Conny WH Yu @connyyu.bsky.social · 09/03/2026Have you ever looked at a protein structure and wondered... What am I even looking at? To help navigate, I wrote a PyMOL plugin that automatically identifies and labels protein chains. It leverages the 𝗦𝗜𝗙𝗧𝗦 𝗺𝗮𝗽𝗽𝗶𝗻𝗴 (from UniProt and PDBe) to colour and label protein chains by their UniProt IDs. 120
Reposted by Conny WH YuLori Passmore @lapassmore.bsky.social · 15/11/2025This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...nature.com 05014
Conny WH Yu @connyyu.bsky.social · 06/11/2025And it's now live in Nature Structural & Molecular Biology! Many thanks to James and @lapassmore.bsky.social for a great collaboration. www.nature.com/articles/s41...nature.comPhosphorylation-dependent tuning of mRNA deadenylation rates - Nature Structural & Molecular BiologyStowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to t... 160
Conny WH Yu @connyyu.bsky.social · 25/06/2025A very late repost: Mad2 is an incredible metamorphic protein capable of adopting multiple conformations. Here we reviewed existing structural data and investigated this ever-changing protein using a combination of real-time NMR and MD simulations (kudos to Joe! @jgreener64.bsky.social) 162
Reposted by Conny WH YuProtein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 27/11/2024🚨 New from PDBe! Check out the revamped PDBeChem service with enhanced Ligand Pages! 🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place. 👉 Read more in the news: buff.ly/4g8eF6E 0186
Reposted by Conny WH YuAlex Bateman @alexbateman1.bsky.social · 18/11/2024Happy to announce that the latest UniProt NAR paper is now out. Find out what we've been up to here academic.oup.com/nar/advance-...academic.oup.comUniProt: the Universal Protein Knowledgebase in 2025Abstract. The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely acce 16523
Reposted by Conny WH YuLori Passmore @lapassmore.bsky.social · 21/10/2024In this work, James used NMR with @connyyu.bsky.social , crosslinking mass spec with the Rappsilber lab and biochemical reconstitution to discover that dispersed regions within the IDRs interact with multiple conserved binding sites on Ccr4-Not. 122
Conny WH Yu @connyyu.bsky.social · 16/12/2023"You cannot by sheer force compel scientific truths to reveal themselves. The major insights come only to the individuals who have the patience to develop an intimate understanding of a problem, who have the space and the freedom to take professional risks and explore apparently bizarre ideas... 610121