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David A. Solomon

@david-solomon.bsky.social
31 followers 32 following 19 posts

brain tumor researcher and Director of Neuropathology at Stanford University School of Medicine, genomics and mouse models of brain and nerve sheath tumors, @StanfordHealth, @StanfordBrainTumorCenter, previously at UCSF Brain Tumor Center

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Reposted by David A. Solomon
Stanford Brain Tumor Center @stanfordbraintumor.bsky.social · 11/09/2026
We are proud to share that @david-solomon.bsky.social, associate professor & director of neuropathology at Stanford Medicine, will participate in the 2026 @theabta.bsky.social National Conference as a pathologist on the Brain Tumor Board. 🔬🧠 Learn more & register: abta.org/national-con...
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Reposted by David A. Solomon
UCSF Neurosurgery @neurosurgucsf.bsky.social · 11/04/2026
A phase 1 clinical trial led by @ucsfhealth.bsky.social neuro-oncologist Jennifer Clarke, MD, MPH, shows that a personalized treatment regimen with multiple targeted therapies is a feasible approach for recurrent #glioblastoma: braintumorcenter.ucsf.edu/news/precisi... @ucsfcancer.bsky.social
An illustration of DNA double helices is shown next to UCSF neuro-oncologist Jennifer Clarke, MD, MPH.
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David A. Solomon @david-solomon.bsky.social · 14/02/2026
It was a great pleasure to discuss our recent longitudinal genomic profiling studies of both IDH-wildtype glioblastomas and IDH-mutant astrocytomas together with Dr. Dave Rogawski of @stanfordbraintumor.bsky.social for the Neuro-Oncology podcast series: soc-neuro-onc.libsyn.com/hot-topics-h...
soc-neuro-onc.libsyn.com
Neuro-Oncology: The Podcast: Hot Topics: How longitudinal profiling of glioma informs therapy development
Dr. Dave Rogawski interviews Dr. David Solomon on his research that sheds light on how key genomic alterations in high-grade glioma evolve over time and how these insights might inform therapeutic dev...
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David A. Solomon @david-solomon.bsky.social · 08/02/2026
Full results of this first-in-class phase 1 clinical trial for recurrent glioblastoma now available online first ahead of print in Clinical Cancer Research -- aacrjournals.org/clincancerre...
aacrjournals.org
A genomically-tailored multi-agent precision medicine clinical trial for adults with recurrent glioblastoma
Abstract. Purpose: Existing salvage therapies for recurrent glioblastoma (rGBM) have limited efficacy, with median survival of approximately 9 months. Given the complex molecular heterogeneity of GBM,...
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David A. Solomon @david-solomon.bsky.social · 08/02/2026
Through longitudinal genomic profiling at GBM disease progression post trial therapy, we identified diverse genomic resistance mechanisms to such multi-agent targeted regimens that included MAPK to PI3K-mTOR pathway shift, acquired mismatch repair deficiency, and acquired MGMT gene amplification
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David A. Solomon @david-solomon.bsky.social · 07/02/2026
Promising efficacy using this genomically-tailored precision medicine approach relative to a comparator cohort of patients with recurrent glioblastoma treated with standard-of-care approaches without experimental agents, although toxicity from the treatment regimens was a substantial limitation
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David A. Solomon @david-solomon.bsky.social · 07/02/2026
Sponsored by the UCSF Glioblastoma Precision Medicine Program and led by the esteemed neuro-oncologist Dr. Jennifer Clarke, we tested 18 novel genomically-tailored multi-agent targeted therapy drug combinations in adults with recurrent glioblastoma. braintumorcenter.ucsf.edu/research/gli...
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David A. Solomon @david-solomon.bsky.social · 07/02/2026
Proud to share the results from our phase 1 clinical trial testing a genomically-tailored multi-agent treatment regimen in 30 adults with recurrent glioblastoma published today in aacrjournals.org/clincancerres. @CCR_AACR @neurosurgucsf.bsky.social t.co/niMlNGjgQ5
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David A. Solomon @david-solomon.bsky.social · 07/01/2026
Proud to share our new research lab website at @stanfordbraintumor.bsky.social and #StanfordPathology: med.stanford.edu/solomon-lab.html
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David A. Solomon @david-solomon.bsky.social · 07/12/2025
final O'ahu sunset at #SNO2025 before returning back to @stanfordbraintumor.bsky.social to continue in our collaborative quest to cure brain tumors
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David A. Solomon @david-solomon.bsky.social · 07/12/2025
So much exciting progress in the fight against #BrainTumors presented at this year's Society for Neuro-Oncology Annual Meeting #SNO2025. Thanks to all the incredible @neuroonc.bsky.social staff and colleagues around the world for putting this conference together! Looking forward to #SNO2026
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David A. Solomon @david-solomon.bsky.social · 07/12/2025
Thanks to support from the Gilbert Family Foundation's Curing Neurofibromatosis program, we are now building the first single cell atlas of NF1-associated gliomas spanning the different molecular subtypes & also both pre- and post-treatment tumors #SNO2025 gilbertfamilyfoundation.org/curing-neuro...
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David A. Solomon @david-solomon.bsky.social · 07/12/2025
Thanks to generous support from the Gilbert Family Foundation, Morgan Adams Foundation, Sandler Foundation, and Panattoni Family Foundation, we identified that gliomas arising in the setting of neurofibromatosis type 1 (NF1) are predominantly composed of three major molecular subtypes #BrainTumors
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Reposted by David A. Solomon
EANO @eanoassociation.bsky.social · 24/02/2025
A new open access article: cIMPACT-NOW update 9 – recommendations on genome-wide DNA methylation profiling for CNS tumor diagnostics – is now available in Neuro Oncology Advances 🔗 academic.oup.com/noa/article/... 🔓 #EANOessentials #NeuroOncology #MalignantBrainTumor
academic.oup.com
cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics
Abstract. Genome-wide DNA methylation signatures correlate with and distinguish central nervous system (CNS) tumor types. Since the publication of the init
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David A. Solomon @david-solomon.bsky.social · 21/10/2025
UMAP plot of the 23 methylation classes of kidney tumors we identified associated with distinct histologic features, genetic alterations, and clinical outcomes. Can now be used as the roadmap for more accurate classification of future patient tumor samples. Strong work Antonios, Omkar, and team!
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David A. Solomon @david-solomon.bsky.social · 21/10/2025
Fantastic multi-institutional collaboration with GU pathology colleagues at Stanford, UCSF, NIH, & NYU developing a DNA methylation-based classifier for human kidney tumors now in press at @modernpathology.bsky.social: www.modernpathology.org/article/S089...
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David A. Solomon @david-solomon.bsky.social · 19/10/2025
Great teamwork with Craig Horbinski and colleagues highlighting the necessity of molecular testing for the accurate diagnosis & treatment of #braintumor. Still championing for insurance approval of this testing in 2025 to ensure routine patient access @braintumor.org jamanetwork.com/journals/jam...
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David A. Solomon @david-solomon.bsky.social · 18/10/2025
It's an incredible honor to be embarking on the next phase of my physician-scientist career at @stanfordbraintumor.bsky.social & @stanfordmedicine.bsky.social with generous support from the NINDS/NIH, Gilbert Family Foundation, Ben and Catherine Ivy Foundation, and Morgan Adams Foundation
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David A. Solomon @david-solomon.bsky.social · 18/10/2025
It's been an incredible first year since joining this amazing group at @stanfordbraintumor.bsky.social & @stanfordnsurg.bsky.social. Looking forward to many more years of pioneering research, excellent patient care, and educating the next-gen of physician-scientists at @stanfordmedicine.bsky.social
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David A. Solomon @david-solomon.bsky.social · 18/10/2025
Dr. Nadeem Al-Adli presenting on our group's groundbreaking glioblastoma research at #SNO2024 identifying distinct patterns of epigenomic evolution of these #braintumors following therapy compared to IDH-mutant astrocytomas
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David A. Solomon @david-solomon.bsky.social · 18/10/2025
Dr. Calixto-Hope Lucas presenting on our group's groundbreaking glioblastoma research at #SNO2024
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David A. Solomon @david-solomon.bsky.social · 18/10/2025
Remembering fun times at #SNO2024 and looking forward to #SNO2025 in Honolulu in just a few short weeks with @neuroonc.bsky.social and colleagues from @stanfordnsurg.bsky.social & around the globe
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