christianfruiz.bsky.social @christianfruiz.bsky.social · 29/04/2026How does diet causally influence tumor development? Fat composition — not amount — rewires the pancreatic lipidome to control ferroptosis sensitivity and tumorigenesis. Grateful to all collaborators and excited to build on this. 022
christianfruiz.bsky.social @christianfruiz.bsky.social · 16/07/2025🎉 So proud of my wife Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed! 🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection. www.science.org/doi/10.1126/...science.orgSystemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancerA cell-penetrating and RNA binding antibody forms noncovalent complexes with an immunogenic RNA to target tumors and achieve antitumor efficacy. 041
Reposted by @christianfruiz.bsky.socialMuzumdar Lab @muzumdarlab.bsky.social · 15/07/2025Way to go, @xiangyuge.bsky.social, for a fantastic talk on how #PI3K governs resistance to #KRAS inhibition in #PancreaticCancer cells @faseborg.bsky.social Protein Phosphorylation! @yalepathology.bsky.social @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...biorxiv.orgPhosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibitionDespite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle.... 052
christianfruiz.bsky.social @christianfruiz.bsky.social · 25/06/2025PI3K takes the spotlight when KRAS is inhibited in PDAC. Fantastic preprint from @xiangyuge.bsky.social now up! 020
christianfruiz.bsky.social @christianfruiz.bsky.social · 07/04/2025🔁 Check out our new preprint exploring how dietary fats influence pancreatic cancer progression through ferroptosis sensitivity! 🦠🔥 In our model, MUFAs promote tumorigenesis, while PUFAs show protective effects. Read more here 📄👇 #CancerResearch #Ferroptosis #LipidMetabolism #bioRxiv” 000
