Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present during neurodevelopment, using aberrant glutamate receptor stimulation to activate PDGFRα/ERK via Src. This uncovers a molecular link between neurotransmitter signaling and tumor growth in children.

Nature Communications - With the emergence of immune checkpoint inhibitor therapies for cancer, the authors use single-cell sequencing to assess exhausted T cell content in human glioma samples and...