Reposted by David LaursenCochrane Denmark & CEBMO @cochranedkcebmo.bsky.social · 29/09/2026Learn more about critically appraising diagnostic test accuracy (DTA) studies on 6 Oct on 12:00 CEST. In this webinar, Anne Rutjes will present the QUADAS-3 tool for assessing the risk of bias and applicability in DTA studies. www2.cochrane.dk/quadas-3/ 011
David Laursen @davidlaursen.bsky.social · 10/08/2026PRISMA 2020 is NOT intended to guide conduct, but reporting. Not uncommon for systematic reviews to write something like: “This review was conducted following the guidelines presented in PRISMA statement...” (freely modified) See our new study: onlinelibrary.wiley.com/doi/10.1002/... 1/4onlinelibrary.wiley.comPRISMA 2020 Is a Reporting Guideline for Systematic Reviews but Is Often Misused to Guide Review ContentIntroduction The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) is a reporting guideline aiming to facilitate transparent and accurate reporting in systematic reviews. T... 251
David Laursen @davidlaursen.bsky.social · 06/07/2026Do active placebo controls protect against bias from unblinding - and under what circumstances? And how do researchers develop active placebo controls? For Q1, go to the end. For Q2, see our new paper: www.jclinepi.com/article/S089... #ActivePlacebo #Blinding #Unblinding #Placebo 1/9 102
David Laursen @davidlaursen.bsky.social · 19/06/2026Happy to have defended my PhD successfully last week. If you want to read what my coauthors and I found out about active placebo controls and unblinding, the thesis is available here: portal.findresearcher.sdu.dk/files/308011... I hope to explore further in my upcoming postdoc.portal.findresearcher.sdu.dk 150
David Laursen @davidlaursen.bsky.social · 24/05/2026Looking forward to participating in this hybrid seminar and sharing study findings and reflections on blinding, unblinking and active placebo controls in randomised drug trials, on 31 August in Slagelse and on Zoom. #Blinding #Unblinding #Placebo #ActivePlacebo 221
Reposted by David LaursenThe John Snow Society @johnsnowsociety.bsky.social · 26/02/2026Thomas Wakley, the original editor of @thelancet.com was indeed no friend of Dr John Snow. In happier news, the journal published a 'corrected' obituary in 2013: www.thelancet.com/journals/lan... We're glad you had a refreshing visit to the John Snow pub @pwgtennant.bsky.social 😊thelancet.comJohn SnowPhysician, epidemiologist, and anaesthetist. Born in York, UK, on March 15, 1813, he died in London on June 16, 1858, aged 45 years. 2105
Reposted by David LaursenTom Rodebaugh @drrodebaugh.bsky.social · 22/02/2026Typo in student paper: Single-bling randomized control trialmedia.tenor.coma cat wearing sunglasses and a chain around its neck is sitting on a blue couch .Alt: a cat wearing sunglasses and a shiny chain around its neck is sitting on a blue couch looking fabulous. 3324
David Laursen @davidlaursen.bsky.social · 23/01/2026Causal inference coming to an unblinded trial near you! Hoping to read it more carefully soon and understand how it relates to previous efforts in measuring and handling unblinding (e.g. blinding indices) and to choice of control (e.g. active placebo) #Blinding #Masking #Unblinding #Unmasking 040
David Laursen @davidlaursen.bsky.social · 12/01/2026Errare humanum est ... (To err is human ...) While preparing my PhD thesis, I discovered some (minor) errors in which trials and meta-analyses were included for analysis in our meta-epidemiological study. 1/5 151
Reposted by David LaursenCochrane Denmark & CEBMO @cochranedkcebmo.bsky.social · 01/12/2025Webinar - read more and sign up: www.cochrane.org/events/how-t... On 17 February 2026, Andreas Lundh and Asbjørn Hrobjartsson will host a Cochrane Learning Live webinar about the TACIT tool.cochrane.orgHow to address conflicts of interests in systematic reviews using TACIT | Cochrane 051
David Laursen @davidlaursen.bsky.social · 12/11/2025... IN MICE 🐭 jamesheathers.medium.com/in-mice-expl... Vigtigt med retvisende overskrifter og passende forbehold for ekstrapolering til mennesker. #JustSaysInMice #InMice #IMusjamesheathers.medium.comIN MICE, explainedThe serious intent behind a wilfully dumb idea 000
Reposted by David LaursenGeorgia Tomova @georgiatomova.bsky.social · 10/11/2025Happening TODAY at 3pm GMT 👇 122
Reposted by David LaursenJack Wilkinson @jdwilko.bsky.social · 06/11/2025Have increased capacity for this December INSPECT-SR online training workshop following a successful 1st event today. Book here: www.trybooking.com/uk/FKHVtrybooking.comIntroduction to INSPECT-SR Training Workshop DecemberAn introductory 2-hour online workshop will introduce participants to the INSPECT-SR tool for assessing trustworthiness of randomised controlled... 0127
David Laursen @davidlaursen.bsky.social · 03/11/2025Recent trial with potential data problems @bmj.com. Great with IPD available for checking. Helpful/feasible with early standard checks in submission? E.g. onlinelibrary.wiley.com/doi/full/10....) or INSPECT-IPD (in development, www.sciencedirect.com/science/arti..., @jdwilko.bsky.social)onlinelibrary.wiley.comThe Individual Participant Data Integrity Tool for assessing the integrity of randomised trialsIncreasing concerns about the trustworthiness of research have prompted calls to scrutinise studies' Individual Participant Data (IPD), but guidance on how to do this was lacking. To address this, we... 020
Reposted by David LaursenCochrane Denmark & CEBMO @cochranedkcebmo.bsky.social · 20/10/2025What: Webinar on trial sequential analysis (TSA) in meta-analyses When: 28 Oct 2025 13:00 to 13:45 (CEST) Where: syddanskuni.zoom.us/j/61110310530 Christian Gunge Riberholt, associate professor at the University of Copenhagen, will talk about TSA and the potential errors of using it. #MetaAnalysis 011
Reposted by David LaursenGeorgia Tomova @georgiatomova.bsky.social · 18/10/2025Does anyone have any good examples of PPI for stats methodology? I’ve seen a few but they are all related to a clear applied research question, rather than actual methods 344
David Laursen @davidlaursen.bsky.social · 17/10/2025Does unblinding due to side effects lead to bias in placebo-controlled trials? And are active placebos a possible solution? (Spoiler alert: we are not sure.) #ActivePlacebo #ActivePlacebos #Blinding #Unblinding #Placebo #Bias 1/10 493
David Laursen @davidlaursen.bsky.social · 01/10/2025I forlængelse af sagen om SDU's pressemeddelelser - hermed lidt uformelle og inkomplette strøtanker til, når man skriver eller fortolker pressemeddelelser og anden videnskabelig kommunikation: 1/5 100
Reposted by David LaursenJack Wilkinson @jdwilko.bsky.social · 20/08/2025Last chance to participate - this will close on Sunday pm UK time. These results will be used to formulate guidance on demonstrating promise of an intervention when applying for funding for an RCT, pilot, or feasibility trial. 024
David Laursen @davidlaursen.bsky.social · 17/08/2025Hvad er #placebo? Hvor stor er placeboeffekten? Hvad gør man hvis blindede forsøgsdeltagere alligevel kan gætte deres behandling? Asbjørn Hróbjartsson og jeg er inviteret med i studiet hos Andreas Hoff for - måske - at komme nærmere på svarene på disse spørgsmål. open.spotify.com/episode/3aeI...open.spotify.com24 - om placeboMens Du Venter · Episode 000
Reposted by David LaursenCochrane Denmark & CEBMO @cochranedkcebmo.bsky.social · 07/08/2025Another round of workshops at SDU Odense to help you get started on your systematic review, scoping review, qualitative review, and other types of evidence synthesis: - 21 Aug 10am-12pm - 25 Sept 10am-12pm - 30 Oct 10am-12pm - 27 Nov 10am-12pm Read more and sign up: www.sdu.dk/en/forskning...sdu.dkMonthly methods workshopsWe offer monthly workshops on preparing systematic reviews. At the workshop, we introduce you to various types of reviews and guide you through the core steps of preparing them. 021
Reposted by David LaursenJournal of Clinical Epidemiology @jclinepi.bsky.social · 17/05/2025Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...jclinepi.comAssessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR projectThe aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks... 074
Reposted by David LaursenJack Wilkinson @jdwilko.bsky.social · 05/03/2025Funders expect evidence of 'promise' (the intervention is likely to work) when considering whether to fund an RCT, pilot, or feasibility study. But there is no shared understanding of how we should do this. We have been funded by @nihr.bsky.social to develop guidance to help. 22913
Reposted by David LaursenJocalyn Clark @jocalynclark.bsky.social · 04/02/2025Censor CDC scientists and ask them to withdraw papers from medical journals? This is not how it works, Mr President. Our response @bmj.com on the Trump Executive Order and his "forbidden words" www.bmj.com/content/388/... 651301521