iiinova — where your digital self keeps evolving

Reposted by David Tingley

bioRxivpreprint @biorxivpreprint.bsky.social · 09/08/2026

A foundational in vivo platform for predicting human health outcomes www.biorxiv.org/content/10.64898/20…

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Reposted by David Tingley

bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 09/08/2026

A foundational in vivo platform for predicting human health outcomes www.biorxiv.org/content/10.64898/20…

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Reposted by David Tingley

Virginie M. S. Ruetten @vmsruetten.bsky.social · 08/09/2025

Thanks Misha for the shout-out! It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.

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David Tingley @davidtingley.bsky.social · 05/09/2025

You're not (at least that we've found).

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David Tingley @davidtingley.bsky.social · 12/04/2025

Agree it's a powerhouse team and backing, but HRS9531 (Kailera's lead program) isn't even close to best-in-class. Based on the human clinical data so far it'll be 4th place when approved, and competing with a better generic by 2032.

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David Tingley @davidtingley.bsky.social · 19/03/2025

Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.

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Reposted by David Tingley

Alex Knapp @thealexknapp.bsky.social · 19/03/2025

In this week's edition of our healthcare newsletter InnovationRx, @amyfeldman7.bsky.social & I look at: 💉 The Trump Administration's mixed messaging on vaccines. 🩺 Sex differences in side effects of GLP-1 medications 🤖 Using AI to predict epidemics And more! www.forbes.com/sites/innova...

forbes.com

InnovationRx: Trump Administration Sends Mixed Messages On Vaccines

In this week’s edition of InnovationRx, we look at the policy uncertainty around vaccines, sex differences in GLP-1 drug side effects, the challenges of using AI to predict epidemics and more.

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David Tingley @davidtingley.bsky.social · 19/03/2025

Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.

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Reposted by David Tingley

oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025

Check out what we're working on at Olio Labs! 70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men. What is driving this difference? We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:

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David Tingley @davidtingley.bsky.social · 28/02/2025

Congrats to Xuefeng and the authors on a great paper. academic.oup.com/sleep/advanc... Sometimes things do line up between species

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David Tingley @davidtingley.bsky.social · 05/12/2024

If anyone is interested in going this direction in their research feel free to reach out, I'm happy to discuss or brainstorm what kind of experiments could come next!

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David Tingley @davidtingley.bsky.social · 05/12/2024

In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate

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David Tingley @davidtingley.bsky.social · 05/12/2024

Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...

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David Tingley @davidtingley.bsky.social · 24/11/2024

Any chance I could get added? This was super helpful for finding everyone, thanks!

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