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David J. Cutler

@davecutler.bsky.social

I am a population geneticist.

David J. Cutler @davecutler.bsky.social · 20/08/2024

Did you ever wonder how good any disease predictor based only on genetic data could be? Answer: it is a function of the heritability of the markers used, and might not be very high, without ~all~ the genetic variants identified. Figure 5. www.pivotscipub.com/hpgg/4/3/000...

pivotscipub.com

The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores

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David J. Cutler @davecutler.bsky.social · 20/08/2024

Did you ever wonder why polygenic risk scores seem so hard to interpret across populations? Answer: it is almost all due to allele frequency and LD differences. www.pivotscipub.com/hpgg/4/3/000...

pivotscipub.com

The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores

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David J. Cutler @davecutler.bsky.social · 16/12/2023

If you are looking for something actually really good on AppleTv the answer is SlowHorses! Among the better shows on any platform anywhere. Very, very smart, and Oldman is worth watching independent of plot.

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David J. Cutler @davecutler.bsky.social · 08/12/2023

This monster of paper is entirely open source, so if you find it at all useful, please share it with your friends and trainees. pivotscipub.com/hpgg/3/4/000...

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David J. Cutler @davecutler.bsky.social · 08/12/2023

Do you know what an additive by additive genetic interaction is? If you want to see a definition and a description for how to calculate such a thing for both quantitative and binary traits try pivotscipub.com/hpgg/3/4/000...

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David J. Cutler @davecutler.bsky.social · 08/12/2023

Have you ever wanted to know how to calculate heritability for a human disease? Have you ever wanted to know how to convert human genetics quantities like odds ratios or penetrance into their quantitative genetics equivalents? pivotscipub.com/hpgg/3/4/000...

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David J. Cutler @davecutler.bsky.social · 08/12/2023

Have you ever wanted to see a derivation of fundamental quantitative genetics results without any assumption of normal distributions? pivotscipub.com/hpgg/3/4/000...

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