iiinova — where your digital self keeps evolving

Reposted by Damian Toczydlowski

James Davies @jojdavies.bsky.social · 05/11/2025

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 20/09/2025

𝐆𝐫𝐞𝐠𝐨𝐫 𝐌𝐞𝐧𝐝𝐞𝐥'𝐬 𝐩𝐞𝐚 𝐩𝐥𝐚𝐧𝐭 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭𝐬, 𝐨𝐯𝐞𝐫𝐥𝐨𝐨𝐤𝐞𝐝 𝐟𝐨𝐫 𝐝𝐞𝐜𝐚𝐝𝐞𝐬, 𝐬𝐨𝐰𝐞𝐝 𝐭𝐡𝐞 𝐠𝐫𝐨𝐮𝐧𝐝𝐰𝐨𝐫𝐤 𝐟𝐨𝐫 (𝐄𝐩𝐢)𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 Do you recall the story of Gregor Mendel, the monk? Yes, that man, who with relentless passion, crossbred his pea plants in the quiet gardens of the Augustinian monastery. #science #genetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 17/09/2025

𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐦𝐞𝐦𝐨𝐫𝐲 𝐢𝐧 𝐚 𝐧𝐞𝐰 𝐥𝐢𝐠𝐡𝐭 It might sound like science fiction... But your cells actually have a form of memory. Not the kind you use to remember your grocery list, but something far more sophisticated. #epigenetics #science #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 22/03/2025

𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐚𝐜𝐫𝐨𝐬𝐬 𝐥𝐞𝐧𝐠𝐭𝐡 𝐬𝐜𝐚𝐥𝐞𝐬 At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling. What slowed down the progress? #epigenetics #genomics #crispr

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 16/03/2025

𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐭𝐡𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐬𝐞𝐥𝐟-𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐞? One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts. Do you know how it went at the beginning? #epigenetics #genomics #science

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 12/03/2025

𝐍𝐞𝐰 𝐬𝐭𝐞𝐦 𝐜𝐞𝐥𝐥𝐬 𝐰𝐢𝐭𝐡 𝐡𝐢𝐠𝐡 𝐩𝐥𝐚𝐬𝐭𝐢𝐜𝐢𝐭𝐲, 𝐥𝐨𝐰 𝐢𝐦𝐦𝐮𝐧𝐨𝐠𝐞𝐧𝐢𝐜𝐢𝐭𝐲, & 𝐧𝐨 𝐭𝐮𝐦𝐨𝐮𝐫 𝐫𝐢𝐬𝐤, 𝐭𝐡𝐚𝐭 𝐡𝐞𝐚𝐥 𝐬𝐤𝐢𝐧 𝐰𝐨𝐮𝐧𝐝𝐬 — 𝐂𝐚𝐧 𝐫𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐬𝐤 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞? I will only say that we haven't had a breakthrough like this in a long time. #regenerativemedicine #stemcells #science

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 11/03/2025

𝐀𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐚𝐥 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way. #epigenetics #genomics #chromatin

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 09/03/2025

𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐧𝐠 𝐑𝐍𝐀 & 𝐃𝐍𝐀 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐰𝐢𝐭𝐡 𝐌𝐄𝐑𝐅𝐈𝐒𝐇 𝐞𝐱𝐩𝐨𝐬𝐞𝐝 𝐜𝐞𝐥𝐥 𝐭𝐲𝐩𝐞–𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝟑𝐃 𝐠𝐞𝐧𝐨𝐦𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐭𝐡𝐞 𝐦𝐨𝐮𝐬𝐞 𝐜𝐞𝐫𝐞𝐛𝐫𝐚𝐥 𝐜𝐨𝐫𝐭𝐞𝐱 Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately. #epigenetics #epigenomics #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 05/03/2025

𝐆𝐞𝐧𝐞 𝐓𝐡𝐞𝐫𝐚𝐩𝐲: 𝐓𝐡𝐞𝐧, 𝐍𝐨𝐰, & 𝐁𝐞𝐲𝐨𝐧𝐝... Gene therapies wouldn't exist if we couldn't sequence the human genome. They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies. #genetherapy

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 02/03/2025

𝐇𝐨𝐰 𝐜𝐚𝐧 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐫𝐮𝐥𝐞𝐬 𝐨𝐟 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐞𝐥𝐞𝐦𝐞𝐧𝐭𝐬 𝐛𝐞 𝐝𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐞𝐝? "Sire, Your Grace, genome, tell us who we truly are," they said. At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history. #genomics #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 27/02/2025

𝐓𝐡𝐞𝐫𝐞 𝐰𝐨𝐮𝐥𝐝 𝐛𝐞 𝐧𝐨 𝐥𝐢𝐟𝐞, 𝐧𝐨 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐬𝐲𝐬𝐭𝐞𝐦𝐬 — 𝐰𝐞 𝐰𝐨𝐮𝐥𝐝 𝐧𝐞𝐯𝐞𝐫 𝐭𝐚𝐤𝐞 𝐨𝐮𝐫 𝐟𝐢𝐫𝐬𝐭 𝐛𝐫𝐞𝐚𝐭𝐡 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧... Transcription? For some, it is just a meaningless word. To others? A molecular process. #transcriptomics #epigenetics #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 24/02/2025

𝐓𝐡𝐞 𝐟𝐫𝐚𝐠𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 (𝐞𝐩𝐢)𝐠𝐞𝐧𝐨𝐦𝐞𝐬: 𝐍𝐨𝐭 𝐨𝐧𝐥𝐲 𝐃𝐍𝐀, 𝐛𝐮𝐭 𝐚𝐥𝐬𝐨 𝐑𝐍𝐀 𝐜𝐚𝐧 𝐛𝐞 𝐝𝐚𝐦𝐚𝐠𝐞𝐝 Nucleic acids are neither "immortal" nor made of iron. They can't be endlessly damaged. #genomics #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 22/02/2025

𝐬𝐦𝐋𝐢𝐯𝐞𝐅𝐈𝐒𝐇: 𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐬𝐦-𝐛𝐚𝐬𝐞𝐝 𝐯𝐢𝐬𝐮𝐚𝐥𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐬𝐢𝐧𝐠𝐥𝐞 𝐑𝐍𝐀 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞𝐬 𝐢𝐧 𝐥𝐢𝐯𝐞 𝐜𝐞𝐥𝐥𝐬 This new article from 𝘕𝘢𝘵𝘶𝘳𝘦 𝘉𝘪𝘰𝘵𝘦𝘤𝘩𝘯𝘰𝘭𝘰𝘨𝘺 is not only about a new method for imaging RNA molecules in living cells. #CRISPR #RNA #imaging

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Reposted by Damian Toczydlowski

The Groth lab @grothlab.bsky.social · 19/02/2025

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

tinyurl.com

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 20/02/2025

𝐂𝐑𝐈𝐒𝐏𝐑-𝐛𝐚𝐬𝐞𝐝 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐞𝐝𝐢𝐭𝐢𝐧𝐠 𝐮𝐧𝐜𝐨𝐯𝐞𝐫𝐬 𝐭𝐡𝐞 𝐦𝐢𝐬𝐬𝐢𝐧𝐠 𝐥𝐢𝐧𝐤𝐬 𝐢𝐧 𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐦𝐩𝐫𝐢𝐧𝐭𝐢𝐧𝐠 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫 This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies. #epigenetics #CRISPR #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 16/02/2025

𝐀 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐤𝐞𝐲 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐨𝐫 𝐨𝐟 𝐭𝐮𝐦𝐨𝐮𝐫 𝐚𝐠𝐠𝐫𝐞𝐬𝐬𝐢𝐯𝐞𝐧𝐞𝐬𝐬 𝐢𝐧 𝐩𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐨𝐧𝐜𝐨𝐥𝐨𝐠𝐲: 𝐑𝐍𝐀 𝐏𝐨𝐥𝐲𝐦𝐞𝐫𝐚𝐬𝐞 𝐈𝐈 𝐨𝐜𝐜𝐮𝐩𝐚𝐧𝐜𝐲 𝐚𝐭 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐠𝐞𝐧𝐞𝐬? Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲". #epigenetics #cancer #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 09/02/2025

𝐂𝐚𝐧𝐜𝐞𝐫 𝐢𝐧𝐡𝐮𝐦𝐚𝐧𝐞: 𝐖𝐡𝐲 𝐝𝐨 𝐦𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐭 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞𝐬 𝐝𝐞𝐟𝐲 𝐡𝐮𝐦𝐚𝐧 𝐥𝐨𝐠𝐢𝐜? Cancer is simply inhuman. Why can a single, mutated cell become a life-threatening danger to a human being? How can it destroy the entire organism, it belongs to. #epigenetics #cancer #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 07/02/2025

𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐛𝐥𝐚𝐜𝐤 𝐛𝐨𝐱: 𝐈𝐬 𝐞𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐭𝐡𝐞 𝐚𝐧𝐬𝐰𝐞𝐫 𝐭𝐨 𝐰𝐡𝐲 𝐨𝐧𝐥𝐲 𝐬𝐨𝐦𝐞 𝐜𝐞𝐥𝐥𝐬 𝐛𝐞𝐜𝐨𝐦𝐞 𝐦𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐭? It might sound a bit puzzling... But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell. #epigenetics #cancer #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 04/02/2025

𝐀 𝐛𝐥𝐮𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐨𝐫 𝐡𝐮𝐦𝐚𝐧 𝐭𝐡𝐨𝐮𝐠𝐡𝐭: 𝐓𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 & 𝐧𝐞𝐮𝐫𝐨𝐧𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲-𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝐠𝐞𝐧𝐞𝐬. Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli. #epigenetics #genomics #science

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 02/02/2025

𝐃𝐞𝐜𝐨𝐝𝐢𝐧𝐠 𝐌𝐞𝐧𝐝𝐞𝐥𝐢𝐚𝐧 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬 𝐰𝐢𝐭𝐡 𝐦𝐮𝐥𝐭𝐢-𝐨𝐦𝐢𝐜𝐬: 𝐂𝐨𝐮𝐥𝐝 𝐢𝐭 𝐛𝐞𝐜𝐨𝐦𝐞 𝐭𝐡𝐞 𝐠𝐨𝐥𝐝 𝐬𝐭𝐚𝐧𝐝𝐚𝐫𝐝 𝐢𝐧 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬? I love seeing more cases like this one from 𝘕𝘢𝘵𝘶𝘳𝘦 𝘎𝘦𝘯𝘦𝘵𝘪𝘤𝘴 journal. #epigenetics #genomics #multiomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 01/02/2025

𝐆𝐞𝐧𝐨𝐦𝐞-𝐒𝐡𝐮𝐟𝐟𝐥𝐞-𝐬𝐞𝐪: 𝐒𝐭𝐮𝐝𝐲𝐢𝐧𝐠 𝐭𝐡𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐜𝐨𝐧𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐞𝐬 𝐨𝐟 𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐯𝐚𝐫𝐢𝐚𝐧𝐭𝐬 (𝐒𝐕) 𝐚𝐭 𝐬𝐜𝐚𝐥𝐞 It's seriously impressive to see a method such powerful that can generate thousands of structural variants (in both human & mouse genomes) all in one experiment. #genomics #sequencing

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 31/01/2025

𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐬𝐡𝐚𝐩𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧? If anyone asked me how complex the field of Epigenetics is… I'd say it's mind-bogglingly complicated. There are a few reasons for that. #epigenetics #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 30/01/2025

𝐀 𝐠𝐞𝐧𝐨𝐦𝐞-𝐰𝐢𝐝𝐞 𝐚𝐭𝐥𝐚𝐬 𝐨𝐟 𝐡𝐮𝐦𝐚𝐧 𝐜𝐞𝐥𝐥 𝐦𝐨𝐫𝐩𝐡𝐨𝐥𝐨𝐠𝐲 Have I mentioned before that the future of functional (epi)genomics is probably going to be 𝐨𝐩𝐭𝐢𝐜𝐚𝐥 𝐩𝐨𝐨𝐥𝐞𝐝 𝐬𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠? If not, I'll say it again: #epigenetics #genomics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 18/01/2025

𝐖𝐚𝐧𝐭 𝐚 𝐧𝐨-𝐣𝐮𝐝𝐠𝐦𝐞𝐧𝐭, 𝐛𝐨𝐝𝐲-𝐰𝐢𝐝𝐞 𝐛𝐫𝐞𝐚𝐤𝐝𝐨𝐰𝐧 𝐨𝐟 𝐲𝐨𝐮𝐫 𝐧𝐚𝐧𝐨𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐭 𝐭𝐡𝐞 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐥𝐞𝐯𝐞𝐥? 𝐋𝐨𝐨𝐤 𝐧𝐨 𝐟𝐮𝐫𝐭𝐡𝐞𝐫. They say 90% of clinical trials fail for one simple reason: • Scientists are great at designing drugs, inventing fancy delivery systems & manufacturing them… #science #nanotechnology #research

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 13/01/2025

𝐆𝐞𝐧𝐞𝐫𝐚𝐥 𝐄𝐱𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧 𝐓𝐫𝐚𝐧𝐬𝐟𝐨𝐫𝐦𝐞𝐫 (𝐆𝐄𝐓): 𝐀𝐧 𝐢𝐧𝐭𝐞𝐫𝐩𝐫𝐞𝐭𝐚𝐛𝐥𝐞 𝐦𝐨𝐝𝐞𝐥 𝐭𝐡𝐚𝐭 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐬 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧𝐚𝐥 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐚𝐜𝐜𝐞𝐬𝐬𝐢𝐛𝐢𝐥𝐢𝐭𝐲 𝐝𝐚𝐭𝐚 The idea of predicting things in Science is alluring... #genomics #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 11/01/2025

𝐌𝐮𝐥𝐭𝐢-𝐨𝐦𝐢𝐜𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐜𝐥𝐢𝐧𝐢𝐜: 𝐂𝐚𝐧 𝐢𝐭 𝐭𝐫𝐮𝐥𝐲 𝐛𝐞𝐧𝐞𝐟𝐢𝐭 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬? Have you heard about multi-omics? It’s an approach that combines various "omics" layers — such as the genome, epigenome, transcriptome, proteome & many others. #omics #multiomics #cancer

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 10/01/2025

𝐈𝐬 𝐭𝐡𝐢𝐬 𝐭𝐡𝐞 𝐞𝐧𝐝 𝐨𝐟 𝐭𝐡𝐞 𝐬𝐡𝐨𝐫𝐭-𝐫𝐞𝐚𝐝 𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐢𝐧𝐠 𝐞𝐩𝐨𝐜𝐡 𝐢𝐧 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐢𝐜𝐬? Recently, a decent review titled "Profiling the epigenome using long-read sequencing" was published in the 𝑁𝑎𝑡𝑢𝑟𝑒 𝐺𝑒𝑛𝑒𝑡𝑖𝑐𝑠 journal. It carries a subtle suggestion: #epigenomics #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 08/01/2025

𝐀𝐈 𝐚𝐬 𝐚 𝐧𝐞𝐰 𝐢𝐧𝐭𝐞𝐫𝐧 𝐢𝐧 𝐭𝐡𝐞 𝐠𝐞𝐧𝐨𝐦𝐢𝐜𝐬 𝐥𝐚𝐛: 𝐖𝐡𝐚𝐭 𝐬𝐤𝐢𝐥𝐥𝐬 𝐜𝐚𝐧 𝐢𝐭 𝐭𝐫𝐚𝐢𝐧 𝐨𝐧? Whether we like it or not, we’re somewhat destined to live alongside AI. This technology floods our lives — sometimes very slowly. But this sudden surge — this wave — should carry us forward, not pull us back... #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 07/01/2025

𝐆𝐞𝐧𝐨𝐦𝐢𝐜 𝐥𝐚𝐧𝐠𝐮𝐚𝐠𝐞 𝐦𝐨𝐝𝐞𝐥𝐬 I came across this intriguing review about Genomic Language Models (gLMs). This could be super helpful for the genomics community. It highlights some key opportunities & challenges they present. #genomics #omics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 04/01/2025

𝐏𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐞𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐞𝐝𝐢𝐭𝐢𝐧𝐠 Did you know we can manipulate not only the genome but also the epigenome of cells? So, what exactly is epigenetic editing? #epigeneticscience #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 02/01/2025

𝐖𝐡𝐚𝐭 𝐢𝐬 𝐭𝐡𝐞 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞? Did you know that every cell in your body has its own distinct epigenome? Indeed, today, we’re going to explore something really alluring: your epigenomes! What exactly are they, & what makes each one unique? Okay, let’s dive in... #epigeneticscience #epigenetics

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 01/01/2025

Thanks to the many Giants of Science & great Thinkers over the centuries, we have made incredible progress. The last 24 years, especially, have seen remarkable advancements in Epigenetics. As we reflect on this time, let’s remember: #epigeneticscience #epigenomics #epigenetics

DNA double helix, a creative representation of DNA.

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Andrew C. Adey @acadey.bsky.social · 24/12/2024

Excited to have our sciMETv3 paper out today in Cell Genomics! We can produce hundreds of thousands of sibgle-cell DNA methylome libraries in a single experiment! (Plus lots more) www.cell.com/cell-genomic...

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 13/12/2024

𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐝𝐨𝐳𝐞𝐧𝐬 𝐨𝐟 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 𝐚𝐭 𝐨𝐧𝐜𝐞 𝐢𝐬 𝐧𝐨𝐰 𝐩𝐨𝐬𝐬𝐢𝐛𝐥𝐞. Human DNA is our shared heritage. After all, it's literally passed down from generation to generation. ▶️ Research: #epigeneticscience #epigenomics #epigenetics #singlecell #chromatin #cancer

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Lucas Farnung @lucas.farnunglab.com · 12/12/2024

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2

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Tomàs Montserrat Ayuso @tmontsay.bsky.social · 03/12/2024

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

bmcgenomics.biomedcentral.com

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 04/12/2024

𝐀 𝐧𝐞𝐰 𝐩𝐚𝐧𝐜𝐫𝐞𝐚𝐭𝐢𝐜 𝐨𝐫𝐠𝐚𝐧𝐨𝐢𝐝 𝐦𝐨𝐝𝐞𝐥 𝐟𝐚𝐢𝐭𝐡𝐟𝐮𝐥𝐥𝐲 𝐦𝐢𝐫𝐫𝐨𝐫𝐬 𝐭𝐡𝐞 𝐞𝐩𝐢𝐭𝐡𝐞𝐥𝐢𝐚𝐥 𝐜𝐨𝐦𝐩𝐚𝐫𝐭𝐦𝐞𝐧𝐭𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐡𝐮𝐦𝐚𝐧 𝐩𝐚𝐧𝐜𝐫𝐞𝐚𝐬 Have you heard about organoids already? Organoids are in vitro models created from engineered cells that replicate various features of the related in vivo tissues. #organoids #singlecell

Graphical abstract presenting the idea of article titled: Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

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Damian Toczydlowski @damiantoczydlowski.bsky.social · 01/12/2024

𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: 𝐀𝐫𝐞 𝐰𝐞 𝐩𝐮𝐥𝐥𝐢𝐧𝐠 𝐭𝐡𝐞 𝐫𝐢𝐠𝐡𝐭 𝐬𝐭𝐫𝐢𝐧𝐠𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞? Sometimes your initial ideas about what can be a "good target" might be totally wrong in light of new scientific evidence... ▶️ Review: #epigeneticscience #epigenomics #epigenetics #singlecell #chromatin #cancer

Epigenetics-targeted drugs: current paradigms and future challenges" discusses the emerging role of epigenetic agents in clinical oncology, particularly as adjuvants to traditional cancer therapies

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Oxford Nanopore @nanoporetech.com · 27/11/2024

We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them. Read more: nanoporetech.com/news/oxford-...

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Esteban Ballestar @eballestar.bsky.social · 19/11/2024

🚨 #Postdoc position 🚨 Join our lab at the #IJC in #Barcelona to lead innovative #Epigenetics & #SingleCell #Omics research on #SecondaryImmunodeficiency in #Leukemia patients, funded by #Grifols. institut-josep-carreras-ijc.jobs.personio.com/job/1760907?...

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