iiinova — where your digital self keeps evolving

Reposted by Daan C. Swarts

Daniel Tamarit @danieltamarit.bsky.social · 22/05/2026

I'm looking for an enthusiastic student to join my team as a PhD candidate on archaeal genome evolution 🦠💻 Work in beautiful Utrecht, at @binfutrecht.bsky.social, an international group full of caring, amazing scientists, and with frequent cake breaks! www.uu.nl/en/organisat... Please share! 🙏

uu.nl

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Reposted by Daan C. Swarts

New Concepts in Prokaryotic Virus-Host Interaction @spp2330.bsky.social · 18/05/2026

📢 Registration for our International Symposium on “New Concepts in Prokaryotic Virus-Host Interactions” is now open! 🗓️ 5–7 October 2026 📍 Harnack House, Berlin, Germany ➡️ Information and registration: spp2330.de/symposium-20...

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Reposted by Daan C. Swarts

Luuk Loeff @lloeff.bsky.social · 14/05/2026

Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures. www.biorxiv.org/content/10.6... A🧵

biorxiv.org

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Daan C. Swarts @dcswarts.bsky.social · 08/05/2026

#SISB2026 was fantastic! A big thanks to the organisers - super inspiring event!

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Reposted by Daan C. Swarts

Kenneth Loi @kenjmloi.bsky.social · 27/04/2026

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

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Jens Hör @jenshoer.bsky.social · 21/03/2026

Excited to share the first preprint from the lab! We show that ApeA defends against RNA phage infection by cleaving the phage genome: www.biorxiv.org/content/10.6...

biorxiv.org

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Rafal Mostowy @rafalmostowy.bsky.social · 04/05/2026

Polish phage science meets Polish visual storytelling 🇵🇱🦠 To celebrate our last paper, we collaborated with an artist who previously worked on The Witcher 3 — to create a comic about phages and why understanding them matters in the fight against antibiotic-resistant bacteria. Comic below 👇

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Daan C. Swarts @dcswarts.bsky.social · 09/04/2026

PostDoc position available! (links in post below) Feel free to share!

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Oleg Dmytrenko @olehdmy.bsky.social · 07/01/2026

Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...

nature.com

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature

Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...

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Daan C. Swarts @dcswarts.bsky.social · 02/12/2025

VERY much looking forward to cool science at the next edition of the Symposium of Immune Sytems of Bacteria in New York in 2026! Hope to see many of you there 🥳

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Reposted by Daan C. Swarts

Jack Bravo @jpkbravo.bsky.social · 02/12/2025

📢 We have multiple open PhD positions to study bacterial immune systems using cutting-edge cryo-EM, microbiology, and biochemistry in our group! Join us and uncover how bacterial defenses eliminate predators and engineer next-gen biotech tools. 🔥 Apply by Jan 8, 2026 Details: phd.pages.ista.ac.at

phd.pages.ista.ac.at

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Reposted by Daan C. Swarts

Svetlana Dodonova @dodonova-sveta.bsky.social · 28/10/2025

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

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Luuk Loeff @lloeff.bsky.social · 10/10/2025

One week left to apply!!

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Daan C. Swarts @dcswarts.bsky.social · 28/08/2025

BindCraft can be used to design synthetic protein binders with incredible accuracy and success rate - Out now in Nature. BindCraft displays perfectly how AI-based tools can be used to accelerate biological research (and clinical applications). I think this is a must-read paper.

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Daan C. Swarts @dcswarts.bsky.social · 14/05/2025

Fantastic work, congrats Anna! These filaments are so cool :)

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Daan C. Swarts @dcswarts.bsky.social · 13/05/2025

Out now: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-ce... Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?

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Gemma C. Atkinson @gemmaatkinson.bsky.social · 07/03/2025

Bioinformatics junior group leader position in Lund, specialising in infection and/or epidemiology. These are really nice positions with generous support. Please spread the word to anyone who might be interested in becoming our colleague! lu.varbi.com/en/what:job/...

lu.varbi.com

Associate Senior Lecturer (DDLS fellow) in data driven epidemiology and biology of infection

Lund is strategically positioned close to the continent, hosting major national and European research infrastructures, such as MAX.IV Laboratory and the European Spallation Source (ESS). In the field

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Daan C. Swarts @dcswarts.bsky.social · 23/01/2025

Excited to have been awarded an ERC Proof-of-Concept grant to further explore the possibilities to use prokaryotic Argonautes for diagnostics applications! 🥳

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Daan C. Swarts @dcswarts.bsky.social · 07/01/2025

🚨New review🚨 Evolution and ecology of anti-defence systems in phages and plasmids Link: www.cell.com/current-biol...

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Reposted by Daan C. Swarts

Luuk Loeff @lloeff.bsky.social · 31/12/2024

What a great way to end the year! ✨ Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system. tinyurl.com/4crj6dnx A long 🧵...

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Daan C. Swarts @dcswarts.bsky.social · 07/01/2025

Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports... It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...

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