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CryoCloud @cryocloudio.bsky.social · 21/08/2026

v2.40 is live 🚀 Bringing you: Class flow plots · AutoClass2D results page · dynamic masking in Refine3D · 1.5× faster classifications and refinements. Video + release notes 👇 academics can sign up for free here: app.cryocloud.io #cryoEM #structuralbiology #SPA

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CryoCloud @cryocloudio.bsky.social · 19/08/2026

3D ligand visualisation is now built directly into the CryoCloud project table, allowing you to quickly inspect ligands across 100s of datasets in seconds. Interested in our CrystalCloud add-on? Email hi@CryoCloud.io #cryoEM #structuralbiology #drugdiscovery #biotech #CryoCloud #MX #crystallography

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CryoCloud @cryocloudio.bsky.social · 06/07/2026

CryoCloud v2.34 is out! Highlights include Live Analysis for real-time cryo-EM image processing, an Interactive Masking tool, Ligand Visual Inspector, and MolProbity validation. Find the full release notes here: connect.cryocloud.io/release-note... #cryoEM #structuralbiology

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CryoCloud @cryocloudio.bsky.social · 25/03/2026

CryoCloud Map of the Month: TRPV3 in lipid nanodisc We reprocessed EMPIAR-10400 using CryoCloud and achieved: 🚀 3.1 Å resolution (vs. 3.3 Å published) ⚡ 7 compute hours total Curious what your data would look like reprocessed with CryoCloud? 📧 hi@cryocloud.io

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CryoCloud @cryocloudio.bsky.social · 18/03/2026

🌟 Employee Spotlight: Gydo van Zundert Gydo brings a rare blend of scientific depth and product vision to CryoCloud. He leads our R&D team of scientific software developers, driving the development of novel algorithms and next-generation methods for #cryoEM data analysis. #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 16/03/2026

CryoCloud will be at the @instruct-eric.bsky.social Best Practices in Cryo-EM Workshop in Milan this week. On March 18, we’ll present a flash talk on how #CryoCloud can help #cryoEM facilities manage users, data storage, and scalable compute. Come say hi! 🔗 instruct-eric.org/events/best-...

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CryoCloud @cryocloudio.bsky.social · 13/03/2026

🚀 CryoCloud v2.23 is live 🔎 More visualisation in results pages: FSC curves and angular distribution plots (see GIF 👇) ⚡ Faster map viewing: cropped & downsampled map variants now load much faster in the UI 📘 connect.cryocloud.io/release-note... #CryoCloud #CryoEM

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CryoCloud @cryocloudio.bsky.social · 12/03/2026

🚨 CryoCloud Newsletter Alert Over the past few months, we’ve released multiple platform updates, published new technical content, launched our new website, and connected with the structural biology community at SBDD San Diego. 🔗 Full issue: connect.cryocloud.io/newsletter-m... #CryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 10/03/2026

Get started with CryoCloud: 👉 Learn more & book a call: cryocloud.io 👉 Sign up directly: app.cryocloud.io/sign-up 👉 Explore the docs: docs.cryocloud.io 📫 hi@cryocloud.io

cryocloud.io

Cloud-Powered Cryo-EM Data Analysis | CryoCloud

Accelerate cryo-EM research with cloud-native infrastructure. No queues, no hardware, no setup. From raw data to high-resolution structures in hours.

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CryoCloud @cryocloudio.bsky.social · 10/03/2026

We’ve had many new followers recently, so for those who may be new to CryoCloud — here’s a quick overview of how you can try the platform: tinyurl.com/yrb6vwc4 There are two ways to get started: 🔹Free academic account, or 🔹30-day evaluation trial Links are in the comments 👇 #CryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 05/03/2026

📅 April 21 - Industry How automation and scalability support high-throughput cryo-EM workflows in industry. events.teams.microsoft.com/event/1115ab...

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CryoCloud @cryocloudio.bsky.social · 05/03/2026

📅 April 16 - Academia An introduction to cryo-EM data processing workflows and how academic researchers can get started using CryoCloud. events.teams.microsoft.com/event/222296...

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CryoCloud @cryocloudio.bsky.social · 05/03/2026

🚀 CryoCloud Webinar Series Cryo-EM datasets are getting larger, but processing them shouldn’t be harder. Join our April webinars on cryo-EM data processing and automated workflows with CryoCloud. 📅 Apr 16 - Academia 📅 Apr 23 - Industry Live demo + Q&A #CryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 03/03/2026

What does single particle analysis on CryoCloud look like? From dataset creation to particle picking and 2D/3D classification, here’s a short walkthrough: cryocloud.io/solution/end... Request a free academic account or a 30-day trial here: app.cryocloud.io/sign-up #CryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 26/02/2026

February Map of the Month: Aca2–RNA We reprocessed EMPIAR-11918 and achieved 2.76 Å in 50.5 compute hours. Sub-3 Å at ~40 kDa is a strong example of what modern cryo-EM workflows (and RELION with Blush) can deliver for small targets. 📧 hi@cryocloud.io #CryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 24/02/2026

🌟 Employee Spotlight: Thijmen van Buuren Over the past two years, Thijmen has strengthened CryoCloud’s automation workflows, advancing our research infrastructure and scalable data pipelines. As he wraps up his time with us, we thank him for his dedication and impact. All the best, Thijmen! 🚀

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CryoCloud @cryocloudio.bsky.social · 20/02/2026

🚀 CryoCloud v2.22 is live! What's new: 🧬 cryoDRGN-AI Ab Initio now available (see the GIF👇) ⚡ GPU-accelerated MotionRefine CC (alpha): 2–3× faster polishing 📊 Redesigned project overview 📺 Embedded viewers in multiple jobs 🔗 connect.cryocloud.io/release-note... #CryoEM #cryoDRGN

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CryoCloud @cryocloudio.bsky.social · 17/02/2026

🚀 We’ve launched a new CryoCloud website! CryoCloud has grown significantly over the past few years – more users, more deployments & ongoing technical development across infrastructure and automation. It was time for a website that reflects that evolution. 🌐 Take a look: www.cryocloud.io #cryoEM

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CryoCloud @cryocloudio.bsky.social · 13/02/2026

🚨 New blog: Automated cryo-EM analysis of the gastric proton pump We reprocessed EMPIAR-11057 using a fully automated end-to-end workflow: ⚡ 2.6 Å in 43.5 hr (vs 2.8 Å published) ⚡ 2.4 Å after CTF refinement ⚡ Improved ligand density 🔗 Full article: docs.cryocloud.io/blog/ #cryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 27/01/2026

🚀 CryoCloud v2.21 is live! This release delivers a major update to the workflows experience in CryoCloud: 🔹 Convert an existing project into a reusable workflow 🔹 Apply workflows mid-project to extend or repeat processing steps 📘 connect.cryocloud.io/release-note... #CryoCloud #CryoEM

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CryoCloud @cryocloudio.bsky.social · 22/01/2026

January Map of the Month: Gastric Proton Pump – Revaprazan Complex 🤖 2.6 Å map in 43h, fully automated, no user input 💡 All automation features are available to all CryoCloud users Curious how your data would look reprocessed with #CryoCloud? 📧 hi@cryocloud.io #cryoEM #DrugDiscovery

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CryoCloud @cryocloudio.bsky.social · 19/01/2026

And because everyone loves GIFs – here are a few particularly icy micrographs, easily spotted using the new CryoCloud Picker filter 🔎❄️

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CryoCloud @cryocloudio.bsky.social · 19/01/2026

🚀 CryoCloud v2.20 is live! This release introduces advanced job-branch cloning (see ⬇️), contamination-based filtering, and several performance improvements across the platform. 📘 Full release notes → connect.cryocloud.io/release-note... #CryoCloud #CryoEM

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CryoCloud @cryocloudio.bsky.social · 15/01/2026

🌟 Welcome to the team, Paddy O'Brien! 🇮🇪 We’re thrilled to welcome Paddy as our new Structural Biology Applications AI Intern. Fun fact: Paddy adds another nationality to CryoCloud’s already diverse mix, bringing us to 8 nationalities and counting! 🍀 Welcome aboard, Paddy! 🙌 #CryoCloud #CryoEM

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CryoCloud @cryocloudio.bsky.social · 14/01/2026

🔎 Before diving into new 2026 data, we’re looking back at the highlights from the last six months. ⚡️From receptors to kinases and fibrils, each dataset was reprocessed in CryoCloud, often within <2 days, and all resolved to high-quality maps between 2.3 and 3.2 Å. #CryoEM

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CryoCloud @cryocloudio.bsky.social · 08/01/2026

Get started with CryoCloud: 👉 Learn more and book a call: www.cryocloud.io 👉 Sign up directly: app.cryocloud.io/sign-up 👉 Explore the docs: docs.cryocloud.io 📫 hi@cryocloud.io

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CryoCloud @cryocloudio.bsky.social · 08/01/2026

New year, new projects — and often new tools to evaluate. If you’re curious about CryoCloud, there are two simple ways to get started: 🔷 Free academic account 🔷 30-day evaluation trial Links in the comments 👇 #cryoEM #structuralbiology

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CryoCloud @cryocloudio.bsky.social · 24/12/2025

As 2025 comes to an end, thank you to the CryoCloud community. Every conversation, dataset, and piece of feedback helps us build a better platform for structural biology. From all of us at CryoCloud, wishing you a warm, restful holiday season and a great start to 2026. ✨

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CryoCloud @cryocloudio.bsky.social · 23/12/2025

CryoCloud Map of the Month (Holiday Edition 🎄): Alpha‑Synuclein Fibril For December’s edition, we reprocessed EMPIAR‑12229 and generated a 2.3 Å map of the in vitro alpha-synuclein fibril using CryoCloud. 🔬 Dataset size: 5,193 movies 🧠 Compute time: 56.5 hours #CryoEM

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CryoCloud @cryocloudio.bsky.social · 18/12/2025

📩 Want future updates in your inbox? Sign up here: 2dydb3.share-eu1.hsforms.com/2gc1LRqWkRJ6...

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CryoCloud @cryocloudio.bsky.social · 18/12/2025

📢 CryoCloud Newsletter: End-of-Year Edition is out! A huge thank you to our users, collaborators, and the structural biology community for being part of the journey this year 💙 👉 Read it here: connect.cryocloud.io/newsletter-d... #CryoCloud #CryoEM #StructuralBiology #DrugDiscovery

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CryoCloud @cryocloudio.bsky.social · 16/12/2025

🌟 Employee Spotlight: Boy Persoon As Co-Founder and CPO of #CryoCloud, Boy has been the driving force behind turning our ambitious product vision into a functional, user-first platform. If you’ve ever used our platform and thought “this just works” – Boy probably had something to do with it 🍀

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CryoCloud @cryocloudio.bsky.social · 12/12/2025

🚀 CryoCloud v2.18 is live! This release includes two new beta features designed to further automate #cryoEM workflows, along with other improvements. What’s new: 🔹 AutoClass2D – automatically select 2D classes using a reference .mrc file 🔹 Workflow Export & Import lnkd.in/eb8ic_TK #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 09/12/2025

In our benchmarks, MotionCorr CC outperformed Relion’s CPU-based motion correction running on the CryoCloud platform across all detectors, movie sizes, and frame counts.

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CryoCloud @cryocloudio.bsky.social · 09/12/2025

With GPU acceleration, MotionCorr CC delivers: ⚡ Up to 4× faster throughput ⚡ Up to 5,000 movies/hour ⚡ 50–75% lower compute cost ⚡ Full compatibility with downstream polishing & CTF refinement

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CryoCloud @cryocloudio.bsky.social · 09/12/2025

🚨 New blog: GPU-accelerated motion correction Motion correction remains one of the slowest and most costly steps in #cryoEM workflows. So we rebuilt it from scratch. Our new in-house GPU-accelerated CryoCloud Motion Correction is designed for speed, scale and high throughput. lnkd.in/eiJgsYgJ

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CryoCloud @cryocloudio.bsky.social · 05/12/2025

🧠 Six new algorithms added since launch, including CryoCloud Picker and CryoCloud MotionCorr, bringing major improvements in speed and quality ⚡ Automated workflows and rapid development across the entire platform 🔐 ISO 27001-certified processes

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CryoCloud @cryocloudio.bsky.social · 05/12/2025

3 years in numbers: 💻 Over 100,000 GPU hours of data processing 🔬 Thousands of datasets processed across cryo-EM & X-ray 🚀 355 production deploys + 2,158 staging deploys – steady improvements week after week 👥 A growing global user community (hundreds of users including trials)

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CryoCloud @cryocloudio.bsky.social · 05/12/2025

🔥 Three years ago, the CryoCloud platform went live 🎉 Today, scientists from 25+ countries rely on it every day for analysing their structural biology data – and we couldn’t be prouder of how far things have come. Thank you to all our users, collaborators, and early supporters 💙 #CryoEM

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CryoCloud @cryocloudio.bsky.social · 05/12/2025

🚀 CryoCloud v2.17 is live! This release introduces Targets – a new way to organise datasets & projects around your molecule of interest. Targets make it easier to browse results, store reference files in one place and launch automated workflows. connect.cryocloud.io/release-note... #CryoEM

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CryoCloud @cryocloudio.bsky.social · 26/11/2025

November Map of the Month: CDK-activating kinase (CAK), an oncology target bound to the covalent inhibitor THZ1 💊 We reprocessed EMPIAR‑11793 and produced a 2.5 Å map of the ~85 kDa CAK-THZ1 complex using CryoCloud. 🔬 Dataset size: 12,572 movies 🧠 Total compute time: 52 hours #CryoEM #CryoCloud

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CryoCloud @cryocloudio.bsky.social · 21/11/2025

And if you missed the last release... with v2.15, we added three new cool structural-biology tools to the platform – LocScale2, CryoSieve, and EMReady! Catch up here → connect.cryocloud.io/release-note...

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CryoCloud @cryocloudio.bsky.social · 21/11/2025

🚀 CryoCloud v2.16 is live! This release introduces filament support, including filament picking, visualisation, and a new Initial Model job type for helical workflows. Full release notes → connect.cryocloud.io/release-note... #CryoEM #StructuralBiology

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CryoCloud @cryocloudio.bsky.social · 19/11/2025

🌟 Employee Spotlight: Anna Boronina Anna brings a strong mix of ML and software engineering to #CryoCloud. She’s behind our ML-based particle picker, which has expanded since its initial release to include contamination segmentation, models for diverse targets & lightning-fast performance. #cryoEM

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CryoCloud @cryocloudio.bsky.social · 13/11/2025

If you’d like to continue any of the discussions from Basel or take a closer look at the platform, feel free to reach out at hi@cryocloud.io!

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CryoCloud @cryocloudio.bsky.social · 13/11/2025

• Reliable particle picking and QC, such as 2D class selection & map anisotropy, remain central for scaling automated workflows • The bottleneck has shifted from compute → expertise → data management • Structured data & faster feedback loops are essential for routine, high-throughput work

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CryoCloud @cryocloudio.bsky.social · 13/11/2025

Back from a #PSDI2025 in Basel. Lots of good discussions and clear interest in practical ways to handle growing cryo-EM and X-ray data volumes. We shared results from our large-scale automated analysis of 53 EMPIAR datasets (key takeaways in the comment below!) #CryoEM #StructuralBiology

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CryoCloud @cryocloudio.bsky.social · 05/11/2025

We’re heading to #PSDI2025! Meet the CryoCloud team and don’t miss our talks: ⚡ Sun 9 Nov: Towards Automating Cryo-EM Data Analysis 🚀 Tue 11 Nov: Accelerating Data Analysis with CryoCloud Drop by our booth or book a chat 👇 connect.cryocloud.io/meetings/cry... #CryoEM #XrayCrystallography

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CryoCloud @cryocloudio.bsky.social · 28/10/2025

October Map of the Month: GLP-1R With pharma racing to develop next-generation obesity and diabetes drugs, this #GPCR needs no introduction 💊 We reprocessed EMPIAR-10673, showing GLP-1R bound to its natural ligand GLP-1, and achieved a 2.7 Å map on CryoCloud using 40 h of compute. #CryoEM

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CryoCloud @cryocloudio.bsky.social · 24/10/2025

Read more about MotionCorr CC in this post: bsky.app/profile/cryo...

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