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Diana Baquero

@dbaquero.bsky.social

30 followers 16 following 7 posts

Colombian Microbiologist | PhD

Posts Replies Media

Diana Baquero @dbaquero.bsky.social · 03/06/2025

Thank you!!

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Diana Baquero @dbaquero.bsky.social · 03/06/2025

Finally, I want to thank my mentor @mkrupovic.bsky.social , as well as @sgribaldo.bsky.social , Guillaume, and all the other colleagues from Institut Pasteur @institutpasteur.bsky.social for their support in this wonderful project!

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Diana Baquero @dbaquero.bsky.social · 03/06/2025

Here are the link to both studies: Weinberger et al., Nat Comms: www.nature.com/articles/s41... Baquero et al., Nat Comms: www.nature.com/articles/s41...

nature.com

Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon - Nature Communications

Baquero et al. show that extracellular vesicles produced by the dominant human-gut archaeon are likely formed by budding from the cell membrane and released through disruptions in the cell wall, and c...

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Diana Baquero @dbaquero.bsky.social · 03/06/2025

On the other hand, our colleagues (Weinberger et al., Nat Comms) used proteomics and metabolomics to study EVs from four human gut archaeal strains, revealing interesting cargos like adhesins, aspartic and glutamic acid, as well as notorious immune-stimulating properties.

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Diana Baquero @dbaquero.bsky.social · 03/06/2025

Our Cryo-ET data also sheds light on the biogenesis of M. smithii EVs. The results suggest they form by budding from the cell membrane and get trapped under the peptidoglycan layer before being released through disruptions in the cell wall.

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Diana Baquero @dbaquero.bsky.social · 03/06/2025

In our study, we show that EVs from Methanobrevibacter smithii — the predominant archaeon in the human gut — harbor proviral DNA and circular extrachromosomal DNA (eccDNA) that encodes key enzymes for methanogenesis, suggesting a potential impact on methane production in the gut.

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Diana Baquero @dbaquero.bsky.social · 03/06/2025

Kicking off my account with great news🎉: our latest paper on extracellular vesicles from human gut archaea is out in @natcomms.nature.com with @mkrupovic.bsky.social and @sgribaldo.bsky.social! Published in parallel with the work of our colleagues from the Moissl-Eichinger Lab @chmoei.bsky.social🧵

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