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Christophe Stove

@christophestove.bsky.social
99 followers 60 following 30 posts

Prof Toxicology @ Ghent University

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Christophe Stove @christophestove.bsky.social · 12/09/2025
Piece in The Economist on 'nitazenes' - their emergence, current presence, and on what may be next. ▪️With referral to our 2021 publication (pubs.acs.org/doi/10.1021/...), reporting the high opioid activity of the isotonitazene metabolite N-Desethyl isotonitazene ▪️With quotes by Marthe Vandeputte 👇
pubs.acs.org
Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of “Nitazene” 2-Benzylbenzimidazole Synthetic Opioids
Several 2-benzylbenzimidazole opioids (also referred to as “nitazenes”) recently emerged on the illicit market. The most frequently encountered member, isotonitazene, has been identified in multiple f...
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Karen Blakey @karenblakey.bsky.social · 04/09/2025
Have known so many people opposed to the idea of drug checking who, after learning more about it, see that it's about reducing harm. Listening to experts, learning new things, seeing different perspectives. Brisbane drug checking return paused for now. www.abc.net.au/news/2025-09...
abc.net.au
Drug checking service won't reopen as planned after government threats
The Queensland government had threatened to shut down the service, saying it would either "legislate or regulate" to stop drug checking.
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Christophe Stove @christophestove.bsky.social · 06/09/2025
Following up on a 1st part on China’s new generic ban on nitazene analogues, #TalkingDrugs now has a 2nd part out, exploring what to expect and how this ban may play out in the coming years: Will China’s Nitazenes Ban Work? (incl. interview w. Marthe Vandeputte) www.talkingdrugs.org/will-chinas-...
talkingdrugs.org
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Christophe Stove @christophestove.bsky.social · 06/09/2025
Recently out in #ClinChem & worth a read: Watanabe and colleagues, "In Vitro Metabolic Profiling of 18 Semi-Synthetic Cannabinoids—Hexahydrocannabinol (HHC) and Its Analogs—with Identification in an Authentic Hexahydrocannabiphorol (HHCP) Urine Sample" academic.oup.com/clinchem/adv...
academic.oup.com
In Vitro Metabolic Profiling of 18 Semi-Synthetic Cannabinoids—Hexahydrocannabinol (HHC) and Its Analogs—with Identification in an Authentic Hexahydrocannabiphorol (HHCP) Urine Sample
AbstractBackground. Hexahydrocannabinol (HHC) and its analogs are recent additions to semi-synthetic cannabinoids in the recreational drug market. Here, th
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Christophe Stove @christophestove.bsky.social · 07/08/2025
A lot of hard work went into this 🔑 publication from Axelle Timmerman's PhD: Setup and Evaluation of the TRACT Assay Principle for the In Vitro Functional Characterization of Modulators of the Serotonin Transporter and the Serotonin 2A Receptor 👏👏 Now out in Anal. Chem.: pubs.acs.org/doi/10.1021/...
pubs.acs.org
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Christophe Stove @christophestove.bsky.social · 30/06/2025
As of July 1st there's a 'nitazene ban' in China. Based on previous bans (fentanyls & synth cannabinoids), a large impact is expected on the NPS drug market. Move to: ❓️India / elsewhere ❓️ban-evading nitazenes ❓️other / new classes (e.g. 'orphines') ❓️precursors ❓️... english.scio.gov.cn/m/pressroom/...
english.scio.gov.cn
China maintains tough stance on narcotics, targeting psychoactive drugs
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Unsplintering.bsky.social @unsplintering.bsky.social · 15/06/2025
Nitazenes, a synthetic opioid with similar effects to heroin or fentanyl - but much deadlier in potency, have entered Birmingham’s drug supply, causing a crisis with hundreds of overdoses www.youtube.com/watch?v=nbvm...
youtube.com
Nitazenes: The synthetic opioid you've never heard of killing Brits
YouTube video by PoliticsJOE
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CGTN @www.cgtn.com · 20/06/2025
China's anti-narcotics authorities have added nitazenes and 12 other psychoactive substances to the country's list of controlled drugs following the emergence of new alternatives to nitazenes and imidates, and after 46 new psychotropic substances were scheduled last July.
news.cgtn.com
China adds new substances to drug control list
China's anti-narcotics authorities have added nitazenes and 12 other psychoactive substances to the country's list of controlled drugs following the emergence of new alternatives to nitazenes and imid...
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Eric Szeto @ericszeto.bsky.social · 23/06/2025
We tracked how a synthetic opioid 40x more powerful than fentanyl is smuggled into Canada. With open-source support from investigators at @bellingcat.com we found hundreds of ads for nitazenes posted online. Within minutes of responding to the ads, we were talking to criminals. tiny.cc/n6rn001
youtube.com
Worse than fentanyl: How smugglers get a new, deadly drug into Canada
YouTube video by CBC News
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Canada Healthwatch 🍁 @canadahealthwatch.ca · 20/06/2025
Deadly opioid 40 times more powerful than fentanyl smuggled into Canada inside PlayStations, basketballs www.cbc.ca/news/canada/nitazene-onl… 𝗠𝗼𝗿𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗻𝗲𝘄𝘀 ⇢ CanadaHealthwatch.ca
A composite image shows one method a drug seller told CBC News they could conceal nitazines in a teapot, as well as an online ad advertising a type of nitazene on LinkedIn.
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Christophe Stove @christophestove.bsky.social · 16/06/2025
Four potent synthetic opioids are now under international control: 1. N-pyrrolidino protonitazene 2. N-pyrrolidino metonitazene 3. Etonitazepipne 4. N-desethyl isotonitazene Controls took effect 9 June. Read more here (#UNODC Forensic Services): bit.ly/4e25Ifk
bit.ly
News: June 2025 - UNODC: CND decision on international control of four nitazenes enters into force
Portal of the UNODC ICE Programme
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Christophe Stove @christophestove.bsky.social · 08/06/2025
Final published version of "LC-MS/MS-based determination of 25-hydroxyvitamin D in dried blood spots: crucial importance of combining a robust extraction with knowledge of the hematocrit", by Liesl Heughebaert, is now available! 📃 50 days free access via authors.elsevier.com/a/1lE92lYftMvY
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Christophe Stove @christophestove.bsky.social · 21/05/2025
Accepted in #AnalyticaChimicaActa: L. Heughebaert et al., "LC-MS/MS-based determination of 25-hydroxyvitamin D in dried blood spots: crucial importance of combining a robust extraction with knowledge of the hematocrit". A challenging but successful endeavor. 🙌 👏 www.sciencedirect.com/science/arti...
sciencedirect.com
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Christophe Stove @christophestove.bsky.social · 18/04/2025
Navigating nitazenes: A pharmacological and toxicological overview of new synthetic opioids with a 2-benzylbenzimidazole core" by Marthe Vandeputte now out in #Neuropharmacology. Quoting one of the reviewers: "a go-to for pharmacologists studying these drugs". www.sciencedirect.com/science/arti...
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Geekoo @handle.invalid · 11/05/2025
A new pocket-sized device can instantly detect deadly street drugs like nitazenes—offering a breakthrough in overdose prevention. #HarmReduction #DrugSafety #PublicHealthTech
geekoo.news
Instant Test Device Could Revolutionize Street Drug Safety
A new handheld device developed at the University of Bath can instantly detect toxic synthetic opioids in street drugs, offering a powerful tool for harm reduction and overdose prevention.
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Guy Jones @ukguyjones.bsky.social · 08/05/2025
Similar to an ultraviolet spectrometer, it allows drugs to be tested cheaply and at volume. The rapid analysis reveals the contents of a mix and the concentration of some ingredients. #nitazene #SCRA #UVFluorescence #spectroscopy #openaccess www.bath.ac.uk/announcement...
bath.ac.uk
Groundbreaking device instantly detects dangerous street drugs, offering hope for harm reduction
A portable device that detects illicit street drugs on the spot and at very low concentrations, highlighting the dangers they pose, has been developed at Bath.
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Christophe Stove @christophestove.bsky.social · 18/04/2025
Navigating nitazenes: A pharmacological and toxicological overview of new synthetic opioids with a 2-benzylbenzimidazole core" by Marthe Vandeputte now out in #Neuropharmacology. Quoting one of the reviewers: "a go-to for pharmacologists studying these drugs". www.sciencedirect.com/science/arti...
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Christophe Stove @christophestove.bsky.social · 05/04/2025
Van 30 mei - 1 juni vindt in Hulst het festival #VESTROCK plaats. Op VESTROCK UNIVERSITY zal ik, net als andere UGent’ers (Ernst Koster, Nele Vandersickel en Tijl De Bie), een bijdrage leveren. No worries: geen zang, wel een lezing mbt toxicologie 😉. www.ugent.be/nl/actueel/u...
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Christophe Stove @christophestove.bsky.social · 05/04/2025
In today's noon poster session at #ASPET2025: "Nitazenes of the past, present and future: insights from in vitro mu-opioid receptor assays and in vivo behavioral assays in mice." Based on work by Marthe Vandeputte, 🤝 w. DDRU @ NIH, Cayman Chemical, I. Ujvary. 📃: www.sciencedirect.com/science/arti...
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Christophe Stove @christophestove.bsky.social · 03/04/2025
Happy to have arrived in #Oregon for my 1st #ASPET meeting (there's a first for everything 😉). Thanks to the @britpharmsoc.bsky.social for inviting me & looking fwd to co-chairing (& presenting at) the Fri 4/4 15:30 session on clinical pharmacology for treatment optimization. #ASPET2025
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Christophe Stove @christophestove.bsky.social · 03/04/2025
Interesting visit to the Office of the Chief Medical Examiner of San Francisco earlier today. Truly impressive. Thanks good colleague & friend Luke Rodda (& team!) for the kind hospitality!
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Christophe Stove @christophestove.bsky.social · 01/04/2025
(Re)submitted a research project to the Fund for Scientific Research, #FWO @fwovlaanderen.bsky.social, from high in the sky - above Canada - on my way to San Francisco & Portland (#ASPET). 🙌 to my postdoc Marthe Vandeputte for taking the lead in writing! Let's hope it'll be warmly received 😉. 🤞🤞🤞
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Christophe Stove @christophestove.bsky.social · 25/03/2025
Just published in Alcohol Clin Exp Res & now open access available: Jensen et al., "Blood phosphatidylethanol measurements indicate GLP-1 receptor stimulation causes delayed decreases in alcohol consumption". onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Blood phosphatidylethanol measurements indicate GLP‐1 receptor stimulation causes delayed decreases in alcohol consumption
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are effective for treating obesity (BMI ≥30) and are being investigated as a novel treatment for alcohol use disorder (AUD). This secondary analys...
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Christophe Stove @christophestove.bsky.social · 25/03/2025
Amine Larabi & Sarah Wille, Presidents of the #SFTA and #BLT, respectively, opening the joint SFTA-BLT scientific meeting "aux pieds du Mont Blanc", in Chamonix. @sfta.bsky.social
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Christophe Stove @christophestove.bsky.social · 20/03/2025
And the #ResearchDay2025 #ugent was also the moment when prizes for the best PhD of 2024 of the respective Faculties were awarded. Proud that Marthe Vandeputte was the recipient of the PhD Thesis Prize from the Faculty of Pharmaceutical Sciences! 👏👏👏
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UGent faculteit Geneeskunde en Gezondheidswetenschappen @ugent-fge.bsky.social · 20/03/2025
🌟Vandaag vindt onze Research Day plaats samen met de faculteiten Diergeneeskunde en Farmaceutische Wetenschappen. Nog tot 17u ben je welkom op Campus Merelbeke voor een boeiende dag vol kennisdeling! Zien we jou daar? 👋 #ResearchDay2025
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Christophe Stove @christophestove.bsky.social · 20/03/2025
Hans Nauwynck enthusiastically opening the @ugent #ResearchDay2025, a joint initiative of the Fac. of Veterinary Sciences (this year's host), Fac. of Medicine and Health Sciences, and Fac. of Pharmaceutical Sciences. Up to a day of #ugent research & networking!
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Christophe Stove @christophestove.bsky.social · 21/02/2025
In Torino for the PhD defense of Christina Ververi (on microsampling applications in toxicology) & to provide a lecture on "Dried blood microsamples in toxicology & therapeutic drug monitoring: applications & automation". Good to meet with TIAFT colleagues Alberto Salomone (promotor) & Luca Morini!
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Christophe Stove @christophestove.bsky.social · 19/02/2025
Latest publ: Marie Deventer et al., "Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo-Pyridyl Synthetic Cannabinoid Receptor Agonist CH-FUBBMPDORA". #openaccess in DTA: analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10....
analyticalsciencejournals.onlinelibrary.wiley.com
Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA
Another Chinese generic ban-evading SCRA, CH-FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its c...
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Christophe Stove @christophestove.bsky.social · 19/02/2025
VIENNA, Austria – 4 February 2025: The UNODC Early Warning Advisory on New Psychoactive Substances has evidence of the emergence of nitazenes on a global scale. At this point in time, there are strong signals for a further spread of this group of synthetic opioids. 👇 www.unodc.org/LSS/Announce...
unodc.org
News: February 2025 – UNODC EWA: Increasing availability of nitazenes calls for global response
Portal of the UNODC ICE Programme
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Christophe Stove @christophestove.bsky.social · 15/02/2025
"Most nitazene cases reviewed involved hospitalization, had high naloxone dosing, and relatively long LOS. Differences in naloxone dose and hospital length of stay could underscore the unpredictable and potent nature of these substances." 👇 link.springer.com/article/10.1...
link.springer.com
Naloxone Dosing and Hospitalization for Nitazene Overdose: A Scoping Review - Journal of Medical Toxicology
Introduction Nitazene compounds are high potency, synthetic opioids, recently detected in the United States illicit opioid supply. This is a scoping review to summarize the available body of literatur...
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Christophe Stove @christophestove.bsky.social · 11/02/2025
Must admit that I do like all-weather-bike-to-the-lab-rides ❄️❄️❄️
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Christophe Stove @christophestove.bsky.social · 05/02/2025
"We are in a Constitutional crisis whether we like it or not, the worst of my own lifetime by far, and the more voices that are raised against it all, the better. That's what we can do for now. If it gets worse, it gets worse, and we'll revisit the topic, God help us." 👇
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Christophe Stove @christophestove.bsky.social · 05/02/2025
"If anything is forbidden now, it is that medical and science journals, whose duty is to stand for integrity and equity, should bow to political or ideological censorship." 👇
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Christophe Stove @christophestove.bsky.social · 02/02/2025
"Trump and the tech bros: demagogues of harm to human and planetary health" - Editorial in the #BMJ: www.bmj.com/content/388/...
bmj.com
Trump and the tech bros: demagogues of harm to human and planetary health
A US medical society has written to tell us that some of its members will be unable to contribute to journal activities. This followed a government mandate that initially seemed to prohibit US federal...
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Hannah Harris Green @whatsitlike.me · 23/01/2025
A new study from Australia has confirmed that people who’ve ingested nitazenes are often unaware of it, and that naloxone is effective for reversing overdoses involving nitazenes onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Clinical toxicity of nitazene detections in two Australian emergency department toxicosurveillance systems
Introduction Nitazenes are a group of potent synthetic opioids that have had increasing prominence as novel psychoactive drugs in the last 5 years. We describe emergency department nitazene-related ...
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Bellingcat @bellingcat.com · 20/01/2025
You can find our partner Postimees reporting on this issue here: news.postimees.ee/8175100/nita...
news.postimees.ee
NITAZENES ⟩ Estonia's Battle with Deadly Synthetic Opioids Reveals Global Drug Trade Links to China
On December 7, 2023, police responded to a domestic violence call at an apartment in the Kopli district of Tallinn, the capital of Estonia. Upon arrival, they identified a man in his 30s, Sergei, and ...
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Christophe Stove @christophestove.bsky.social · 23/01/2025
Interesting investigative journalism on the evolving #nitazene market (with confirmed links to China) from @bellingcat.com & Postimees 👇.
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Partnership for Clean Competition @pccantidoping.bsky.social · 03/01/2025
Bioassays could be used to detect the biological effects of doping substances, regardless of their chemical structure. This review examines research on activity-based assays to detect doping substances, including strengths & limitations of this approach. 🚫💊 www.sciencedirect.com/science/arti...
sciencedirect.com
Review on activity-based detection of doping substances and growth promotors in biological matrices: do bioassays deserve a place in control programs?
Control programs such as anti-doping control and growth promotor residue surveillance programs are challenged by the emergence of designer drugs and t…
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Christophe Stove @christophestove.bsky.social · 24/12/2024
Wishing you a year filled with kindness and glassatleasthalffullness 🥂! Best wishes for a prosperous 2025 from the Team of the #UGent #UGent_Pharma Laboratory of Toxicology!
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Jan Broder Engler @jbengler.de · 16/12/2024
Stunning free #science vector art for your next poster, paper or talk 🤩 The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes bioart.niaid.nih.gov #rstats #dataviz #phd #illustration
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MANDRAKE @mandrakelab.bsky.social · 19/12/2024
⚠️WARNING!⚠️ 19 Dec 2024 Following testing by our scientists, a #harmreduction #warning, has been issued by #Greater #Manchester Drugs Early Warning System Important #medical & #welfare guidance for #nitazene #intoxication Stay safe and if unwell please seek medical attention
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Grant Glatfelter @gcglatfelter.bsky.social · 18/11/2024
Check out our new publication on the pharmacological characterization of novel, "prophetic" nitazene synthetic #opioids - some of which were found to be more potent than #fentanyl! www.sciencedirect.com/science/arti...
sciencedirect.com
Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice
2-Benzylbenzimidazole derivatives or ‘nitazenes’ are increasingly present on the recreational drug market. Here, we report the synthesis and pharmacol…
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Grant Glatfelter @gcglatfelter.bsky.social · 05/12/2024
New pub in ACSChemNeurosci comparing 5-HT1A & 5-HT2A activities & target profiles of #5MeODMT analogs Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans. pubs.acs.org/doi/full/10....
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Hannah Harris Green @whatsitlike.me · 19/11/2024
By the way, nitazene test strips work! This recent study came back with no false negatives. Encourage your local harm reduction and public health orgs to distribute nitazene test strips! pubmed.ncbi.nlm.nih.gov/39198843/ 🧪
pubmed.ncbi.nlm.nih.gov
Nitazene test strips: a laboratory evaluation - PubMed
This study provides a better understanding of the potential of NTS for drug checking purposes. Our findings indicate that NTS can theoretically alert to the presence of most nitazene analogues that ha...
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Wim Meijer @wimgmeijer.bsky.social · 24/11/2024
China is a source of nitazenes. pharmaceutical-journal.com/article/feat...
pharmaceutical-journal.com
Everything you need to know about nitazenes
The pool of people at risk of overdose from a new type of super-strength synthetic opioid is widening. Once linked to contaminated batches of heroin, nitazenes are increasingly being found in counterf...
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Hannah Harris Green @whatsitlike.me · 18/11/2024
If you're unfamiliar with the term "nitazenes," now is a good time to learn. They're a new class of synthetic opioid that can be up to 40x more potent than fentanyl. In Chicago last month, 7 people in were hospitalized in a single day due to nitazene overdoses. Thread 🧪
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judithyates.bsky.social @judithyates.bsky.social · 03/12/2024
12 examples of "nitazenes" sent to WEDINOS.org from all over the UK in last 3 months (123 examples in 2024 so far). Intended purchase was usually Diazepam, Oxycodone or Heroin. Most recent person however had intended to buy the nitazene. I just hope they know it's hard to judge a non-fatal dose.
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