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Drug Discovery Unit, University of Dundee

@ddu-dundee.bsky.social
371 followers 527 following 89 posts
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 17/09/2026
Molecules like these have the potential to fight #antibioticresistance by working as adjuvents - acting to restore the power of existing antibiotics. #DrugDiscovery
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 17/09/2026
Happy New Paper Day! We're excited to share this @natchembio.nature.com on #SmallMoleculeInhibitors of NorA, an efflux pump that is an important mediator of #antibioticresistance in #MRSA. It pumps antibiotics out , lowering their concentration in the cell. doi.org/10.1038/s415...
doi.org
Small-molecule inhibitors block NorA efflux by conformational trapping - Nature Chemical Biology
Multidrug efflux pumps expel antibiotics, contributing to antibiotic resistance. Now, high-throughput screening and structural characterization reveal an inhibitor of Staphylococcus aureus efflux pump...
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Reposted by Drug Discovery Unit, University of Dundee
Guðjón Ólafsson @godjohn.bsky.social · 15/07/2026
A fully funded PhD position is now open in my lab at the University of Iceland. We are looking for an ambitious researcher to join us in Reykjavik, Iceland to work on targeted protein degradation. Interested? You are welcome to contact me or check out: 🔗https://euraxess.ec.europa.eu/jobs/452601
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Reposted by Drug Discovery Unit, University of Dundee
Manu De Rycker @mdr-ddu.bsky.social · 01/06/2026
Our #Trypanosoma cruzi single-cell atlas paper is now available online! Great work by Ross Laidlaw and Marta Garcia Sanchez, and excellent collaboration with Thomas Otto! rdcu.be/flOWR @ddu-dundee.bsky.social, @dundeeuni.bsky.social #single-cell, #Chagas, #atlas, #trypanosome, #scRNA-seq 🧪🔬
rdcu.be
Trypanosoma cruzi cell atlas as a single-cell resource for understanding parasite population heterogeneity and differentiation
Nature Communications - Here, Laidlaw, Garcia Sanchez and colleagues present a single-cell atlas for Trypanosoma cruzi, an important protozoan pathogen, providing insights into cell heterogeneity,...
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 26/05/2026
Rabbitt highlights the #FemTech revolution & the surge of women investors who are finally putting their money where our health is, aggressively closing that research gap. #WomeninSTEM #WomensHealth #WomensHealthMonth #BookReview #DDUat20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 26/05/2026
The narrative doesn’t shy away from the frustrating reality that women’s health has been chronically underfunded & overlooked, leaving us decades behind in research & effective treatments. However, there’s a hopeful spark here... #MedicalSexism #HealthEquity
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 26/05/2026
By fully understanding what is happening to our bodies in the present, we can be better prepared for what lies ahead; this shifts the narrative from being reactive once a problem arises to being proactive with conditions like heart disease before they progress. #WomensHealth #HealthAwareness
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 26/05/2026
The book makes a compelling case for why your gynaecological history, such as #preeclampsia or #gestationaldiabetes, aren't just isolated events, but early warning signs for #cardiovascular health later in life. #WomensHealthMonth
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 26/05/2026
This book serves as a roadmap for navigating a system that has long ignored female-specific biology. Rabbitt dismantles the archaic notion that women should stoically endure debilitating symptoms like chronic period pain or severe hot flushes as "normal" life stages. #MedicalSexism #HealthEquity
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 26/05/2026
Hi sky-pals! We here at DDU towers hope you are keeping cool in these hot May days! Let's continue our #BookReviews as part of #WomensHealthMonth, give you something to read over your lunch break! Today we're reading Meghan Rabbitt’s The New Rules of Women’s Health #DDUat20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
By bridging the gap between data & lived experience, Perez proves that the medical field’s failure to collect sex-disaggregated data isn't just an oversight it is a life-threatening flaw. The book reveals a system that doesn't just ignore women, but fundamentally fails to understand them.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
Perez also discusses the #YentlSyndrome, where women’s pain is frequently dismissed as psychosomatic, leading to a staggering average of eight years to diagnose conditions like #endometriosis! #WomensHealthMonth #PillarsofWomensHealth
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
Women are 50% more likely to be misdiagnosed during heart attacks because their symptoms don't match the standard male chest pain. Drugs are often dosed based on male physiology, leading to higher #adversereaction rates in women. #HealthEquity #DrugDevelopment #MedicalSexism
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
It turns out, treating women like "men with extra hormones" is about as effective as using a map of Dundee to navigate New York! This bias has devastating consequences in both diagnosis of conditions (see our Pillars of women's health!) & development of treatments #InvisibleWomen #HealthEquity
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
In it, she reviews the gender data gap in healthcare, where the 70 kg Caucasian male serves as the universal default. Perez argues that by excluding women from clinical trials to avoid hormonal complexity, medicine treats the female body as an atypical version of man. #MedicalSexism
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
Happy Friday y'all! Hope you all had a good week. We've got some more #BookReviews for you for #WomensHealthMonth. This morning we are talking about "Invisible Women - Exposing data bias in a world designed for men" by @ccriadoperez.bsky.social #DDUat20 #HealthEquity #WomenInSTEM #InvisibleWomen
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
Ultimately, the birth of gynaecology depended entirely on the intellectual and physical endurance of Black women. Their uncredited labour remains the invisible bedrock of modern reproductive medicine. #BlackInSTEM #FeministHistory #HealthEquity
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
However, their contribution extended far beyond being passive subjects. Lacking professional staff, these women were forced to act as skilled surgical assistants. This #MedicalBondage created a system where were they were both subjects & staff. #MedicalEthics
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
J. Marion Sims, hailed as the father of #gynaecology, used enslaved women for experimental surgeries, providing essential clinical data to cure conditions which had previously rendered many enslaved women "unproductive" in both labour and childbearing. #BlackWomen #MedicalEthics
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
Following the 1808 transatlantic slave trade ban, slaveholders relied on reproduction to maintain the enslaved population. Reproductive health became a matter of intense economic concern, incentivising doctors to specialise in repairing reproductive injuries. #History #Bioethics
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
Deirdre Cooper Owens’ book Medical Bondage redefines the history of American gynaecology. By centring enslaved Black women, she reveals them not just as victims, but as foundational contributors to the medical field. #BlackHistory #MedicalHistory #WomensHealthMonth
Book cover: Medical Bondage. Race, Gender and the Origins of American Gynecology by Deirdre Cooper Owens
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
Morning skypals! Tea-break time seems like a good time for a book review - how about it? We will start with Medical Bondage, by Deirdre Cooper Owens, an American historian & reproductive rights activist #womenshealthmonth #DDUat20 #BookReview
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 18/05/2026
NHS urged to update website after renaming polycystic ovary syndrome (as polyendocrine metabolic syndrome (PMOS) - missing from the headline) #womenshealthmonth #DDUat20 #PMOS www.theguardian.com/society/2026...
theguardian.com
NHS urged to update website after renaming polycystic ovary syndrome
Charity says absence of new name polyendocrine metabolic syndrome (PMOS) could cause confusion
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Reposted by Drug Discovery Unit, University of Dundee
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 18/05/2026
Mycobacteriophage TM4 requires XylR for successful infection in Mycobacterium smegmatis mc2155 www.biorxiv.org/content/10.64898/20…
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 18/05/2026
#POIDH Ahem.....
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 18/05/2026
Good morning skypals! We hope you all have a relaxing weekend and are looking forward to a great week! This week we have some excellent book reviews to share for #WomensHealthMonth What have you got coming up?
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Chemistry World @chemistryworld.com · 14/05/2026
The difference between isoleucine and valine is not that great, which made isoleucine the ideal target for substitution, but simply replacing isoleucine with valine didn’t work as well as hoped. Read on: www.chemistryworld.com/news/strippe...
chemistryworld.com
Stripped down bacterium functions with one less amino acid than the rest of life on Earth
Deep learning models used to understand how isoleucine could be replaced in proteins without disrupting their structures
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 13/05/2026
....is the #GTA in the room with you...
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 13/05/2026
Got a science shaped hole in your Monday evening? Why not pop along to #PintofScience! Rosie Street-Jeakings & Christopher Bailey are both talking about #malaria research. Get your tickets at the link! pintofscience.co.uk/event/drugs-...
pintofscience.co.uk
Drugs and Bugs: The Fight for Global Health
Why does disease only target certain people? How do we make new treatments for that disease? Does your postcode alter the treatment you get? These are all …
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
We reposted this article in much excitement, but it's really worth a read! "Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process" Names are important! #womenshealthmonth #DDUat20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
This is really good
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
#womenshealthmonth #threepillarsofwomenshealth
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
Congratulations to Prof Doreen Cantrell on her election to US-based National Academy of Sciences @nasonline.org #WomenInScience www.biodundee.co.uk/science-city...
biodundee.co.uk
Dundee scientist recognised with top international honour | Welcome to Bio-Dundee
A pioneering University of Dundee academic has received international recognition after being elected to one of the world’s foremost scientific institutions.
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Reposted by Drug Discovery Unit, University of Dundee
Wellcome Sanger Institute @sangerinstitute.bsky.social · 12/05/2026
Women’s health has long been underfunded and understudied. This Women’s Health Month, see how our researchers are using genomics to uncover new insights to improve outcomes for women worldwide. Read more: sangerinstitute.blog/2026/05/12/way…
The Pelvic Matters team with their zine.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
In March 2025, we hosted an #Endometriosis Networking Workshop with experts from across the field. We’re excited to share the resulting white paper! A huge thanks to all who contributed to these vital discussions. Read here: www.linkedin.com/posts/possib... #DrugDiscovery #WomensHealth #DDUat20
linkedin.com
Possible Strategies for Drug Discovery for Endometriosis | Drug Discovery Unit, University of Dundee
In March 2025, we convened an Endometriosis Networking Workshop, bringing together academics, clinicians, industry leaders, and venture capitalists to collaboratively explore how we can advance drug d...
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Reposted by Drug Discovery Unit, University of Dundee
Biochemical Society @biochemsoc.bsky.social · 11/05/2026
Final call for anyone interested in an opportunity to join our editorial boards and journals! Applications lose at midday today, 11 May 2026. Help shape the future of Society publishing, we are looking forward to hearing from you. Apply here for our current Spring cycle: ow.ly/1VvK50YXcH7
Top view of five people collaborating around a table with laptops and papers, promoting editorial board opportunities at Biochemical Society.
We're looking for people to become our Associate Editors and Editorial Board members. Open for applications. Visit our website to apply
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Reposted by Drug Discovery Unit, University of Dundee
PrecisionLife @precisionlife.bsky.social · 08/05/2026
New data presented at #EEC2026 identified and validated novel reproducible genetic risk factors associated with endometriosis across UK & US patient cohorts. 🎥 Watch the presentation: precisionlife.com/womens-healt... 📜 Read the preprint: www.medrxiv.org/content/10.1... #WomensHealthMonth
precisionlife.com
Endometriosis Genetic Risk Factors Identified and Validated
Watch Krystyna Taylor present PrecisionLife’s validation of genetic risk factors for endometriosis using combinatorial analysis.
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Reposted by Drug Discovery Unit, University of Dundee
Alzheimer's Association @alzassociation.bsky.social · 02/05/2026
Almost two-thirds of Americans with Alzheimer's are women. By adopting these healthy habits, we can all protect our brain health: alz.org/healthyhabits. #WomensHealthMonth
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Reposted by Drug Discovery Unit, University of Dundee
AAMC @aamc.org · 06/05/2026
When Elizabeth Blackwell became the first woman in the U.S. to earn an MD in 1849, her male classmates didn’t expect her to change medicine forever. This #WomensHealthMonth, explore what Blackwell’s legacy can teach us, 175+ years later.
aamc.org
A Lady Alone: The story of Elizabeth Blackwell, MD, the first female physician in the United States
Admitted to medical school on a whim, Blackwell became a dominant force in the fight for women’s health care and for the education of women physicians.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 10/05/2026
Relevant to #WomensHealthMonth!
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Nature @nature.com · 10/05/2026
Experienced researchers are less likely to produce ‘disruptive’ science than are those just starting their careers, finds an analysis of scientific papers published by 12.5 million researchers over 60 years go.nature.com/3Pb1lqg
go.nature.com
Early-career researchers do more ‘disruptive’ science than veterans
Nature - Analysis of papers from millions of scientists shows that older researchers tend to stick with ideas from their past.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 04/05/2026
So, let's talk about it! First off, we want to talk about the three pillars of women's health... #WomensHealthMonth #DDUat20 #GlobalHealth
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 04/05/2026
We would like to say in advance, for the purposes of these posts "women's health" encompasses people who were assigned female at birth. This is a scientific classification not a sociological one and nothing in here negates the lived experiences of trans people. #WomensHealthMonth
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 04/05/2026
Good morning sky-friends! We hope you are well on this lovely #mayday bank holiday! May is #WomensHealthMonth and we have lots of interesting things we want to talk about!
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 25/04/2026
"...a new antimalarial drug that has recently completed Phase 2 clinical trials in Africa, sponsored by @merckgroup.bsky.social. Cabamiquine is a very promising medicine.” Dr Beatriz Baragana #NowWeCanNowWeMust #WorldMalariaDay #DrugDiscovery #GlobalHealth #InfectiousDiseases #EndMalaria #DDUAT20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 25/04/2026
"Since 2010, the DDU malaria team, working with academic and industry partners, has been dedicated to discovering new medicines to treat and prevent malaria. One major success has been the discovery of Cabamiquine (DDD498)..." #NowWeCanNowWeMust #WorldMalariaDay #Research #EndMalaria #DDUAT20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 25/04/2026
..."before reactivating and causing repeated illness. Our goal is to develop a medicine that can fully clear this hidden infection and prevent malaria from returning." Dr Beatriz Baragana Ending malaria means tackling every stage of the disease. #NowWeCanNowWeMust #WorldMalariaDay #DDUAT20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 25/04/2026
“Over the past two years, we have also been working with @novartis.bsky.social to develop a new drug aimed at stopping malaria relapses. These relapses are caused by a form of malaria that can hide in the liver for months or even years after infection..." #NowWeCanNowWeMust #WorldMalariaDay
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 25/04/2026
To prevent this unnecessary loss of life, existing tools must reach every community at risk, & continued investment in the development of innovative medicines & prevention strategies is essential. Ending malaria starts with protecting those most at risk. #NowWeCanNowWeMust #WorldMalariaDay #DDUAT20
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 25/04/2026
Children under five and pregnant women are the most at risk from malaria, accounting for the majority of the approximately 600,000 deaths each year worldwide. #NowWeCanNowWeMust #WorldMalariaDay #EndMalaria #GlobalHealth #HealthEquity #DrugDiscovery #InfectiousDiseases #PublicHealth #DDUAT20
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