bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 05/10/2026Integrating Developmental Neurotoxicity Prediction with Adverse Outcome Pathway Reasoning www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 05/10/2026High-Throughput Morphological Profiling of Patient-Derived Human Liver Organoids for Hepatotoxicity Hazard Identification and Compound Prioritization www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Balancing receptor engagement and payload catalytic activity broadens the therapeutic window of immunotoxins www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Efficacy profiling of structurally diverse cannabinoid receptor ligands across transducer-coupling assays www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism www.biorxiv.org/content/10.64898/20… 020
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026DIFFERENTIAL ACTIVATION OF G-PROTEIN SUBTYPES BY DOPAMINE D1 RECEPTOR ALLOSTERIC MODULATION www.biorxiv.org/content/10.64898/20… 001
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Preclinical evaluation of the biodistribution, safety, and hemocompatibility of PEG-coated iron oxide magnetic nanoparticles in a viral oncogenesis mouse model www.biorxiv.org/content/10.64898/20… 100
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Pan-Coronavirus Protease Engagement and Differentiated Pharmacology of Antiviral Candidate CMX990 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Cooperative Peripheral CB1 Inhibition by Extracellular Antibody Binding and Orthosteric Antagonism www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/2026Sotagliflozin Reprograms Hepatic Lipid Metabolism and Attenuates Atherosclerosis Beyond Empagliflozin in CKM Mice www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 02/10/202610-Nitro-oleic acid improves survival following gamma irradiation and modulates hematopoietic and intestinal responses www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 01/10/2026Repurposing nystatin and taurocholate to target intracellular spore persistence during antibiotic treatment to prevent recurrent Clostridioides difficile infection. www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 30/09/2026A 3D in vitro follicle-endometrial organoid co-culture model recapitulates ovarian control of human endometrial decidualization www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 30/09/2026DCMax - A novel Delayed Cmax Drug Delivery System for Improved Chronotherapy www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 30/09/2026Histomonas meleagridis infection and vaccination protection in chickens -- a metabolomics study www.biorxiv.org/content/10.64898/20… 011
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 29/09/2026Assessing chemical toxicity across Eukaryota using multimodal transformers www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 29/09/2026Impact of GPR39 Inhibition on Tissue Oxygen Tension in Acute Myocardial Infarction: Modeling Using an Indirect Response Pharmacokinetics/Pharmacodynamics Approach www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 29/09/2026Surface charge tuning of lipid-polymer hybrid nanoparticles for optimized cilostazol delivery and platelet compatibility www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 29/09/2026Cytotoxic Effects of Multiple Pesticides and their Mixtures on Caco-2 Cells Evaluated by Using MTT and Trypan Blue Assays www.biorxiv.org/content/10.64898/20… 001
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 29/09/2026Translational Pharmacokinetics and Pharmacodynamics of a Cationic mRNA-Lipid Nanoparticle from Mice to Non-Human Primates www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 28/09/2026Context and exposure history shape insecticide sensitivity in Drosophila melanogaster www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 25/09/2026Aquaporin-9 and aquaporin-10 but not aquaporin-3 confer susceptibility to dimethylarsinic acid genotoxicity in human cells www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 25/09/2026Quantitative Systems Pharmacology Model for Trop-2 Targeting Antibody-Drug Conjugate in Triple-Negative Breast Cancer www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 25/09/2026Ethanol withdrawal induces temporally distinct alterations in oxytocinergic, opioidergic, glutamatergic and neuroimmune systems associated with recognition memory deficits www.biorxiv.org/content/10.64898/20… 010
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 25/09/2026Lipid lowering effects of Fucus vesiculosus and Phytolacca berry extracts: An alternative approach of treating hypertriglyceridemia www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 24/09/2026Computer-Assisted Systematic Chemical-Space Mapping of a First-in-Class Peripherally Restricted α2AAR Agonist through Scaffold-Seeded Enumeration www.biorxiv.org/content/10.64898/20… 001
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 23/09/2026Postnatal Development Shapes the Cardiac Response to Milrinone www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 23/09/2026Microswitch-Guided Sampling for the Detection of Ligand Signaling Bias in GPCR Systems www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 22/09/2026Identification of co-expressed gene sets for major molecular initiating events in rodent liver carcinogenesis using wild type and knock out rats www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 22/09/2026High-throughput phenotypic profiling of insecticide responses in mosquito larvae www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 21/09/2026EFFECTS OF SUBCHRONIC EXPOSURE TO POLYSTYRENE NANOPLASTICS ON THE MOUSE INTESTINE www.biorxiv.org/content/10.64898/20… 200
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 21/09/2026A non-retinoid triazolopyrimidine RBP4 antagonist for the treatment of Stargardt disease www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 21/09/2026ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 20/09/2026Hepatic Xanthine Oxidoreductase Sustains Antithrombotic Nitric Oxide Signalling Through the Nitrate-Nitrite-Nitric Oxide Pathway www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 19/09/2026The COVID-19 RNA vaccine SpikevaxTM transfects human umbilical endothelial cells and induces Spike protein production, inflammation and leukocyte adhesion www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 18/09/2026Cinnamaldehyde interacts with the local anesthetic pocket of the NaV 1.5 channel www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 18/09/2026Exposure to a mixture of long-chain PFAS disrupts ovarian follicle development, ovulation, and luteinization in female mice www.biorxiv.org/content/10.64898/20… 010
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 18/09/2026Multispecies translational evaluation of an NMDA receptor modulator reveals analgesic, autonomic-stabilizing, and stress mitigating effects without evidence of abuse liability www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 18/09/2026Genetically-encoded discovery and development of peptide-macrocycle imaging agents for PD-L1 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 17/09/2026Hepatotoxicity assessment of antimalarial compounds from microorganisms using a liver organ-on-a-chip system www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 17/09/2026Acute head shaking precedes chronic corpus callosum deficits during repeated cocaine exposure in common marmosets www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 16/09/2026Non-invasive quantification of hepatic necrosis from circulating alanine aminotransferase kinetics in acetaminophen-treated mice in vivo www.biorxiv.org/content/10.64898/20… 100
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 16/09/2026Replacing In Vivo Experiments for PK/PD Target Determination Through In Vitro Time-Kill Experiments and PK/PD Modelling Incorporating Inter-strain Variability: Application to Meropenem Against Pseudomonas aeruginosa www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 15/09/2026Protective effects of heat shock protein 70 induction against global warming by using oriental bezoar and ginseng www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 14/09/2026Comparative effects of central and peripheral PDE10A inhibition on weight gain following semaglutide cessation in diet-induced obese mice www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 14/09/2026Physicochemical compatibility and stability of urapidil-propofol admixtures during simulated Y-site Administration www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 14/09/2026Integrated pharmacological and structural profiling reveals CB1 residue interaction patterns associated with synthetic cannabinoid receptor agonist efficacy www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 14/09/2026Blockade of Kv3.1 by MK-801, a PCP-Derivative NMDA Receptor Inhibitor: Implications for Models of Schizophrenia www.biorxiv.org/content/10.64898/20… 000
bioRxiv Pharmacology and Toxicology @biorxiv-pharma.bsky.social · 12/09/2026Free fatty acid 2 receptor regulates the NADPH oxidase activity induced by formyl peptide receptor specific agonists www.biorxiv.org/content/10.64898/20… 000
