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Reposted by doctor evil woman

Joshua Foust 🪖🎮 @joshuafoust.com · 05/05/2026

The single most defining thing Elon Musk has ever done is killing untold numbers of people by having DOGE illegally raid and disband USAID. Not rickets, not cars, not even the CSAMbot on X. It’s this, and so many media pundits just choose to unsee it.

hsph.harvard.edu

USAID shutdown has led to hundreds of thousands of deaths | Harvard T.H. Chan School of Public Health

The Trump administration’s decision to shut down the U.S. Agency for International Development (USAID) has resulted in hundreds of thousands of deaths from infectious diseases and malnutrition, accord...

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doctor evil woman @cischaser.bsky.social · 05/05/2026

agreed. and my city also does have a decent bus network. it's mostly the politics of viewing our nursing staff as disposable / it contributing to further resentment on the floor.

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doctor evil woman @cischaser.bsky.social · 05/05/2026

too many patients were crying about the parking lot spots being taken up by us ["the physicians and nurses of the hospital"] so they [admin] conceded to them and told the nursing staff that they could get bused in [yellow bus, too] instead of driving in. lol.

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doctor evil woman @cischaser.bsky.social · 05/05/2026

idk how monogamous people exist they must want to kill themselves

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doctor evil woman @cischaser.bsky.social · 05/05/2026

my bf's wife holding him down while i punch him in the stomach or fuck him >>>>>

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doctor evil woman @cischaser.bsky.social · 05/05/2026

literally, a better world is possible, the political will must simply exist between systems and peoples

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doctor evil woman @cischaser.bsky.social · 05/05/2026

finding out that there used to be a now-extinct dog breed [canis vertigus] whose sole purpose in life and creation as a breed was to turn meat on a spit via a wooden wheel for british people... evil horrible island

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doctor evil woman @cischaser.bsky.social · 04/05/2026

tl;dr it's probably not as significant as people think and it's very normal to have spontaneous breast growth in 5 years into HRT. i went from a C cup to an E cup on years 5-9 of HRT. nothing changed in what i was doing, and i have never smoked or vaped. i wouldn't smoke or vape mostly b/c it's Bad.

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doctor evil woman @cischaser.bsky.social · 04/05/2026

people who smoke & vape have similar depletion of vitamin C, in example, and is also an essential co-factor for collagen biosynthesis. collagen is a critical structural component of our breast tissue, with the stroma of the breast. smoking obliterates folate, b6, b12, calcium, and vitamin D levels.

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doctor evil woman @cischaser.bsky.social · 04/05/2026

so, can't really say how much vaping influences breast growth. what is true, however, is that smoking and vaping cause nutritional deficiencies / depletion in multiple micronutrients. people who vape and smoke have also poorer overall diets, and weigh ~8-12 lbs less than non-smokers similar to them.

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doctor evil woman @cischaser.bsky.social · 04/05/2026

and, the capacity of nicotine to interfere w/ the estrogen receptor is not really elucidated in literature, but we know it happens because of bone density changes, hot flashes, urogenital symptoms, and lipid metabolism worsening, specific to how estrogen influences those. vaping does it less worse.

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doctor evil woman @cischaser.bsky.social · 04/05/2026

nicotine can also reduce the capacity to do SHBG-binding in the body, through the same mechanism of the liver. it is dose-dependant in all of the circumstances, so people who are smoking a cigarette or three won't really notice much. if you're doing a pack a day, though, very much so.

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doctor evil woman @cischaser.bsky.social · 04/05/2026

it's a 50% reduction in circulating estradiol in people who are smoking 15+ cigs a day- the 2-hydroxylation activity is ~53% higher in smokers smoking such versus ~35% in non-smokers. what nicotine [and cotinine, the metabolite of nicotine] does, is interfere with estrogen receptor signalling.

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doctor evil woman @cischaser.bsky.social · 04/05/2026

it is not nicotine per-say but the induction of CYP1A1 and CYP1A2 from polycyclic aromatic hydrocarbons in combusting tobacco. the increased hydroxylation of estrogen in the liver creates 2-hydroxyestrogen, which is cleared much quicker in circulation and of which has minimal estrogenic activity.

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doctor evil woman @cischaser.bsky.social · 26/04/2026

i love the weird unwell cranks of this site

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Reposted by doctor evil woman

Katie Tightpussy, Editor-In-Chief @katie.bzky.team · 27/02/2026

[trans woman sex worker posting an explicit photo] like what you see? 😘 new video on all the usual places 😇💞 [guy who doesn't know that he is going to transition within three years] you are so Beautiful. i am in awe of your courage and bravery every day that you can be your true self thank you xoxo

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doctor evil woman @cischaser.bsky.social · 19/01/2026

here in north america whether you're here in canada or in the US, basically all of our insulin comes out of north carolina. france, germany, mexico, and india are the other large places of manufacturing and insulin exports. the US government would also just nationalize any problematic corporation.

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Reposted by doctor evil woman

Valerie Smith @valeriejeansmith.bsky.social · 19/01/2026

I attended a Border Patrol recruitment event. By never saying “no,” I was corralled from standing near the recruitment table to having a completed application submitted on my behalf, and I received a tentative selection days later. www.cltampa.com/news/at-st-p...

cltampa.com

At St. Pete recruitment event, Border Patrol rep touts qualified immunity and early retirement

A DHS officer at The Hilton in St. Petersburg, Florida Jan. 13, 2026. Dubbed “The Green Monster” by some DHS officials, Border Patrol has a reputation as

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doctor evil woman @cischaser.bsky.social · 03/10/2025

"you should do your job and ban people spreading hate speech against a heavily politically persecuted minority group" =/= "harassment" lol. you're being asked to do your job and you're having a meltdown over it all over the site. it's honestly pretty embarrassing.

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doctor evil woman @cischaser.bsky.social · 11/06/2025

honestly insane at what an enormous fucking coward the new CEO is. hurrr durrrrr "the pendulum is swinging back in a way we didn't expect"- buddy, YOU are that pendulum swinging back! YOU'RE contributing to it! you're part of the problem! by caving, YOU are moving the needle towards the right!

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Reposted by doctor evil woman

CJ Ciaramella @cjciaramella.bsky.social · 10/03/2025

Congrats to Utah dentists on their new boats

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doctor evil woman @cischaser.bsky.social · 03/12/2024

it is one of the few medications out there which are common enough and capable of causing oral birth control to fail, which is why i historically have cautioned british trans men about such, because many british people DIY it for ADHD.

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doctor evil woman @cischaser.bsky.social · 03/12/2024

and yes it'll potentate oral progesterone. which you may not want, depending on how sensitive you are to it / its metabolite allopregnanolone.

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doctor evil woman @cischaser.bsky.social · 03/12/2024

it is a CYP2C19 inhibitor [see the two images] and an inducer of CYP1A2 / CYP3A4- so it'll reduce concentrations and length for oral estrogen, in example. but also like, dozens of medications in general.

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doctor evil woman @cischaser.bsky.social · 03/12/2024

i would also be aware / careful of the fact that ar/modafinil interacts with quite literally a trillion things

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doctor evil woman @cischaser.bsky.social · 01/12/2024

"can you write "vote 💔" in my super ultra latte quintuple cream mega coconut vegan chocolate fake french word drink thingy. also i will be tipping 47 cents"

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doctor evil woman @cischaser.bsky.social · 01/12/2024

is the milk safe? there's nothing really special to it- and it depends on the pharmacological agents present in the individual, to their milk-to-plasma ratio. cocaine can pass through breast milk, in example. this will harm a baby. domperidone, though? it's fine. pubmed.ncbi.nlm.nih.gov/37352416/

pubmed.ncbi.nlm.nih.gov

The Transfer of Domperidone into Human Milk Remains Low at High Doses - PubMed

Domperidone is a dopamine-2 (D2) receptor antagonist that stimulates the release of stored prolactin in the anterior pituitary. It is prescribed off-label in Canada and Australia to promote lactation ...

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doctor evil woman @cischaser.bsky.social · 01/12/2024

in example: a common way of inducing lactation in women is through a gut motility agent called domperidone. domperidone does not cross the blood-brain barrier, but antagonizes dopamine receptors in our gut, to increase gastric emptying. when the body detects this- it nevertheless raises prolactin.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

for the same reason people in general can and will lactate from antipsychotics, calcium channel blockers, protease inhibitors, or even opioids / cocaine. lactation happens -after- pregnancy*, not -during- it. after progesterone levels drop, a dopamine-prolactin circuit triggers; you lactate.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

but anyways i don't want to spam you with a trillion replies on this thought / bsky [and twitter] are unfortunately a bad format for this kind of information sharing. hopefully i have been useful / educational.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

especially important to mention w/ this in mind is that there's just really not really any case reports of adverse events involving this combo [and drug poisonings / accidents happen all of the time] that i can find, which is highly suspect, as there's always case reports for this kind of stuff.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

given the earliest example i can find of "poppers and viagra kills you" is out of SF in the 1990s, i suspect the belief is either due an incorrect assumption of their mechanisms OR some sort of protestantism finger wagging meant to scare gay men out of fucking, esp due to the article's language.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

b/c, clearly only a would-be rapist would possess such a dangerous drug w/ no recreational uses, even though it has plenty of recreational uses. gay men as they exist [likewise trans women such as myself] are already held under immense suspicion of being sexual deviants / would-be criminals, too.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

it benefits several political purposes though; it perpetuates the belief that assault is done by strangers instead of by people we know and trust, AND it adds a substance with prominent use by gay men / queer people / minorities to a schedule, heavily criminalizing it under the former belief.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

good example is GHB. GHB is common to see recreationally in MSM. all you hear w/ GHB though is that it's used to "spike" drinks / is used for date rape. this is an urban legend like fentanyl in weed / hasn't been validated in literature. most assault is acquaintance-related, and via alcohol.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

part of harm reduction for me is communicating accurate information, basically- it doesn't help that poppers historically have been maligned in medicine due to stuff involving gay men's sexuality and HIV/AIDS, that ends up seeming more on the side of homophobic propaganda than scientific inquiry.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

i'd be negligent if i were to claim something were safe when it was not. but, it's not dangerous. meanwhile, things like cocaine [and its metabolite, cocaethlyene,] which people do not hold to the same PSA, is dramatically worse for one's heart than it- but people are nevertheless okay, to averages.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

yes, the increased risk observed is a confounder specific to this population and why specifically they're being prescribed these medications- for angina, and the underlying issues which causes angina. they are not suddenly dying as is claimed in the original tweet. it's important context.

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doctor evil woman @cischaser.bsky.social · 01/12/2024

god, we prescribe stuff like docusate sodium for constipation even though it has not been found to be different to placebo. there's a journal i like w/ Choosing Wisely called Things We Do For No Reason about the many things we do w/o evidence. shmpublications.onlinelibrary.wiley.com/action/doSea...

shmpublications.onlinelibrary.wiley.com

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