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Centre for Programmable Biological Matter

@cpbm-heddlelab.bsky.social
32 followers 5 following 53 posts

At the CPBM, we are interested in understanding, designing and building natural and artificial bionanomachines. Located at Durham University, funded by The Leverhulme Trust and Academy of Medical Sciences.

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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 28/09/2026
🚀 We’re hiring! Join us as Administrator at the Centre for Programmable Biological Matter, @durham.ac.uk Help enable cutting-edge science by providing vital admin support to our fantastic team of researchers. 📅 Apply by 12th Oct! 🔗 durham.taleo.net/careersectio...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 29/05/2026
Our review 'Tools For Building Artificial Biological Nanostructures' is out in ACS Nano! Microscopic machines for sensing & treating disease are no longer just sci-fi. Here, we map a toolkit to engineer DNA, RNA, proteins & lipids as building blocks for nanoscale devices. doi.org/10.1021/acsn...
doi.org
Tools For Building Artificial Biological Nanostructures
Biological nanostructures and nanomachines encompass a wide range of natural assemblies from the smallest prokaryotes to viruses, enzymes, and subcellular compartments. Their capabilities are impressi...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 21/05/2026
Another highlight from Professor Heddle’s Japan visit was meeting researchers from Kyushu University for discussions on exciting research and future collaboration opportunities. Many thanks to Takeshi Mori, Noriho Kamiya, Ryo Kubota, Shigehiro Yoshimura, and Kenji Inaba for the warm welcome.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 20/05/2026
During his travels in Japan, our Director Prof. Heddle visited @aist-jp.bsky.social to speak with top researchers Sumire Fujiwara, Yuji Teramura, Hideki Watanabe, Nobutaka Mitsuda, Masahiko Imashimizu, and Hikaru Suenaga. Many thanks to AIST for the warm welcome and insightful discussions.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 19/05/2026
🧪Bionanotech in Action webinar - May 28th 10:00 BST! Join us for the next instalment of our free-to-attend webinar series, exploring innovative work in biological nanotech by early career researchers. Simply click the link to join and learn! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 18/05/2026
Huge congratulations to our Assistant Professor Ting-Yu Lin on winning the grand prize in the RNA Society 2026 infographic contest! Special thanks to PhD students Ethan Morgan, Yasmin Stone and Yong-Han Su for their contributions. @rnasociety.bsky.social #RNAmodification #ScienceCommunication
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 18/05/2026
Delighted to share that our work, published in Macromolecular Rapid Communications, has ranked within the top 10% of most-viewed papers published by the journal in 2024! onlinelibrary.wiley.com/doi/full/10.... #TopViewedArticle @wiley.com @durham.ac.uk
onlinelibrary.wiley.com
Designed, Programmable Protein Cages Utilizing Diverse Metal Coordination Geometries Show Reversible, pH‐Dependent Assembly
A hyperstable artificial protein cage can be disassembled on demand under specific conditions such as pH below 7. The cage reassembles when conditions are reversed.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 11/05/2026
Today, our Director, Professor Heddle, had the pleasure of visiting Institute of Science Tokyo, for insightful scientific discussions and to explore future collaborations between the CPBM, Durham University, and leading researchers at Institute of Science Tokyo. Thank you for the warm welcome!
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 06/05/2026
We are proud to be funded by @acmedsci.bsky.social. The latest round Professorship Scheme is now open, offering up to £500k to support the work of biomedical and healthcare researchers moving to the UK! Applications close 10th June. acmedsci.ac.uk/grants-and-s...
acmedsci.ac.uk
Academy of Medical Sciences Professorship Scheme
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 28/04/2026
Our latest work with @jagiellonskiuni.bsky.social has been published in Small Structures! We have created a system that combines DNA origami to efficiently capture membrane protein-loaded nanodiscs within a 46 nm DNA origami ring. onlinelibrary.wiley.com/doi/10.1002/... @durham.ac.uk
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 21/04/2026
🧪Bionanotech in Action webinar - April 29th 10:00 BST! Join us for the next instalment of our free-to-attend webinar series, exploring innovative work in biological nanotech by early career researchers. Simply click the link to join and learn! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 15/04/2026
Delighted to share our new publication in Nature Communications! Together with collaborators, we uncover how a key bacterial membrane transporter, SbmA, imports antimicrobial peptides, revealing multiple structural states. www.nature.com/articles/s41... @durham.ac.uk #StructuralBiology
nature.com
Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters - Nature Communications
SbmA is a proton-driven transporter that imports antimicrobial peptides andstructurally resembles the transmembrane domain of ABC-transporters. Here, authors show through cryo-EM structures, EPR spect...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 02/04/2026
Apply for an MSCA Postdoctoral Fellowship at the CPBM, Durham University! We are seeking ambitious researchers with proposals in: - Protein design (plants & human health) - RNA biology Get in touch today - info@heddlelab.org marie-sklodowska-curie-actions.ec.europa.eu/actions/post... #MSCA
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 20/03/2026
Very pleased to share that we have achieved Platinum certification from My Green Lab! 🌿🌍 We’re proud of our team's collective effort to cut waste, save energy & embed sustainability into our research. Let’s keep building a greener future! 🌟 #Sustainability #MyGreenLab @durham.ac.uk
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 23/02/2026
🧪Bionanotech in Action webinar - Feb 25th, 2026 10:00 GMT! Join us for the next instalment of our free-to-attend webinar series, exploring innovative work in biological nanotech by early career researchers. Simply click the link to join and learn! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 09/02/2026
🚀 Exciting PhD opportunity at the CPBM! RNA modification by enzymes is integral to controlling cell stability and survival but not yet understood. Our goal is to change that. Join us by applying to our latest PhD project! 📩 Deadline 27/02/2026 www.findaphd.com/phds/project... #PhD #NEEDL
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 12/12/2025
🚀 Exciting PhD opportunity at the CPBM! The instability of mRNA hinders its use as an industrial therapeutic development platform. Our goal is to change that. Join us on this journey of discovery by applying to our latest PhD project! 📩 Deadline 01/01/2026 www.findaphd.com/phds/project...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 08/12/2025
🚀 New pioneering PhD opportunity! Use AI-driven protein design to develop nanowires capable of communicating with single cells. Join us in transforming single-cell biology and beyond. 📩 Deadline 25/12/2025 findaphd.com/phds/project... #ProteinDesign #PhDopening #CPBM @durham.ac.uk
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Reposted by Centre for Programmable Biological Matter
Academy of Medical Sciences @acmedsci.bsky.social · 27/11/2025
💡 Are you a biomedical or healthcare researcher who has recently moved to the UK and started a Professorship? You could receive up to £500k to power your research through our AMS Professorships scheme! 🚀 Apply by Wed 21 Jan 4pm GMT 👉 Learn more and check full eligibility: bit.ly/4p8cq8v
bit.ly
Academy of Medical Sciences Professorship Scheme
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 09/10/2025
🚂 All aboard for Science! This half-term, the Celebrate Science Festival rolls into Locomotion, Shildon, and we’re thrilled to be part of it! 🧬 Explore biological nanoscience with VR, puzzles & more! 📅 28–29 Oct 2025 | 10 AM–4 PM 👉 Secure your tickets today: locomotion.org.uk/whats-on/cel...
locomotion.org.uk
Celebrate Science | Locomotion
Calling all young scientists! Locomotion is the next stop for the annual festival to celebrate science.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 03/10/2025
🚀 We’re hiring! Join us as Administrator at the Centre for Programmable Biological Matter, Durham University. Help enable cutting-edge science by providing vital admin support to our fantastic team. 📅 Apply by 16th Oct! 🔗 durham.taleo.net/careersectio... #hiring
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 16/09/2025
🌟 We’re hiring an Assistant Professor to join us at the Centre for Programmable Biological Matter @durham-university.bsky.social Lead cutting-edge research, inspire students & turn discoveries into real-world impact. Join us & shape the future! durham.taleo.net/careersectio... #Hiring #JoinUs
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 16/09/2025
🧪Bionanotech in Action webinar - Sept 24th, 2025 10:00 BST! Join us for the next instalment of our free-to-attend webinar series, exploring innovative work in biological nanotech by early career researchers. Simply click the link to join and learn! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 15/08/2025
🚀 New in RNA Biology! Our talented Asst. Professor, Ting-Yu Lin, and PhD Student, Yasmin Stone, have co-authored a fantastic review with Prof. Sebastian Glatt from Malopolska Centre of Biotechnology on how the RNA modification, pseudouridylation (Ψ), shapes RNA structure, stability & function.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 04/07/2025
We are thrilled to share that the work of our Assistant Professor, Dr Ting-Yu Lin, and colleagues at Małopolska Centre of Biotechnology UJ in Krakow and International Institute of Molecular and Cell Biology in Warsaw, has been featured on the cover of this month’s issue of the EMBO Journal!
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 25/06/2025
🚀We are seeking a passionate PDRA/Assistant Professor to join our team in Krakow, Poland! This innovative project aims to develop programmable synthetic nanoparticles with groundbreaking applications in virus capture. Closing date 6th July: euraxess.ec.europa.eu/jobs/345060
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 21/05/2025
🎉 What a fantastic day! A huge thank you to everyone who visited our exhibition yesterday. From VR to puzzles, it was a true celebration of bionanoscience, innovation and discovery. If you missed out this time, be sure keep an eye on our socials for info on upcoming events.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 21/05/2025
🔬 Bionanotech in Action webinar - May 28th, 2025 15:00 BST! Join us for the fifth instalment of our free-to-attend webinar series, exploring innovative work in biological nanotech by early career researchers. Simply click the link on the day to join and learn! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 20/05/2025
Today is the day! 🌟 Come along to our FREE exhibition at the Palace Green Library to learn about the world of bionanoscience. Curated by our researchers, the event will comprise of posters, videos, puzzles, virtual reality & more! Drop in anytime between 10:00AM and 4:00PM.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 13/05/2025
Just one week to go until our free, family-friendly exhibition at the Palace Green Library, Durham! Come along to be inspired and learn about the power of bionanoscience. 💡 🧬 🔬
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 07/05/2025
🧬 Step into the world of bionanoscience! You are invited to join us at our free, family-friendly exhibition on May 20th at Palace Green Library, Durham. 🧩 Puzzles, posters, VR & more 🕙 Drop in anytime 10AM–4PM ✨ Fun, hands-on & inspiring! heddlelab.org/the-stuff-th...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 23/04/2025
🧪 Bionanotech in Action webinar - April 30th, 2025 15:00 GMT Join us for the fourth instalment of our free-to-attend webinar series, exploring the fantastic work of early career researchers in biological nanotech. Just click on the link and learn! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 15/04/2025
🌟 We landed the cover of Macromolecular Rapid Communications! 🌟 A huge thank you to our researchers and collaborators for their hard work and commitment to this research on programmable protein cages. @jagiellonskiuni.bsky.social Credit to Izabela Czernecka for the fantastic artwork.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 21/03/2025
🚨 Bionanotech in Action webinar - March 26, 2025 15:00 GMT! Join us for the third instalment of our new, free-to-attend webinar series, exploring cutting-edge work in biological nanotech by early career researchers! blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 11/03/2025
🚀 We have another fascinating PhD project open for applications! Errors in PUS7 expression can lead to neuron development disorders and cancers, however the regulatory mechanisms of PUS7 remain unclear. Join us to close this important knowledge gap. www.findaphd.com/phds/project...
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Reposted by Centre for Programmable Biological Matter
Adam Bentham @adamrbentham.bsky.social · 28/02/2025
Pls repost 🚨I'm looking for someone excited about #proteindesign and #synbio to join my lab @Durham_Uni at the CPBM @cpbm-heddlelab.bsky.social to undertake a PhD using #synthetic knottins as novel #bioinsecticides. If you're interested please get in touch and check out the advert below 👇
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Reposted by Centre for Programmable Biological Matter
David Doupe @dpdoupe.bsky.social · 10/03/2025
Another exciting PhD opportunity involving some collaborative fly stem cell work. This one is led by Ting-Yu Lin from the @cpbm-heddlelab.bsky.social and will use a range of biochemical and biophysical techniques to explore the function of a critical RNA modifier: www.findaphd.com/phds/project...
findaphd.com
Understanding of RNA pseudouridylation and its impacts in disease at Durham University on FindAPhD.com
PhD Project - Understanding of RNA pseudouridylation and its impacts in disease at Durham University, listed on FindAPhD.com
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 26/02/2025
Excited to announce that our latest research has been published in ACS Nano! This work outlines the controllable assembly of pentamer-based protein cages and nanotubes, with strong applications in drug delivery, catalysis & more. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Dynamic Assembly of Pentamer-Based Protein Nanotubes
Hollow proteinaceous particles are useful nanometric containers for delivery and catalysis. Understanding the molecular mechanisms and the geometrical theory behind the polymorphic protein assemblies ...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 24/02/2025
🚀 Malopolska Centre of Biotechnology are hiring! We’re seeking a passionate PDRA/Assistant Professor to join our team in Krakow, Poland. This innovative project aims to develop programmable synthetic nanoparticles with groundbreaking applications in virus capture. euraxess.ec.europa.eu/jobs/319171
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 24/02/2025
🚨 Bionanotech in Action webinar - Feb 26, 2025 15:00 GMT! 🚨 Join us for the second instalment of our new webinar series, exploring cutting-edge work in biological nanotech by early career researchers! 💻 No registration required – just click & learn: blogs.ed.ac.uk/unanowebinars/
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 22/01/2025
🌟New PhD Opportunity 🌟 Use AI to design nanoscale machines such as protein cages & DNA nanostructures for drug delivery. Combine cutting-edge research with teaching as part of the Durham Doctoral Teaching Fellowship! Apply now 👉 www.findaphd.com/phds/project... #PhDOpportunity #SyntheticBiology
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 16/12/2024
🚀 We are thrilled to share that our latest research has been published in Macromolecular Rapid Communications! 🌟 Our innovative cage designs can reversibly assemble, releasing therapeutic cargo in response to changes in pH commonly associated with some cancers.
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 13/12/2024
🌟 Join the Centre for Programmable Biological Matter as our Lab Technician! 🌟 Passionate about science? Work in cutting-edge labs, gain new skills & contribute to groundbreaking research! 🔬 Apply now!: durham.taleo.net/careersectio...  #Biotech #ScienceJobs #Hiring
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 11/12/2024
🚀 Announcing the 2025 Unano Webinar Series – Bionanotech in Action! 📅 1st webinar: Wednesday January 29th, 3 PM GMT 🎙️ Talks by: Greg Knight @durhamuniversity.bsky.social :De novo proteins for artificial plant immune systems James Dodd @edinburghuni.bsky.social :DNA toxicity to cyanobacteria
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 27/11/2024
🚨 New discovery in the fight against antibiotic resistance! 🚨 Together with our brilliant collaborators, we have captured a new image of DNA gyrase in action using cryo-EM, enhancing our understanding of the vital bacterial enzyme and fluoroquinolone target. www.pnas.org/doi/10.1073/...
pnas.org
Structural basis of chiral wrap and T-segment capture by Escherichia coli DNA gyrase | PNAS
Type II topoisomerase DNA gyrase transduces the energy of ATP hydrolysis into the negative supercoiling of DNA. The postulated catalytic mechanism ...
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Centre for Programmable Biological Matter @cpbm-heddlelab.bsky.social · 26/11/2024
🚀 We’re hiring! 🚀 We are seeking a passionate PDRA to lead an exciting AMS funded project in designing dynamic protein cage-based vaccines. Utilise state-of-the-art biochemistry and deep learning tools to create systems with real-world impact. durham.taleo.net/careersectio...
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