T cells persist in the central nervous system (CNS) and can drive both protection and neurological disease. How these cells are organized in humans and what they recognize is largely unknown. Here, we...

For decades, we have known that women, especially younger women, are disproportionately affected by pain disorders, including irritable bowel syndrome, endometriosis, menstrual migraines, fibromyalgia...

We've been calling it mitochondrial dysfunction for decades. Turns out that term is scientifically meaningless, and it's been holding back progress in understanding how mitochondria actually work. @M...

Orthostatic intolerance is common in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and may worsen daily functioning. Although hypovolemia has been proposed as a contributor, its relatio...

The detection of cytokines, which are key proteins involved in immune system signaling, is of extreme importance for health monitoring. Among the various cytokines, interleukin-6 (IL-6) is particularl...

What is happening in the body during PEM? While the underlying pathomechanism of PEM is still unknown, Dr. David Putrino shares emerging research into the pathophysiology of PEM and what it may tell ...

YouTube video by RTHM Health

The brain evidently can regenerate itself better than previously assumed after injuries or certain autoimmune diseases.

Abdullah MY (9) studied the impact of COVID-19 on cytokines and gene polymorphisms in patients with type 1 diabetes. Machine learning analyses identified IL-...

Neuropsychopharmacology - Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders

Listen to this article Researcher Dr Zack Shan Institution University of the Sunshine Coast, Australia Start date June 2023 Funding ME Research UK with the financial support of the Fred and Joan Davie...

Spinal cord injuries affect an estimated 15 to 20 million people worldwide, often causing lasting impairments in movement, sensation, and independence.

Mayo Clinic researchers have identified a protein that cancer cells use to shut down the body's immune response, a discovery that could help scientists develop new treatments that make cancer immunoth...

Extreme fatigue, a racing pulse, shortness of breath, brain fog, aching joints-the symptoms of long COVID can vary widely, change unpredictably, and be difficult to even recognize as signs of the cond...

In this article, Moon and colleagues demonstrate that brain maturation increases SARS-CoV-2 susceptibility through lipid remodeling. Using hIPSC-derived cerebral organoids at two developmental stages ...

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating chronic disease characterized by physical and mental fatigue, post-exert…

A long COVID study examining, for the first time, energy levels in the brain, found them to be depleted in a large region called the cingulate cortex.

The largest-ever genetic study of fibromyalgia has identified new risk factors, a neurological origin, and potential new treatments for the condition.

FOI results reveal low uptake of NHS England's ME/CFS e-learning modules. Read the findings and the ME Association's comments

FOI results reveal low uptake of NHS England's ME/CFS e-learning modules. Read the findings and the ME Association's comments

Low aerobic capacity in patients with long COVID and ME/CFS is often attributed to physical inactivity. The authors show that long COVID and ME/CFS patients have distinct skeletal muscle changes that ...

An overactive immune response to the Epstein-Barr virus, best known for causing mono, may help drive multiple sclerosis, a new study found.

Researchers have uncovered a surprising culprit behind sleep loss in Alzheimer’s disease: the brain’s own immune cells. In mice with amyloid plaques, overactive microglia triggered inflammation that k...

Abstract. AmyloGram is a computer program that uses n-gram encoding and a random forest classifier to produce a numerical score between 0 and 1 for the predicted amyloidogenicity of a given protein se...

The glymphatic system is a recently discovered brain waste clearance system that is mostly active during sleep and disengaged during wakefulness. Impaired gl...

IntroductionPost-COVID syndrome represents a major global health challenge which is characterized by immune dysregulation, although many aspects of the immun...

López and colleagues review recent evidence of RNA virus persistence and the associated consequences in terms of post-acute sequelae or chronic inflammatory syndromes.

People living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) often use pacing with a heart-rate monitor (HRM) to manage their activity intensities to minimise time spent over thei...

High-intensity exercise triggers a coordinated activation of metabolic, endocrine, and immune pathways, yet the mechanisms integrating these responses…

Griffith researchers have identified a key immune cell dysfunction in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, offering new clues on the condition.

BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling condition with limited treatment options and inadequate healthcare structur