iiinova — where your digital self keeps evolving

David J. Cutler

@davecutler.bsky.social

I am a population geneticist.

David J. Cutler @davecutler.bsky.social · 20/08/2024

Did you ever wonder how good any disease predictor based only on genetic data could be? Answer: it is a function of the heritability of the markers used, and might not be very high, without ~all~ the genetic variants identified. Figure 5. www.pivotscipub.com/hpgg/4/3/000...

pivotscipub.com

The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores

010

David J. Cutler @davecutler.bsky.social · 20/08/2024

Did you ever wonder why polygenic risk scores seem so hard to interpret across populations? Answer: it is almost all due to allele frequency and LD differences. www.pivotscipub.com/hpgg/4/3/000...

pivotscipub.com

The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores

020

David J. Cutler @davecutler.bsky.social · 08/12/2023

This monster of paper is entirely open source, so if you find it at all useful, please share it with your friends and trainees. pivotscipub.com/hpgg/3/4/000...

000

David J. Cutler @davecutler.bsky.social · 08/12/2023

Do you know what an additive by additive genetic interaction is? If you want to see a definition and a description for how to calculate such a thing for both quantitative and binary traits try pivotscipub.com/hpgg/3/4/000...

000

David J. Cutler @davecutler.bsky.social · 08/12/2023

Have you ever wanted to know how to calculate heritability for a human disease? Have you ever wanted to know how to convert human genetics quantities like odds ratios or penetrance into their quantitative genetics equivalents? pivotscipub.com/hpgg/3/4/000...

000

David J. Cutler @davecutler.bsky.social · 08/12/2023

Have you ever wanted to see a derivation of fundamental quantitative genetics results without any assumption of normal distributions? pivotscipub.com/hpgg/3/4/000...

030