Canfora, Escosio, et al. use an age-stratified transmission model fitted to Portuguese COVID-19 hospitalization and seroprevalence data to assess the impact of school closures before mass vaccination....

Background Vaccination programs have greatly reduced the burden of infectious diseases, particularly in childhood. As populations age, however, the burden of respiratory infections such as influenza A...

Roostaei et al. define cell-type- and state-specific transcriptional programs associated with immune dysregulation in multiple sclerosis. Integrating purified immune cell transcriptomics, network anal...

Author summary After an influenza infection, antibodies provide strong protection—but only against the same strain. Because influenza rapidly mutates its surface proteins, this protection soon becomes...

Schools are important settings for respiratory virus transmission and a major focus of pandemic control measures in the absence of effective pharmaceutical interventions. During the COVID-19 pandemic,...

Advancing Biomedical Research with Stan

Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains...

Tissue-resident memory T cells (TRM) protect from repeated infections within organs and barrier sites. The breadth and duration of such protection is defined at minimum by three quantities; the rate a...

The quality and longevity of CD4+ effector and central memory T cells change with age in mice. This study shows that these cells have longer lifespans and become more quiescent when the organism ages,...

The eradication of the viral reservoir represents the major obstacle to the development of a clinical cure for established HIV-1 infection. Here, we demonstrate that the administration of Anktiva (N-8...

Author summary Households are a main setting for transmission of respiratory viruses. Here, we analyse data from a prospective household study to estimate the time-dependent hazards of introduction of...

This post is about me trying to contribute some code to the Stan codebase. My colleagues and I often use the Dirichlet-Multinomial distri...