Karagiannis and Theodorou et al. show that excess lipids in obesity impair adipose ILC2s via acetyl-CoA carboxylase 1 (ACC1). Deletion of ACC1 disrupts the citrate shuttle and the NAD+/NADH balance, inducing ILC2 loss and adipose tissue hypertrophy. Supplementing with nicotinamide riboside rescues ACC1 deficiency and restores ILC2 and adipose tissue homeostasis.

Abstract figure legend Ten older healthy male adults underwent 10 days of bed rest. Vastus lateralis muscle biopsies were collected at baseline (PRE) and after 10 days of bed rest (BR10), and mitocho...

Abstract figure legend β-Hydroxy-β-methylbutyrate (HMB) enhances fast-twitch muscle and mitochondrial function in D2.mdx mice. Male DBA/2J (wild-type) and D2.mdx mice aged 3 or 6 months received dail....

(Cell Metabolism 16, 511–525; October 3, 2012)

We previously showed an acute intensity-dependent increase in circulating brain-derived neurotrophic factor (BDNF) after aerobic exercise, without a concurre...

The receptor for succinate SUCNR1 maintains hepatic metabolic flexibility and mitochondrial health.

Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training-induced changes in muscle morphology, function and gene networks relative to placebo ingestion...

Abstract figure legend This graphical abstract illustrates a novel, non-invasive approach to quantify mitochondrial oxygen (O2) affinity in vivo in human skeletal muscle using 1H magnetic resonance s...

Li et al. identify TMEM141 as a negative regulator of mitochondrial complex I assembly. Under high energy demand, the YME1L1 and AFG3L2 proteases degrade TMEM141, relieving its inhibition of the assem...

Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhi...

Systematic reviews and meta-analyses underpin clinical guidelines and health policy, yet their validity may be compromised by limited access to underlying datasets and associated analytical code. This...

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PDF | Sprint interval training (SIT) combined with post‐exercise blood flow restriction (BFR) can augment adaptive signalling responses in skeletal... | Find, read and cite all the research you need o...

Abstract figure legend This study used a non-targeted proteomic approach to explore the skeletal muscle determinants of peak fat oxidation (PFO) and the exercise intensity at which this occurs (Fatma....

Purpose Cross-sectional studies indicate that sprint performance is strongly associated with leg-muscle strength, however there is no consensus on which muscles to strengthen to maximize running speed...

Nature Metabolism, Published online: 27 May 2026; doi:10.1038/s42255-026-01535-7This study reveals that glycogen metabolism is crucial for the sensory activation of POMC neurons, which is necessary for proper feeding behaviour and metabolic health in mice.

Abstract figure legend This study examined whether supine cycling exercise, with or without artificial gravity, preserves resting metabolic rate (RMR) during 60 days of head-down tilt bed rest, and w...

Although 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a mor...

Aims/hypothesis Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear wheth...

The authors investigated metabolic remodeling in response to stem cell activation and the effect of aging on this response. Aging muscle stem cells lose a key glutamine-fueled metabolic pathway that p...

Precise control of antigen recognition remains a challenge in engineering cell-cell interactions. Kwon et al. develop extrabody, a split antibody platform that enables optogenetic and chemical control of extracellular antigen binding, allowing inducible cell-cell communication and programmable immune cell activation through synNotch and CAR systems.

Background Endurance performance is predicted by maximal oxygen uptake, its fractional utilisation at lactate threshold (FULT) and exercise economy. These variables are used to estimate speed or power...

Nature Metabolism, Published online: 08 May 2026; doi:10.1038/s42255-026-01530-yMetformin is shown to exert its glucose-lowering and additional clinical effects through inhibition of mitochondrial complex I in the intestinal epithelium in mice.

Nature Metabolism, Published online: 08 May 2026; doi:10.1038/s42255-026-01532-wMetabolomic analysis of plasma from metformin-treated humans, together with mechanistic studies in mouse models, reveals that metformin selectively inhibits mitochondrial complex I in the intestinal epithelium. This mechanism unifies multiple clinical effects of metformin, including enhanced intestinal glucose use, improved postprandial glycaemic control and increased production of GDF15 and N-lactoyl-phenylalanine.

Metformin is shown to exert its glucose-lowering and additional clinical effects through inhibition of mitochondrial complex I in the intestinal epithelium in mice.

This study reveals a non-canonical immunomodulatory function for the enzyme iNOS, based on the direct interaction in mitochondria with the itaconate-producing protein IRG1, which limits itaconate prod...

Recently retired, this professor emeritus reflects on how she challenged students to think beyond facts

Obesity might be to blame for part of the increase in cancer among young people, a study in the UK has found, but the causes largely remain a mystery

Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase (ATCase), leading to impaired pyrimidine biosynthesis and reduced proliferation under SDH inhibition.

GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse model...

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Abstract figure legend It is currently unknown whether the effects of low carbohydrate avalability on exercise-induced skeletal muscle signalling and adaptations are due to the low carbohydrate avail....

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability of hippocampal neurons and can be reversed by targeting Nell2.

Abstract figure legend The pharmacokinetics of lipophilic cationic radiotracers such as [99mTc]sestamibi and [99mTc]tetrofosmin are dependent on the electrical potentials that determine their distrib...

In vivo study shows diet-induced ER stress reprograms mRNA translation, promoting MASH and liver cancer progression.

Abstract figure legend Despite a low baseline capacity for mitochondria to utilize short-chain fatty acid (SCFA) to support oxidative phosphorylation, high-fat diet (HFD) consumption rewired mitochon....

Huertas et al. demonstrate that exercise dynamically modulates the assembly of mitochondrial respiratory complexes into supercomplexes in human skeletal muscle, with this remodeling being sex dependen...