Sign in

Paul Coen

@coenpm.bsky.social
281 followers 1K following 5 posts

Dad | Husband | Aging, Diabetes and Exercise Researcher | Liverpool FC | Weekend Warrior

PostsRepliesMedia
Paul Coen @coenpm.bsky.social · 03/08/2025
Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fat–derived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress. doi.org/10.1038/s414... @AdventHealthMD
doi.org
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications
Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...
2100
Paul Coen @coenpm.bsky.social · 22/07/2025
The Study of Muscle Mobility and Aging (SOMMA) is open for enrollment!! SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults. Learn more about SOMMA: sommaonline.ucsf.edu
050
Paul Coen @coenpm.bsky.social · 19/07/2025
Delighted to share a recent publication from a long standing collaboration with @siobhanmalany.bsky.social, Maddalena Parafati, and their outstanding team at University of Florida. www.cell.com/stem-cell-re... @spacex.extwitter.link @stemcellreports.bsky.social @adventhealth.bsky.social
cell.com
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation en...
171
Paul Coen @coenpm.bsky.social · 21/05/2025
We are recruiting! We have an open position for a Postdoctoral Fellow with the Aging, Exercise and Bioenergetics group at the Translational Research Institute in Orlando, Florida. If you know of an any trainees who might be interested, please let them know! jobs.adventhealth.com/orlando-fl/r...
jobs.adventhealth.com
Jobs | AdventHealth
098
Reposted by Paul Coen
Katsu Funai @katsufunai.bsky.social · 24/04/2025
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
science.org
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
Unlike healthy blood cells, AML cells reverse the ATP synthase reaction to support oxidative metabolism and resist chemotherapy.
0123
Paul Coen @coenpm.bsky.social · 01/04/2025
WTF! Leadership of the National Institute on Aging was apparently “decimated,” with deputy director Amy Kelly and scientific director Luigi Ferrucci— “one of the brightest luminaries in the world in gerontology,” per a source — among those fired. www.splinter.com/bloodbath-at...
splinter.com
'Bloodbath' at NIH and Elsewhere at HHS Begins
Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.
030
Reposted by Paul Coen
Paul Greenhaff @pgreenhaff.bsky.social · 31/03/2025
Clinical and humans physiology to the fore. Think about submitting your work to The Journal of Physiology. doi.org/10.1113/jp28...
doi.org
Here comes the sun: the central role of human and clinical physiology in the era of multi‐omics and inter‐organ crosstalk
Click on the article title to read more.
033