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Colin J Saldanha-Moore

@colinjohnsaldanha.bsky.social
208 followers 124 following 140 posts

Scientist, professor, music, food & sports enthusiast! Steroid synthesis in the brain and its effects on structural and functional neuroplasticity. I don't speak for anybody else, or any institution.

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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 25/04/2025
Neurendo nerds. Join us!!
whova.com
29th Annual Meeting of the Society for Behavioral Neuroendocrinology hosted on Whova
July 13 – 16, 2025, Vancouver, BC
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 30/03/2025
Join us!
partiful.com
RSVP to Sign-Making for Hands Off! | Partiful
Join Uptown Indivisible and friends to make signs in preparation for April 5th's Hands Off! March on DC. We will provide supplies.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 22/03/2025
Thank you @drglitterbear.bsky.social and the Society for Behavioral Neuroendocrinology (SBN).
sbn.org
What Are Transgender Animal Experiments and Why Should We Do Them? | Society for Behavioral Neuroendocrinology (SBN)
The Society for Behavioral Neuroendocrinology (SBN) is an interdisciplinary scientific organization dedicated to the study of hormonal processes and neuroendocrine systems that regulate behavior.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 16/03/2025
www.cbsnews.com/newyork/news...
cbsnews.com
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 15/03/2025
Ugh. Please be safe Columbia peeps.
npr.org
Turmoil rocks Columbia University as Trump administration demands changes — or else
The Trump administration delivered an ultimatum to leaders of Columbia University: Make a series of major changes or lose out on billions in federal aid.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 08/03/2025
I'm drifting in a sea of Ireland fans! They were not happy with what the French did to them today!
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 08/03/2025
Thanks to Cindy for posting! From around 2:10-2:32, that's me behind the band and Bill Nye in my 3XL, hot-pink, PhDiva lab-coat! Cassandra is immediately to my left in her March for Science t-shirt. :).
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 08/03/2025
DC's Stand Up for Science was excellent! Bill Nye the Science Guy was there. The weather was perfect and I swear I was wearing shorts under my fabulous lab-coat!
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 05/03/2025
From the mind and desk of my fantastic colleague Rebecca Calisi. Preach hermana, preach!!
nature.com
‘Silence is complicity’ — universities must fight the anti-DEI crackdown
Higher-education establishments must not be bullied into abandoning their mission of diversity, equity and inclusion.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 04/03/2025
Working from home allows things like this to happen. I made a quiche! A motherfckn quiche. My very first motherfkn quiche!!Low carb crust from scratch and onion, proscuitto, gruyere, swiss, mozzarella and egg whites. I feel victorious!
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 02/03/2025
My amazing wife is on a call with Indivisible. She's organizing a group here in upper NW DC. I could not be prouder! So, I cooked dinner. Cajun catfish with turnip greens and Brussel's sprouts. There was a lot of bacon grease involved!
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Reposted by Colin J Saldanha-Moore
KAMALA NATION @kamalanation.bsky.social · 01/03/2025
Ending the night with this. *Get your hankies* A D-Day veteran called a gracious and humbled Zelenskyy a hero.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 01/03/2025
This is how deep we have sunk. Condescending arrogance much?
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 27/02/2025
Check this out! A Special Issue dedicated to Nicky Clayton. Weekend reading is going to be fun!
link.springer.com
A special issue in honor of the contributions of Professor Nicola S. Clayton FRS - Learning & Behavior
It has been an honor to edit this special issue of Learning & Behavior to recognize the exceptional contributions of Prof. Nicky S. Clayton FRS to the fields of comparative cognition and developmental...
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 26/02/2025
FK! We fkn told you, you fkn fk!!
apnews.com
An unvaccinated child has died in the Texas measles outbreak that's infected more than 120 people
A child who was not vaccinated has died from measles in West Texas. It's the first death in an outbreak that began late last month and the first from measles in the U.S. since 2015.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 24/02/2025
Dinner last night. The ancestors came calling. Chicken Makhani, cabbage, carrots and peas, raita all served with "Right Rice."
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 22/02/2025
There are few things as beautiful as a beer, six nations rugby, fellow sports fans, neighborhood regulars, and Duran Duran on the speakers
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 19/02/2025
Fish tacos make everything better. So do caipirinhas, and notes from dear friends that make you tear up. 🥹
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 18/02/2025
Happening today. Thanks for the invitation.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 16/02/2025
Stress cooking. Boneless ribeye with roasted sprouts, onion, and red potatoes; served with carrot and mushrooms poached in butter. Bordeaux. Turned out OK, but there was definitely room for improvement.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 16/02/2025
Caesar salad with grilled shrimp. Science is the first demonstration that non-human apes can respond to the "state of mind," of a human partner. Bonobos behave differently when their human partner doesn't vs does know where a treat is hidden. They help when the partner doesn't. Link in comments.
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Reposted by Colin J Saldanha-Moore
DrGlitterbear @drglitterbear.bsky.social · 14/02/2025
@sbn-bsky.bsky.social has released a statement on current events. SBN DEI comm, of which I'm chair, wrote this statement to be people-first focused on the human impacts. I want to thank Peg McCarthy & the Exec Comm in quickly approving the document w/ few edits. This is why SBN is my "home" society.
sbn.org
A Statement from the Society for Behavioral Neuroendocrinology on Current Events | Society for Behavioral Neuroendocrinology (SBN)
The Society for Behavioral Neuroendocrinology (SBN) is an interdisciplinary scientific organization dedicated to the study of hormonal processes and neuroendocrine systems that regulate behavior.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 13/02/2025
And another....
statnews.com
Second top NIH official, who oversaw awarding of research grants, departs abruptly
Michael Lauer, deputy director of the National Institutes of Health’s extramural research, will leave the agency at the end of the week.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 12/02/2025
Ouch! Resignation can occur in the context of a job, and in the context of giving up. :(
science.org
Top NIH official suddenly steps down
Lawrence Tabak had served in various roles in director’s office for many years
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 11/02/2025
Phew.
cbsnews.com
Judge orders HHS, CDC and FDA to restore deleted webpages with health information
The NGO Doctors for America argued that HHS, CDC and FDA violated federal law in removing medical information from public-facing websites.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 10/02/2025
From my respected colleague Derek Daniels. He is spot-on correct. I don't know a single scientist who is, "in it for the money." In fact, that idea is laughable. Thank you Derek.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 09/02/2025
I was funded by the NIH (2001-2017), and then served as a Program Director and Expert for NSF (2018-2020). I currently (and fortunately) am funded by the NSF (2021-26). This hurts students, staff, and scientists in the US, and puts China in the driver's seat of intellectual and technical progress.
arstechnica.com
White House budget proposal could shatter the National Science Foundation
“This kind of cut would kill American science and boost China.”…
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 08/02/2025
Music, especially the stage, has always been a comfort in times of tumult. Listen.
youtube.com
"As If We Never Said Goodbye" - Nicole Scherzinger - Sunset Blvd. (LIVE on The Late Show)
YouTube video by The Late Show with Stephen Colbert
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 08/02/2025
This is not going to end well. Lost jobs, slow research, shoddy clinical trials....
science.org
NIH slashes overhead payments for research, sparking outrage
Move to cut indirect cost rate to 15% could cost universities billions of dollars
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 07/02/2025
Another example of how basic science creates tools that can reveal complex physiological phenomena. The machinery that makes fireflies glow is tagged onto specific RNAs. This allow you to see which neurons are transcribing the RNA of interest - like when memories form! Way cool science stuff!
pod.link
Science Friday
Brain fun for curious people.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 04/02/2025
Until recently, I actually respected some republicans. Right now, not so much. We have physicians breaking their Hippocratic Oath (I know, silly me), lawyers supporting blatantly illegal activities (ya, I know, there are whores everywhere). Spineless, weak, selfish, and devoid of principle. Fuck you
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 03/02/2025
In a weekend world of rabid rugby fans, be a Cassandra! The manager couldn't believe she was working. 😀
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 03/02/2025
What my coffee-cup said!
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 01/02/2025
Lovely evening at Chez C&C. Matthew is visiting. Chicken shawarma, hummus, and pickled veggies with pita. A gorgeous night with the moon and venus(?). Stay strong folks. The bastards are all around us.
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Reposted by Colin J Saldanha-Moore
Chise @sailorrooscout.bsky.social · 01/02/2025
The Phase III study has been in The New England Journal of Medicine. Yes, it is PEER-REVIEWED. • www.nejm.org/doi/full/10....
Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing of autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) at the erythroid-specific enhancer region of BCL11A.Ex vivo genome editing for the treatment of SCD

(A) Workflow of ex vivo gene therapy based on hematopoietic stem and progenitor cells (HSPCs). The ex vivo gene therapy involves isolating HSPCs from patients, performing CRISPR gene editing, and subsequently infusing the modified cellular product back to patients after a conditioning regimen.
(B) Genetic mechanisms underlying SCD. Normal hemoglobin A (HbA) consists of two α-globin subunits and two β-globin subunits encoded by HBB. The sickle Hb allele (HbS, also called βS) is an HBB allele where an adenine-to-thymine substitution leads to the replacement of glutamic acid with valine at position 6 in the mature β-globin chain. Under conditions of deoxygenation, tetramers containing two HbS subunits can polymerize and cause erythrocytes to assume a crescent or sickled shape, giving rise to the name of disease.
(C) Targeted genome editing within the BCL11A erythroid enhancer would reduce BCL11A expression in erythroid cells, thereby promoting high-level expression of γ-globin. γ-Globin can substitute for the defective HbS subunit, thus restoring functional tetrameric hemoglobin complexes with α-globin in individuals with SCD.
• https://www.cell.com/the-innovation/fulltext/S2666-6758(24)00057-2
 Duration of Freedom from Severe Vaso-Occlusive Crises and Freedom from Inpatient Hospitalization for Severe Vaso-Occlusive Crises after Exa-cel Infusion.
Changes in Total and Fetal Hemoglobin Levels, the Percentage of F Cells, and the Proportion of Edited BCL11A Alleles in Blood and Bone Marrow after Exa-cel Infusion.
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Reposted by Colin J Saldanha-Moore
Jill BSky @jilles.bsky.social · 01/02/2025
distribute please?
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 30/01/2025
Cooking as therapy. Shrimp and pork meatballs in scallions, fish sauce, soy sauce and sesame oil in a stir fry with lo mein (chickpea pasta), bokchoy, red pepper, ginger and garlic. Sauce was soy, sesame oil, ginger, garlic, lime juice and cornstarch. G'nite y'all. We live to fight another day!
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 29/01/2025
Big sigh....
reuters.com
White House rescinds order that had frozen federal aid, official says
The White House Office of Management and Budget has rescinded a Trump administration directive pausing federal loans, grants and other financial assistance, a White House official said on Wednesday.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 28/01/2025
"A deadline of 17:00 EST (22:00 GMT) has been set. Each agency is told to pause the issuing of new awards as well as the disbursement of funds under existing awards." Many of my colleagues' work will be crippled; including scientific progress, salaries of researchers, technicians, and trainees.
bbc.com
White House pauses federal grants and loans
Democrats warn the move could have "devastating consequences" on programmes that people across the US rely on.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 27/01/2025
Swordfish in a glaze of honey, soy, vegetable oil, ginger, garlic, lime zest and juice. Seared baby bok choy! We can do this y'all.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 27/01/2025
Never forget.
nytimes.com
At Auschwitz, a Solemn Ceremony at a Time of Rising Nationalism
World leaders and a dwindling group of survivors are joining ceremonies to mark the 80th anniversary of the liberation of the Nazi death camp by the Red Army.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 25/01/2025
It just doesn't get better than this!
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 23/01/2025
JFC. No new hiring, travel, meetings, or communication until further notice. That includes Study Sections scheduled for February, June, and October. I have many colleagues who will suffer. Projects will go unfunded/renewed, students and staff will go unpaid.......terrible.
science.org
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 22/01/2025
Oh my.....(deep sigh). So much to unpack here.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 21/01/2025
Barf-worthy.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 20/01/2025
Stay classy Philadelphia.
nbcnews.com
Foul-mouthed fan banned from Eagles home games, fired from job after viral tirade against woman
The Philadelphia fan used crude language Sunday night in a verbal attack on a Green Bay Packers supporter.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 18/01/2025
I know I shouldn't be surprised, but I am deeply disappointed in Sunder Pichai and Tim Cook. Which part of straight, white, men did you not understand???
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 18/01/2025
Salad of friseé with tomatoes, red onion, avocado and cucumber. Easy vinaigrette. The main course was a "Tuscan salmon," cooked in shallot, garlic, sun-dried tomatoes, spinach and cream. Italian red. Stay sane y'all.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 16/01/2025
Goodbye Costa Rica. Got back my melanin and got to hang out with this cutie.
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Colin J Saldanha-Moore @colinjohnsaldanha.bsky.social · 15/01/2025
Remember that the behavior of insurance companies and lawyers is perhaps a more mercenary, actuarial, and predictive evaluation of any situation than anything else. Eg. insurance premiums/climate change and this.
news.bloomberglaw.com
Meta Lawyer Lemley Quits AI Case Citing Zuckerberg 'Descent' (1)
California attorney Mark Lemley dropped Meta Platforms Inc. as a client in a high-profile copyright case because of CEO Mark Zuckerberg’s “descent into toxic masculinity and Neo-Nazi madness,” the Sta...
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