dr. Moshe Shay Ben-Haim explores Shingrix, trained immunity, cognitive aging, and longevity. We’re breaking down 3 myths about the science. 🧬 Which one surprised you most? 🎙️ Episode 33 is live. 👇

111

Decoding Longevity @decodinglongevity.bsky.social · 04/09/2026

What if a vaccine designed to prevent shingles could also offer clues about dementia? In Episode 33 of Decoding Longevity, Dr. Moshe Shay Ben-Haim joins Dr. Raghav Sehgal & Dr. Macsue Jacques to explore Shingrix, immune resilience, cognitive preservation, and neurodegeneration. 🎙️ Episode 33 is live.

200

Decoding Longevity @decodinglongevity.bsky.social · 02/09/2026

Episode 33 of Decoding Longevity is live! Raghav Sehgal and Macsue Jacques are joined by Dr. Moshe Shay Ben-Haim, Senior Lecturer at the Hebrew University of Jerusalem, to explore Shingrix, dementia, cognitive preservation, trained immunity, and epigenetics. Thank you, Dr. Shay, for joining us! 🧬

100

Decoding Longevity @decodinglongevity.bsky.social · 26/08/2026

Could five proteins reveal how your immune system is aging? 🧬 David Furman of the Buck Institute joins Raghav Sehgal & Macsue Jacques to explore inflammatory aging, immune health & biomarkers on Decoding Longevity. Spotify: open.spotify.com/episode/6wJh... Youtube: youtu.be/i3iKyT9p2O4?... 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 24/08/2026

How old is your immune system, really? 🧬 Chronological age doesn’t tell the whole story. David Furman, joins Raghav Sehgal & Macsue Jacques on Decoding Longevity to explore immune aging, inflammation, and the biomarkers helping us understand how we age. Swipe through 3 myths 👇

200

Decoding Longevity @decodinglongevity.bsky.social · 13/08/2026

Biological age tells us where we are. But what if we also need to know where we're headed? The pace of aging looks at how rapidly our bodies are changing—a key idea from Raghav Sehgal, Macsue Jacques & Daniel W. Belsky. #Longevity

101

Decoding Longevity @decodinglongevity.bsky.social · 10/08/2026

An odometer tells you how far you've traveled. A speedometer tells you how fast you're going. What if aging works the same way? A key idea from Dr. Raghav Sehgal, Dr. Macsue Jacques, and Associate Professor Daniel W. Belsky. 👇 #Longevity

200

Decoding Longevity @decodinglongevity.bsky.social · 06/08/2026

Maybe we've been measuring aging the wrong way. The better question may not be "How old are you?" but "How fast are you aging?" A fascinating conversation between Dr. Raghav Sehgal, Dr. Macsue Jacques, and Associate Professor Daniel W. Belsky. #Longevity #HealthyAging

200

Decoding Longevity @decodinglongevity.bsky.social · 05/08/2026

🎙️ Episode 31 is now live! This week, Dr. Raghav Sehgal and Dr. Macsue Jacques welcome Associate Professor Daniel W. Belsky from the Columbia University Mailman School of Public Health for a fascinating conversation on the science of measuring the pace of aging.

100

Decoding Longevity @decodinglongevity.bsky.social · 31/07/2026

"People are diving in on rapamycin in the absence of almost any useful evidence." Professor Richard A. Miller (University of Michigan) discusses why evidence—not enthusiasm—should guide longevity interventions. Hear the full conversation with Raghav Sehgal and Dr. Macsue Jacques. #Longevity

100

Decoding Longevity @decodinglongevity.bsky.social · 30/07/2026

"The public thinks aging is immutable. They're wrong." Professor Richard A. Miller (University of Michigan) explains why this belief may be holding back progress in aging research. Hear the full conversation with Raghav Sehgal and Dr. Macsue Jacques in Episode 30 of Decoding Longevity. #Longevity

100

Decoding Longevity @decodinglongevity.bsky.social · 24/07/2026

"Healthspan is an awful term." Why would Professor Richard A. Miller (University of Michigan) say that? In Episode 30 of Decoding Longevity, Raghav Sehgal and Dr. Macsue Jacques explore why one of longevity science's most common terms deserves a closer look. #Longevity

100

Decoding Longevity @decodinglongevity.bsky.social · 22/07/2026

🎙️ New episode! Raghav Sehgal and Dr. Macsue Jacques talk with Professor Richard A. Miller (University of Michigan) about how scientists test whether longevity interventions really slow aging. From rapamycin to biomarkers and replication, it’s evidence over hype. Listen now! #Longevity

100

Decoding Longevity @decodinglongevity.bsky.social · 10/07/2026

What if the next frontier in HIV care isn't just helping people live longer—but helping them age healthier? Professor Linda-Gail Bekker discusses accelerated biological aging in people living with HIV and why protecting healthspan is just as important as extending lifespan. 👇

110

Decoding Longevity @decodinglongevity.bsky.social · 02/07/2026

What if longevity isn't measured by how long we live, but by how well we live? Professor Linda-Gail Bekker from the Desmond Tutu HIV Centre reminds us: “Longevity is more than just lifespan. It's about healthspan—helping people live longer, healthier lives.” 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 01/07/2026

After a short break, a new episode of Decoding Longevity is out 🎧

100

Decoding Longevity @decodinglongevity.bsky.social · 19/06/2026

What if some of the answers to neurodegeneration are hidden in hibernation? Hibernating mammals repeatedly develop and clear tau phosphorylation while rebuilding neuronal connections. A fascinating insight from Dr. Ashley Zehnder of Fauna Bio on Decoding #Longevity. #Neuroscience #Alzheimers 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 17/06/2026

What if evolution has already solved problems we're still trying to fix? A fascinating perspective from Dr. Ashley Zehnder of Fauna Bio on Decoding Longevity with Dr. Raghav Sehgal and Dr. Macsue Jacques. #Longevity #ComparativeBiology #FaunaBio

100

Decoding Longevity @decodinglongevity.bsky.social · 16/06/2026

What happens when sequencing becomes cheap enough to study nature's most extraordinary species at scale? According to Dr. Ashley Zehnder of Fauna Bio, we're entering a new era of comparative biology—one that could transform drug discovery and longevity science. #AshleyZehnder #FaunaBio 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 13/06/2026

Hibernation may be one of nature’s most powerful regenerative programs. How do hibernating mammals survive extreme physiological stress without fibrosis, muscle loss, or neurodegeneration? Dr. Ashley Zehnder of Fauna Bio explores the answer on Decoding Longevity. #Longevity #AshleyZehnder #FaunaBio

100

Decoding Longevity @decodinglongevity.bsky.social · 12/06/2026

What if the answers to aging aren't in humans—but in animals that have already solved these problems? In Episode 28 of Decoding Longevity, Dr. Ashley Zehnder (Co-Founder & CEO, Fauna Bio) joins hosts Dr. Raghav Sehgal and Dr. Macsue Jacques 👇

220

Decoding Longevity @decodinglongevity.bsky.social · 10/06/2026

What if evolution has already solved some of the biggest challenges in medicine? In Episode 28 of Decoding Longevity, Dr. Ashley Zehnder (Co-Founder & CEO, Fauna Bio) joins hosts Dr. Raghav Sehgal and Dr. Macsue Jacques to explore how 👇

110

Decoding Longevity @decodinglongevity.bsky.social · 06/06/2026

What if the most powerful longevity interventions are the ones we already know? In this clip from Decoding Longevity, Dr. Eric Verdin (@buckinstitute.org) explains why exercise, nutrition, sleep, stress management, and purpose remain essential for healthy aging.

210

Decoding Longevity @decodinglongevity.bsky.social · 01/06/2026

What if aging is partly driven by an immune system that never gets the signal to stand down? Dr. Eric Verdin on "inflammaging": "Inflammaging reflects what happens when a normally protective immune response becomes chronically activated." Hosted by Dr. Raghav Sehgal & Dr. Macsue Jacques.

100

Decoding Longevity @decodinglongevity.bsky.social · 28/05/2026

What if aging is not just decline — but a biologically regulated process? In our latest Decoding Longevity episode, Dr. Eric Verdin explains how metabolism, nutrient sensing, inflammation, NAD+, and epigenetics may shape how we age. 👇

230

Decoding Longevity @decodinglongevity.bsky.social · 27/05/2026

Our latest Decoding Longevity episode is now live. This week, we’re joined by Dr. Eric Verdin, President & CEO of the Buck Institute for Research on Aging, for a deep discussion on metabolism, immune aging, inflammation, epigenetics, and the future of longevity science.

231

Decoding Longevity @decodinglongevity.bsky.social · 22/05/2026

“The goal isn’t living forever. It’s reducing the years we spend unhealthy.” — Dr. Janine Sengstack Dr. Janine Sengstack joins Dr. Raghav Sehgal and Dr. Macsue Jacques on Episode 26 of Decoding Longevity to discuss RNA therapeutics, AI-driven biology, and the future of cell reset therapies.

110

Decoding Longevity @decodinglongevity.bsky.social · 20/05/2026

What if aging isn’t damage… but misregulation? Episode 26 of Decoding Longevity, hosted by Raghav Sehgal and Macsue Jacques, with Dr. Janine Sengstack. We explore “Cell Reset Therapeutics” — a shift from replacing cells to restoring their function.

100

Decoding Longevity @decodinglongevity.bsky.social · 18/05/2026

In Episode 26 of Decoding Longevity, Dr. Janine Sengstack explains how siRNA therapeutics could make “undruggable” transcription factors targetable. A fascinating conversation with Dr. Raghav Sehgal and Dr. Macsue Jacques on RNA medicine and longevity biotech.

110

Decoding Longevity @decodinglongevity.bsky.social · 08/05/2026

Why do humans treat aging and death as if they are inherently “good” or “necessary”? In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about how cultural and moral narratives shape longevity science. 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 04/05/2026

“Nature is ruthless.” In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about why the belief that “natural = good” may be limiting progress in longevity science. 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 01/05/2026

We’ve become very good at talking to ourselves in this field—but not at driving real progress. A sharp reflection on the state of longevity research. In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about the structural and cultural challenges slowing the field.

100

Decoding Longevity @decodinglongevity.bsky.social · 30/04/2026

What if the future of longevity is shaped not just by science—but by the stories we tell about aging? In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about the ethical and economic forces shaping aging research. 🎧 Listen Spotify: open.spotify.com/episode/2l9Y...

110

Decoding Longevity @decodinglongevity.bsky.social · 29/04/2026

A new episode of Decoding Longevity is now live. Raghav Sehgal and Macsue Jacques are joined by Dr. Raiany Romanni-Klein (AFAR) to explore how ethics, economics, and cultural narratives shape the future of aging science. Thank you, Raiany, for a thoughtful and important conversation.

110

Decoding Longevity @decodinglongevity.bsky.social · 21/04/2026

We’re not building a new model for aging. We’re using the same clinical model—on a new target. That target is aging itself. In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Michael Ringel about what this shift really means. 🎧 Listen: Spotify: open.spotify.com/episode/4Glm... 👇

100

Decoding Longevity @decodinglongevity.bsky.social · 17/04/2026

What if aging could be rewritten? Raghav Sehgal opens this episode with a powerful idea—followed by a deep dive with Macsue Jacques and Dr. Michael Ringel (Life Biosciences). From theory to human trials.

100

Decoding Longevity @decodinglongevity.bsky.social · 15/04/2026

🚨 What if aging isn’t something we just accept — but something we can reprogram? A new episode of Decoding Longevity is now live.

100

Decoding Longevity @decodinglongevity.bsky.social · 09/04/2026

You don’t “suddenly” get old. You gradually lose reserve—until something breaks. In this episode, Stephen Kritchevsky joins Raghav Sehgal and Macsue Jacques to explain how physiological reserve decreases over time, often unnoticed—until a fall, fracture, or loss of function occurs.

100

Decoding Longevity @decodinglongevity.bsky.social · 08/04/2026

What if aging is less about diseases—and more about declining function? In this episode, Stephen Kritchevsky joins Raghav Sehgal and Macsue Jacques to explore aging as a system-wide process. From mobility to metabolism, these declines shape how we live—not just how long.

100

Decoding Longevity @decodinglongevity.bsky.social · 07/04/2026

If we could slow aging… how would we know? Episode 23 of Decoding Longevity explores one of the biggest challenges in longevity science — measuring impact in humans. 🎧 Listen: Spotify → open.spotify.com/episode/2r1E... YouTube → youtu.be/kuxVfl_gKfE?... #agingresearch #healthspan

010

Decoding Longevity @decodinglongevity.bsky.social · 02/04/2026

What if aging is less about disease — and more about losing physiological reserve? In Episode 23 of Decoding Longevity, Stephen Kritchevsky shares how mobility, strength, and resilience shape how we age. #longevity #agingresearch #healthspan

320

Decoding Longevity @decodinglongevity.bsky.social · 01/04/2026

What if the most important question in aging isn’t “how long?” — but “how well?” In this episode of Decoding Longevity, Stephen Kritchevsky shares insights on mobility, metabolism, and what really shapes healthy aging. #longevity #agingresearch #healthspan

310

Decoding Longevity @decodinglongevity.bsky.social · 27/03/2026

Longevity breakthroughs don’t move at the speed of science — they move at the speed of policy. In Episode 22 of Decoding Longevity, Dylan Livingston explains why infrastructure and regulation shape real-world impact.

100

Decoding Longevity @decodinglongevity.bsky.social · 25/03/2026

90% of the diseases that kill us are driven by aging. Yet aging research receives less than 1% of funding. In this episode of Decoding Longevity, Dylan Livingston explores why this gap exists — and why it matters.

100

Decoding Longevity @decodinglongevity.bsky.social · 24/03/2026

Longevity breakthroughs don’t automatically translate into real-world impact. In this episode of Decoding Longevity, Dylan Livingston explores why infrastructure and policy may be just as important as science itself. Spotify → open.spotify.com/episode/2z0c... YouTube → youtu.be/ZAoMhgyn1Nc?...

000

Decoding Longevity @decodinglongevity.bsky.social · 12/03/2026

What if longevity science isn’t about stopping aging — but preventing disease? In this episode of Decoding Longevity, biotech entrepreneur James Peyer explains how preventative medicine could reshape how we think about aging

210

Decoding Longevity @decodinglongevity.bsky.social · 09/03/2026

“Aging is not a one-step path to medicine — it’s a long-term effort across many discoveries.” In Episode 21 of Decoding Longevity, James Peyer discusses why translating aging biology into real medicines requires many discoveries over time. With hosts Raghav Sehgal and Macsue Jacques.

100