iiinova — where your digital self keeps evolving

Conny WH Yu @connyyu.bsky.social · 09/03/2026

Have you ever looked at a protein structure and wondered... What am I even looking at? To help navigate, I wrote a PyMOL plugin that automatically identifies and labels protein chains. It leverages the 𝗦𝗜𝗙𝗧𝗦 𝗺𝗮𝗽𝗽𝗶𝗻𝗴 (from UniProt and PDBe) to colour and label protein chains by their UniProt IDs.

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Reposted by Conny WH Yu

Lori Passmore @lapassmore.bsky.social · 15/11/2025

This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...

nature.com

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Conny WH Yu @connyyu.bsky.social · 25/06/2025

To me, Mad2 also serves as a reminder that proteins are dynamic and that there is still so much to explore in structural biology. Finally, a huge shoutout to my longtime collaborators Élyse Fischer and David Barford. Thank you both for this MAD journey!

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Conny WH Yu @connyyu.bsky.social · 25/06/2025

A very late repost: Mad2 is an incredible metamorphic protein capable of adopting multiple conformations. Here we reviewed existing structural data and investigated this ever-changing protein using a combination of real-time NMR and MD simulations (kudos to Joe! @jgreener64.bsky.social)

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Reposted by Conny WH Yu

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 27/11/2024

🚨 New from PDBe! Check out the revamped PDBeChem service with enhanced Ligand Pages! 🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place. 👉 Read more in the news: buff.ly/4g8eF6E

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Reposted by Conny WH Yu

Lori Passmore @lapassmore.bsky.social · 21/10/2024

In this work, James used NMR with @connyyu.bsky.social , crosslinking mass spec with the Rappsilber lab and biochemical reconstitution to discover that dispersed regions within the IDRs interact with multiple conserved binding sites on Ccr4-Not.

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Conny WH Yu @connyyu.bsky.social · 16/12/2023

... who know how to make creative use of the surprises that they encounter when they do so. These are the people who make the enduring difference." - Aaron Klug www.nature.com/articles/nrm...

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Conny WH Yu @connyyu.bsky.social · 16/12/2023

"You cannot by sheer force compel scientific truths to reveal themselves. The major insights come only to the individuals who have the patience to develop an intimate understanding of a problem, who have the space and the freedom to take professional risks and explore apparently bizarre ideas...

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