This study describes the complex transcriptional regulatory mechanism enabling fine-tuned and rapid regulation of Plasmodium falciparum investment in transmission under changing blood conditions.

Author summary The most common clinical symptom of malaria is periodic fever. To survive at febrile temperatures, malaria parasites must protect themselves from the damage that these temperatures prod...

To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by increased expression of specific...

Author summary Proper regulation of gene expression is crucial for the functioning of all organisms. One key mechanism involves modifications in the structure of chromatin, the DNA and proteins comple...

In the malaria parasite Plasmodium falciparum, the expression of many genes is regulated by heterochromatin (HC) based on the histone mark tri-methylation of histone H3 lysine 9 (H3K9me3). HC assembly...