iiinova — where your digital self keeps evolving

Current Medical Science @currentmedscience.bsky.social · 3h

GBDT, integrated with APACHE II, strengthens mortality prediction in acute #Gastrointestinal bleeding patients, delivering reliable prognostic insights for clinical decision support. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Gastroenterology #ClinicalAI

Machine Learning-Based Mortality Prediction for Acute Gastrointestinal Bleeding Patients Admitted to Intensive Care Unit

000

Current Medical Science @currentmedscience.bsky.social · 05/10/2026

#Vitamin D activates Nrf2/HO-1 pathway to alleviate inflammation and injury after acute #CerebralInfarction, highlighting Nrf2’s role and VD’s therapeutic potential in #IschemicStroke. #medsky Learn more: doi.org/10.1007/s115... #currentmedicalscience #Neuroscience

Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction

011

Current Medical Science @currentmedscience.bsky.social · 04/10/2026

This study highlights a DNN model that significantly improves #ParkinsonsDisease diagnosis accuracy using spiral & wave handwriting, outperforming ML/DL models & advancing future diagnostics. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Neurotechnology#MachineLearning

Deep Learning-Based Diagnostic Model for Parkinson's Disease Using Handwritten Spiral and Wave Images

000

Current Medical Science @currentmedscience.bsky.social · 03/10/2026

Findings underscore the critical need for targeted interventions in severe pediatric #MentalDisorders. Early detection & management are essential to mitigate long-term developmental impacts. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Psychiatry #MentalHealth

Mental Disorder Spectrum in Children and Adolescents from 2014–2022: A Nine-year Epidemiological and Clinical Trend

011

Current Medical Science @currentmedscience.bsky.social · 02/10/2026

#Bcl2 family proteins regulate cell survival and death, with roles spanning autophagy, calcium #homeostasis, and mitochondrial dynamics, offering therapeutic promise through BH3 mimetics. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #CellBiology

Multifaceted Roles of Bcl-2 Family Proteins: Regulatory Roles in Apoptosis, Physiological Functions, and Therapeutic Potential

000

Current Medical Science @currentmedscience.bsky.social · 02/10/2026

Can #Microglia hold the key to stroke defense? Casr-related neuroprotection induced by ischemic preconditioning is linked to M2 microglial transformation, offering insight into #IschemicStroke defense. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Neuroscience

The Role of Casr Inhibition-Mediated M2 Microglial Transformation in Ischemic Preconditioning Against Stroke

012

Current Medical Science @currentmedscience.bsky.social · 01/10/2026

Findings show #PPA1 interacts with FUS to prevent mitochondrial mislocalization, preserving mitochondrial function & promoting adipose browning, highlighting its therapeutic potential in #MetabolicDisorders. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Metabolism

PPA1 Facilitates Thermogenesis in Brown and Beige Fat by Regulating the Mitochondrial Localization of FUS

000

Current Medical Science @currentmedscience.bsky.social · 30/09/2026

#UTROSCTs: rare uterine tumors with uncertain malignant potential. This study combines a literature review and 8 cases revealing novel markers and long term disease free outcomes. #medsky Full article: doi.org/10.1007/s115... #currentmedicalscience #Oncology #RareTumors

Clinicopathological and Molecular Characterization of Uterine Tumors Resembling Ovarian Sex Cord Tumors: An Eight-Case Series with Novel Fusion Gene Insights and Literature Review

031

Current Medical Science @currentmedscience.bsky.social · 30/09/2026

How does konjac oligosaccharide (KOS) improve gut motility? By activating the 5 HT4R/cAMP/PKA/p CREB pathway, KOS improves loperamide-induced #constipation, enhancing #IntestinalMotility. #medsky Read here: doi.org/10.1007/s115... #currentmedicalscience #laxative

Konjac Oligosaccharide Alleviates Constipation in Mice via 5-HT4R/cAMP/PKA/p-CREB Pathway Activation

001

Current Medical Science @currentmedscience.bsky.social · 29/09/2026

#Epigenetics offers new hope for #SNHL. This review explores #histone modifications, #DNAMethylation & ncRNAs in hair cell damage, highlighting small‑molecule compounds as promising therapies for SNHL. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience

Epigenetic Modifications in Sensorineural Hearing Loss: Protective Mechanisms and Therapeutic Potential

010

Current Medical Science @currentmedscience.bsky.social · 29/09/2026

#WorldHeartDay | September 29, 2026 #CardiovascularDisease remains a research priority, advancing prevention, early diagnosis, and #TranslationalMedicine. #CurrentMedicalScience publishes peer-reviewed #cardiovascularresearch and clinical innovation. Explore recent articles: t.co/5LdKznXcNc

000

Current Medical Science @currentmedscience.bsky.social · 28/09/2026

This study reveals that #Electroacupuncture activates GDNF/GFRα1/PI3K/Akt signaling, increases enteric glial cells, and improves gastrointestinal motility in #FunctionalDyspepsia. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Neurogastroenterology

Electroacupuncture Improves Gastrointestinal Motility in Rats with Functional Dyspepsia via the GDNF/GFRα1/PI3K/Akt Signaling Pathway

000

Current Medical Science @currentmedscience.bsky.social · 27/09/2026

#mRNAVaccines hold promise in #Oncology. This review highlights RNA design, lipid nanoparticle delivery, antigen encoding, and immunomodulators as strategies to overcome TME barriers in cancer #immunotherapy. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience

Development of mRNA Cancer Vaccines: Delivery Strategies and Immunogenicity Optimization

000

Current Medical Science @currentmedscience.bsky.social · 26/09/2026

By analyzing #CD8+, CD4+, NKT, and γδ T cells, this study underscores the promise of TCR‑T, #CART, and checkpoint inhibitors in achieving long‑term AML control and advancing future therapeutic strategies. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Oncology

T-Cell Responses and T-Cell-Based Therapy in Acute Myeloid Leukemia

000

Current Medical Science @currentmedscience.bsky.social · 25/09/2026

Study links decreased Akkermansia with higher inflammatory risk in unstable angina, pointing to the microbiota’s role in disease & the need for mechanistic clarity. @2024_HUST Read: doi.org/10.1007/s115... #currentmedicalscience #ClinicalScience #GutMicrobiota

Association of Decreased Fecal Microbiota Akkermansia with Increased
High‑Sensitivity C‑Reactive Protein Levels in Patients with Unstable

000

Current Medical Science @currentmedscience.bsky.social · 25/09/2026

This review highlights altered tryptophan #Metabolism in #obesity, underscoring its potential as a therapeutic target for metabolic and psychological comorbidities. #medsky Know more: doi.org/10.1007/s115... #currentmedicalscience #ClinicalScience

Tryptophan Metabolism in Obesity: Pathways, Mechanisms, and Therapeutic Perspectives

000

Current Medical Science @currentmedscience.bsky.social · 24/09/2026

Reciprocal activation between S100A9 and TLR2 amplifies hypertrophic signaling in mechanically stretched #cardiomyocytes, exacerbating maladaptive remodeling and likely accelerating HF progression, highlighting therapeutic targets. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience

Inflammation-Related Factors S100A9 and TLR2 in Cardiomyocyte Hypertrophy

000

Current Medical Science @currentmedscience.bsky.social · 23/09/2026

The global burden of PAH is rising unevenly, with high SDI regions seeing more cases. The study calls for equitable resources and better diagnostics. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Cardiology #HealthEquity #GlobalHealth

Global, Regional, and National Burden of Pulmonary Arterial Hypertension from 1990 to 2021 and Projections to 2040: A Systematic Analysis of Incidence, Mortality, and Disability-Adjusted Life Years

000

Current Medical Science @currentmedscience.bsky.social · 23/09/2026

Combination therapy shows promise in #schistosomiasis care. YCHD and PZQ reduce #granulomatous inflammation and #fibrosis by inhibiting apoptosis and ER stress, offering therapeutic promise. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Hepatology

Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice

010

Current Medical Science @currentmedscience.bsky.social · 22/09/2026

The #MUFA content of #Avocado oil varies by cultivar. This study highlights metabolic promise but calls for standardization of therapeutic applications across cultivars. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #FoodScience #ClinicalNutrition

Avocado Oil: Recent Advances in Its Anti-diabetic Potential

000

Current Medical Science @currentmedscience.bsky.social · 21/09/2026

This study demonstrates that #CHOP deficiency intensifies inflammation, epithelial #apoptosis, and injury in OAB mice by suppressing #ERStress, pointing to CHOP as a therapeutic axis. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Urology

Chop Deficiency Exacerbates Cyclophosphamide-Induced Overactive Bladder via Impaired Macrophage Apoptosis

000

Current Medical Science @currentmedscience.bsky.social · 21/09/2026

#WorldAlzheimersDay | September 21, 2026 Research in #AlzheimersDisease expands understanding of early detection and translational #neuroscience. Current Medical Science publishes peer-reviewed research in #neurodegeneration and clinical innovation. See recent studies: t.co/5LdKznXcNc

010

Current Medical Science @currentmedscience.bsky.social · 20/09/2026

This study summarizes the role of #TranscriptionFactors in #ALD pathology—from lipid metabolism to ER stress—and highlights promising targeted therapies for ALD treatment. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Hepatology #Epigenetics

Key Transcription Factors: Avenue for Treating Alcoholic Liver Disease

001

Current Medical Science @currentmedscience.bsky.social · 19/09/2026

SIC raises mortality; pre‑SIC increases risk. A #nomogram-based prediction model enables early SIC identification, improving #sepsis management & outcomes. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Epidemiology #IntensiveCare

Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy: A Multicenter Retrospective Study

000

Current Medical Science @currentmedscience.bsky.social · 18/09/2026

Can a natural compound protect the #Liver from alcohol induced iron overload? This study reveals that #quercetin sustains ferritinophagic flux & lysosomal function via #FOXO1 TFEB NCOA4 signaling. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Hepatology

The Protective Effects of Quercetin on Ferritinophagy in Alcoholic-Induced Liver Iron Overload

000

Current Medical Science @currentmedscience.bsky.social · 18/09/2026

SAE drives high morbidity and mortality. This review shows how #lncRNAs modulate #inflammation, metabolism, and immune function — impacting the blood brain barrier and neurons. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Neurobiology #Sepsis

Unveiling the Role of LncRNA in Sepsis-Associated Encephalopathy

010

Current Medical Science @currentmedscience.bsky.social · 17/09/2026

#Sepsis therapy breakthrough: #electroacupuncture at BL23 enhances antibiotic efficacy by modulating PVN activity and controlling systemic #inflammation, revealing a novel #neuroimmunological pathway for critical care. #medsky Read: doi.org/10.1007/s115...

Electroacupuncture-Medication Combined Therapy Improves Sepsis Outcomes by Regulating PVN Neuronal Activities

130

Current Medical Science @currentmedscience.bsky.social · 16/09/2026

#Multiomics analysis links #Ferroptosis risk groups to HCC’s immune microenvironment. #GRINA inhibition induces mitochondrial damage & ferroptosis in HCC cells, offering a novel therapeutic strategy. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Oncology

Cellular Membrane Protein GRINA is Highly Expressed and Associated with Survival Outcomes in Liver Cancer Patients

000

Current Medical Science @currentmedscience.bsky.social · 15/09/2026

#PMEPA1 impairs Treg‑mediated #immunosuppression by hyperactivating PI3K/AKT, fueling ESC invasiveness in #Endometriosis. Targeting this axis may restore immune balance and curb progression. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Immunology

PMEPA1-Mediated Treg Cell Impairment Promotes Endometrial Stromal Invasion via Excessive PI3K/AKT Signaling in Endometriosis

000

Current Medical Science @currentmedscience.bsky.social · 14/09/2026

This review highlights #sialylation as a key regulator of OC progression, metastasis, and drug resistance, pointing toward novel therapeutic strategies. #medsky Learn more: doi.org/10.1007/s115... #currentmedicalscience #Oncology #Glycosylation

Aberrant Sialylation in Ovarian Cancer: Orchestrating Progression, Metastasis, and Therapeutic Hurdles

010

Current Medical Science @currentmedscience.bsky.social · 13/09/2026

This review highlights how #optogenetics dissects neural mechanisms using light to precisely activate or inhibit specific neurons, combined with behavioral & #electrophysiological analyses. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Neuroscience #Neurobiology

Application of Optogenetic Neuromodulation in Regulating Depression

020

Current Medical Science @currentmedscience.bsky.social · 12/09/2026

#miR146a plays a central role in #neuroinflammation across NDDs. This review highlights its promise as both a biomarker and therapeutic target, paving the way for precision #Neurology. #medsky Know more: doi.org/10.1007/s115... #currentmedicalscience #Neuroscience

miR-146a Regulates Neuroinflammation and Immune Cell Function in Neurodegenerative Diseases

011

Current Medical Science @currentmedscience.bsky.social · 11/09/2026

Systematic review shows how #AI can transform #TraditionalChineseMedicine practices into structured clinical decision systems, enhancing medical decision-making. #medsky Know more: doi.org/10.1007/s115... #currentmedicalscience #Bioinformatics #MedicalAI

Artificial Intelligence for Spleen-Stomach Disorders in Traditional Chinese Medicine: Integrating Knowledge Graphs with Intelligent Diagnosis and Treatment

000

Current Medical Science @currentmedscience.bsky.social · 11/09/2026

AR-positive #TNBC offers a vital target, but single-agent anti-AR therapies hit steep clinical hurdles. This review outlines how combining AR antagonists with other therapeutic strategies overcomes resistance. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Oncology

Current Status and Advances in Anti-Androgen Therapy for Triple-Negative Breast Cancer

010

Current Medical Science @currentmedscience.bsky.social · 10/09/2026

Why is #CD44v6 exciting in AML? #Decitabine treatment increases CD44v6 expression on DNMT3A-mutant AML cells, improving recognition & targeting by #CARTcells. A promising step toward precision #Immunotherapy. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Oncology

CD44v6 CAR-T Cells Target DNMT3A-Mutant AML: Synergistic Enhancement by Decitabine

000

Current Medical Science @currentmedscience.bsky.social · 09/09/2026

Elevated #S100A8/A9 drives abnormal #proliferation, migration, #adhesion & #Chemoresistance in #DNMT3A mutant AML. Targeting this pathway could be a promising therapeutic strategy. #medsky Read more: doi.org/10.1007/s115... #currentmedicalscience #Oncology #CancerTherapeutics

Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells

010

Current Medical Science @currentmedscience.bsky.social · 09/09/2026

A detailed toxicity profile of SG drugs is revealed through #ClinicalTrial data & FRAES/DDInter, uncovering new adverse reactions & drug interactions, advancing #Pharmacovigilance. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Pharmacology #Toxicology #DrugSafety

Toxicities Associated with Sacituzumab Govitecan: Data from Clinical Trials and a Real-World Pharmacovigilance Database

000

Current Medical Science @currentmedscience.bsky.social · 08/09/2026

#Computational data clarify how SZKJT activates #Phytochemicals to treat OSCC. This study provides mechanistic insights into phytochemical-based #CancerTherapy. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Oncology #TranslationalOncology #Phytotherapy #Cancer

Integrative Network Pharmacology and Molecular Docking Analyses on the Mechanisms of San-Zhong-Kui-Jian-Tang in Treating Oral Squamous Cell Carcinoma

000

Current Medical Science @currentmedscience.bsky.social · 07/09/2026

This review explores how #AerobicExercise reshapes molecular pathways, highlighting it as a #Nonpharmacological intervention with broad medical applications. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Neurobiology #ExerciseScience #AnxietyResearch #anxiety

Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders

010

Current Medical Science @currentmedscience.bsky.social · 06/09/2026

Study reveals #cardioprotective role of ANP in #ReperfusionInjury. ANP reduces #myocardial I/R injury by modulating Zn²⁺ homeostasis — pointing to new therapeutic strategies in #CVD. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Cardiology #TherapeuticTargets

ANP Increases Zn2⁺ Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts

000

Current Medical Science @currentmedscience.bsky.social · 05/09/2026

#PeriodontalDisease causes #BoneLoss & #Inflammation. Study shows GSK J4 attenuates these effects by targeting #JMJD3 — highlighting #epigenetic modulation as a promising therapeutic strategy. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Dentistry #OralSurgery

The Histone Demethylase Inhibitor GSK-J4 Attenuates Periodontal Bone Loss and Inflammation in a Rat Model of Periodontitis

010

Current Medical Science @currentmedscience.bsky.social · 04/09/2026

#Celegans is advancing #VirusHostInteraction research. From #Antiviral #RNAi & #InnateImmune responses to #ReverseGenetics for Orsay virus, #nematodes provide a simple yet powerful model. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Virology #ModelOrganisms

Insights into Virus-Host Interactions: Lessons from Caenorhabditis elegans-Orsay Virus Model

110

Current Medical Science @currentmedscience.bsky.social · 04/09/2026

What’s driving the future of #GeneTherapy? Learn in this review how #Adenoassociatedviruses are crucial in gene therapy for #GeneticDiseases, driving the future of #PrecisionMedicine & #BiomedicalInnovation. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Genetics

Advances and Challenges in Adeno-Associated Virus Gene Therapy Applications of Localized Delivery Strategies

000

Current Medical Science @currentmedscience.bsky.social · 03/09/2026

#ALOX5 is a reliable diagnostic marker in #DKD, linked to immunity and #Ferroptosis. This strengthens prospects for precision #Diagnostics and patient care. #medsky Know more: doi.org/10.1007/s115... #currentmedicalscience #Nephrology #Biomarkers #ClinicalResearch

Identification of Immune-Related Ferroptosis Biomarkers in Diabetic Kidney Disease and Screening of Associated Inhibitors

010

Current Medical Science @currentmedscience.bsky.social · 02/09/2026

Study shows dysregulated #immune infiltration drives #Sepsis induced ALI, highlighting novel targets for precision #immunomodulation and #Biomarker development in critical care. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #CriticalCare #AcuteLungInjury

Immune Dysregulation and Hub Gene Identification in Non-Pulmonary Sepsis-Induced Acute Lung Injury: Insights from Transcriptomic and Experimental Analyses

010

Current Medical Science @currentmedscience.bsky.social · 02/09/2026

Could #NOX4 reshape #ColorectalCancer therapy? This study shows that NOX4 acts as a #Ferroptosis suppressor and reveals a metabolic vulnerability, spotlighting NOX4 as a therapeutic target. #medsky Read: doi.org/10.1007/s115... #currentmedicalscience #Oncology #CancerTherapy

NOX4 Suppresses Ferroptosis Through Regulation of the Pentose Phosphate Pathway in Colorectal Cancer

000

Current Medical Science @currentmedscience.bsky.social · 01/09/2026

#Inflammatory diets accelerate biological aging, driving #CKM syndrome progression. Dietary interventions are critical & longitudinal studies will clarify mechanisms. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #NutritionScience #HealthyAging #AgingResearch

Association Between Inflammatory Dietary Pattern and Cardiovascular-Kidney-Metabolic Syndrome: A Population-Based Study

011

Current Medical Science @currentmedscience.bsky.social · 31/08/2026

This study provides the first comprehensive characterization of exosome-derived metabolites in #SLE and establishes a prediction model for SLE vs. #LN discrimination. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Immunology #Nephrology #PrecisionMedicine

Machine Learning-Based Identification of Novel Exosome-Derived Metabolic Biomarkers for the Diagnosis of Systemic Lupus Erythematosus and Differentiation of Renal Involvement

010

Current Medical Science @currentmedscience.bsky.social · 30/08/2026

Study introduces the first multimodal #3DAtlas for #BCIResearch to explore #BrainTissue structure–function relationships and advance understanding of #BCI operational principles. #medsky To read: doi.org/10.1007/s115... #currentmedicalscience #Neuroscience #BrainAtlas

Construction of a Multimodal 3D Atlas for a Micrometer-Scale Brain–Computer Interface Based on Mixed Reality

010