iiinova — where your digital self keeps evolving

Darryl B McConnell @darrylbmcconnell.bsky.social · 10/12/2025

Drug discovery can be "short" (like 7.5 years for KRAS-G12C) or long (110 years for SGLT2 inhibitors).

060

Darryl B McConnell @darrylbmcconnell.bsky.social · 20/09/2025

BioNMR - still aggressively waiting to take off.

010

Reposted by Darryl B McConnell

Teddy Zartler @quantumtessera.bsky.social · 10/03/2025

Folks, it's that time again. I am planning the #YoungScientistNetworking for Spring. Do you want to share your journey in science (chemistry preferred) with people on social media? If so, DM me. Want to know what this looks like? Check out the hashtag on Twitter or Bluesky.

042

Darryl B McConnell @darrylbmcconnell.bsky.social · 15/01/2025

I continue to be astounded about how many rings there are to choose from for drug design and how many haven't been made yet.

0120

Darryl B McConnell @darrylbmcconnell.bsky.social · 10/01/2025

It’s important to be symmetrical in your assessment of both positive and negative data.

030

Reposted by Darryl B McConnell

Derek Lowe @dereklowe.bsky.social · 05/01/2025

Anyone expecting new medicines to spring out of Zeus's forehead like Athena, Goddess of Wisdom, will be disappointed. Everything is thanks to someone else, to a lot of someone elses. And others will work on what we did in turn. (10/10

1505

Reposted by Darryl B McConnell

NEJM.org @nejm.org · 10/12/2024

On this day in 1981, a landmark paper in NEJM described four patients with evidence of immunodeficiency associated with PJP pneumonia, disseminated CMV, and Kaposi sarcoma. The disease would come to be known as HIV/AIDS. Revisit the paper: nej.md/41iekKD #MedSky #IDSky

Published on This Day in 1981.
Pneumocystis carinii Pneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men — Evidence of a New Acquired Cellular Immunodeficiency

An illustration showing the reproductive cycle of human immunodeficiency virus type 1 (HIV-1) and sites of action of the major classes of antiretroviral medications.

The NEJM identity sits at the bottom.

12474217

Darryl B McConnell @darrylbmcconnell.bsky.social · 04/12/2024

Don't forget that water often likes to sit on top of pi systems (part of last week's lecture). Tonight we'll be getting in to how to build drugs (and of course McConnell's Rule of Two).

170

Darryl B McConnell @darrylbmcconnell.bsky.social · 28/11/2024

What to do with waters in drug discovery is one of the most important decisions that drug designers need to make. What would you do with the FLAP water on HIV protease? Address or Replace?

183

Reposted by Darryl B McConnell

Simon Kuestenmacher @simongerman600.bsky.social · 15/11/2024

Average pace of NYC Marathon finishers by age group. Amazing how everyone in the under 60 cohorts is remarkably close together. Source: buff.ly/3O1N2jI

1569

Darryl B McConnell @darrylbmcconnell.bsky.social · 20/11/2024

I'll post over the next week or so on H-bonds, especially enthalpically strong H-bonds, but before I do, just a reminder that two thirds of H-bonds that drugs form are actually weak. Check out the McConnellsMedchem post for more. mcconnellsmedchem.com/2023/06/04/i...

mcconnellsmedchem.com

160

Darryl B McConnell @darrylbmcconnell.bsky.social · 19/11/2024

Here's the Six Classes of Molecular Interactions for designing drugs and their frequencies in protein-ligand complexes. They are all very useful in drug design (except perhaps the last one). I'll post a few slides from my Medchem Uni course for each interaction over the coming days/weeks.

1715

Darryl B McConnell @darrylbmcconnell.bsky.social · 18/11/2024

For some reason in medicinal chemistry we like to use weight (Daltons) as a measure for atomic and molecular size. The picture below shows why this is hugely misleading for halogens and hydrogen.

0182

Darryl B McConnell @darrylbmcconnell.bsky.social · 16/11/2024

Heres the latest post on McConnell’s Medchem. Some medchem atoms are not as big as you think (especially the halogens) mcconnellsmedchem.com/2024/10/07/h...

mcconnellsmedchem.com

070

Reposted by Darryl B McConnell

Laura Howes @laurahowes.bsky.social · 15/08/2024

I have made a ChemSky starter pack and am posting here to help boost visibility. This list is not exhaustive, but should hopefully help newcomers or rejoiners find some accounts and feeds to follow go.bsky.app/C9BtrLj

34237121