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Stefan Oberlin

@chnebster.bsky.social

Reposted by Stefan Oberlin

Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · 06/08/2026

New paper! A team led by @dbuendia.bsky.social and group leader Arturo Marí-Ordóñez at the GMI of the @oeaw.bsky.social investigated how plants silence potentially parasitic transposons when these “jumping genes” take over most of the genome.

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Reposted by Stefan Oberlin

Nature Methods @natmethods.nature.com · 02/06/2026

High multiplicity of infection sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers. www.nature.com/articles/s41...

nature.com

Multiplexed perturbation enables scalable pooled screens - Nature Methods

This paper shows that high MOI sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers, challenging conventional reliance on low-MOI infections.

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Stefan Oberlin @chnebster.bsky.social · 25/05/2026

A project from my postdoc in the McManus lab @mcmanuslab.bsky.social at UCSF @ucsfdc.bsky.social is out today 🎉 For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell. We challenged that assumption. 🤯 www.nature.com/articles/s41592-026-03095-w

nature.com

Multiplexed perturbation enables scalable pooled screens - Nature Methods

This paper shows that high MOI sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers, challenging conventional reliance on low-MOI infections.

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